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| 1 | 社区糖尿病患者获得社会支持与自我管理行为的相关关系显示文摘目的:探讨中国社区糖尿病患者从家人或朋友获得直接支持和间接支持的现状,以及患者获得的直接支持与间接支持水平与其自我管理行为的相关关系。方法:研究对象的数据来自'北京市通州区社区诊断(2015)'专项调查,对符合要求的474名社区糖尿病患者进行问卷调查、体格检查和糖化血红蛋白(glycated hemoglobin,Hb A1c)测量。应用糖尿病自我管理行为量表(the summary of diabetes self-care activities measure,SDSCA)对自我管理行为进行测量,应用糖尿病直接支持和间接支持量表(directive and nondirective support scale among patients with diabetes,DNSS-PD)对直接支持和间接支持水平进行测量,分析患者获得的直接支持与间接支持水平与其自我管理行为的相关关系。结果:共有452名患者纳入分析,患者获得的直接支持实际情况平均得分为2.53±1.07,27.6%患者获得的直接支持水平较高。患者获得的间接支持实际情况平均得分为3.13±1.12,50.8%患者获得的间接支持水平较高。患者SDSCA平均总得分为35.38±14.21,得分率为45.95%,仅20.6%患者自我管理的总体情况较好。直接支持水平高组患者的SDSCA平均总得分、饮食和运动维度得分、自我管理总体情况、饮食和运动维度自我管理情况显著优于直接支持水平低组。间接支持水平高组患者的SDSCA平均总得分,饮食、运动、血糖监测、足部护理、吸烟维度得分,自我管理总体情况,饮食、运动、血糖监测、足部护理以及吸烟维度自我管理情况均显著优于间接支持水平低组。性别(OR=2.729)、间接支持水平(OR=4.890)、年龄(OR=0.969)和体质指数(body msss index,BMI)(OR=0.819)是自我管理行为的重要影响因素。结论:社区糖尿病患者的自我管理情况不太理想,患者获得的间接支持水平高于直接支持水平,但均有待提升。间接支持和间接支持水平高均与糖尿病患者较好的自我管理行为相关,间接支持水平高与5个维度较好的自我管理行为均相关,直接支持水平高与较好的饮食和运动维度的自我管理行为相关。应对于社区男性老年肥胖的糖尿病患者的自我管理给予更多的关注和支持,特别是间接支持。 | 张旭熙 吴士艳 王冯彬 玛依努尔·于苏甫 孙凯歌 胡康 张幸 孙昕霙 Edwin B·FISHER | 2017 | 北京大学学报(医学版)2017，49，3： | 21 |
| 2 | 高热致胚胎发育毒性机理的研究——热休克蛋白合成显示文摘按Kimmel实验条件热暴露孕10天大鼠。暴露后2小时取胚胎用^(35)S—蛋氨酸标记,SDS—PAGE蛋白分析,可见70和90KilodaltonKD热休克蛋白合成增加。70KD HSP合成用Westernblot分析又进一步得到证实。离体培养胚胎热暴露后,用同样方法分析蛋白,证实70和90KD HSPs合成增加。结果与Kimmel骨骼畸形和胚胎体节融合发生率相符合。本结果为German提出的环境致畸机理假说提供了依据。 | 芦春林 C A Kimmel G L Kimmel D J Heredia B R Fisher N T Brown | 1993 | 北京医科大学学报1993，25，6： | 4 |
| 3 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 4 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 5 | The postnatal growth of the capsule in the human crystalline lens显示文摘 | Fisher RF Pettet B | 1972 | J Anat1972，112，： | 2 |
| 6 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 7 | Arsenic uptake, cytoxocity and detoxification studied in mammalian cells in culture 显示文摘 | Fisher A B Buchet J P Lauwerys RR | 1985 | Arch Toxicol1985，57，3： | 1 |
| 8 | Water-rock interaction in Tertiary sandstone,San Jeoquin Basin,Californa,USA:Diagenetic control on water composition显示文摘 | Fisher J B Boles J R | 1990 | Chemical Geology1990，82，： | 1 |
| 9 | Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer显示文摘 | Anderson S Redmond CK | 1995 | N Engl J Med1995，333，： | 1 |
| 10 | Tamoxifen in treatment of intraductal breast cancer: national surgical adjuvant breast and bowel project B-24 randomised controlled trial显示文摘 | Dignam J Wolmark N | 1999 | Lancet1999，353，9169： | 1 |
| 11 | Applying knowledge to reverse engineering problems显示文摘 | ROBERT B Fisher | 2004 | Computer-Aided Design2004，36，6： | 1 |
| 12 | Effect of preoperative chemotherapy on the outcome of women with operable breastcancer显示文摘 | Fisher B Bryant J Wolmark N | 1998 | J Clin Oncol1998，16，8： | 1 |
| 13 | Ten year results of a randomized clinical trial comparing radical mastectomy and total mastectomy with and without radiation 显示文摘 | Fisher B Redmond C Fish ER | 1985 | N Engl J Med1985，312，11： | 1 |
| 14 | Preoperative chemotherapy:a model for studying the biology and therapy of primary breast cancer显示文摘 | Fisher B Mamounas EP | 1995 | J Clin Oncol1995，13，3： | 1 |
| 15 | Conserved gene sequences for species identification: PCR analysis of the 3'UTR of the SON gene distinguishes human and other mammalian DNAs 显示文摘 | Soteriou B Fisher RA Khan IM | 1995 | Forensic Sci Int1995，73，： | 1 |
| 16 | Singlemode optical swithes based on SOI waveguide with large cross-section显示文摘 | FISHER U ZINKE T SCHUPPERT B | 1994 | Electronics Letters1994，30，5： | 1 |
| 17 | Association of tamoxifen and uterine sarcoma显示文摘 | Wickerham DL Fisher B Wolmark N | 2002 | Clin Oncol2002，20，11： | 1 |
| 18 | Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer显示文摘 | Fisher B Anderson S Bryant J | 2002 | N Engl J Med2002，347，16： | 1 |
| 19 | Distribution and occurrence of aliphatic acid ani- ons in deep subsurface waters显示文摘 | Fisher J B | 1987 | Geochimica et Cosmoehimica Acta1987，51，24： | 1 |
| 20 | Treatment of axillary lymph node - negative, estrogen receptor - negative breast cancer: updated findings from National Surgical Adjuvant Breast and Bowel Project clinical trials显示文摘 | Fisher B Jeong JH Anderson S | 2004 | J Natl Cancer Inst2004，96，24： | 1 |
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