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| 1 | 直肠癌直肠系膜切除术联合或者不联合侧方淋巴结清扫的随机试验长期随访(JCOG 0212)显示文摘背景:日本临床肿瘤学组(Japanese Clinical Oncology Group,JCOG)0212(ClinicalTrials.gov NCT00190541)试验是一个关于无侧方淋巴结肿大的Ⅱ~Ⅲ期直肠癌的Ⅲ期非劣效性临床试验。该试验比较了单纯直肠系膜切除术(mesorec⁃tal excision,ME)和ME联合侧方淋巴结清扫术(lateral lymph node dissection,LLND)的效果,其主要终点是无复发生存率(RFS),5年初步结果分析未能证实单纯ME非劣效于ME联合LLND。本研究的目的是通过JCOG 0212的长期随访数据来分析单纯ME是否非劣效于ME联合LLND。 | 梁逸超 TSUKAMOTO S FUJITA S OTA M | 2020 | 结直肠肛门外科2020，26，3： | 9 |
| 2 | 小胶质细胞可能通过选择性吞噬丘脑底核谷氨酸能突触来代偿多巴胺能神经元丢失造成的帕金森模型鼠的功能缺失显示文摘当帕金森患者出现临床症状时,其黑质致密部的绝大部分多巴胺神经元已发生退行性改变。这提示可能存在某些代偿机制,延缓了临床症状的出现。本研究制作6-羟多巴胺诱导的偏侧帕金森大鼠模型,观察位于黑质下网状部和苍白球的激活的小胶质细胞在代偿机制中的作用。研究发现,在偏侧帕金森大鼠中,黑质下网状部聚集的激活的小胶质细胞远多于苍白球中。激活的小胶质细胞胞体增大并表达吞噬物标志物CD68和NG2蛋白多糖。激活的小胶质细胞聚集在黑质下网状部的特定部位,该部位的突触蛋白I和突触后密集蛋白95的表达降低。活化的小胶质细胞吞噬突触前、后膜上的各种蛋白,包括NMDA受体。将红色荧光标记物Di I作为顺行示踪剂注入丘脑底核,可见黑质下网状部和苍白球内的细胞吞噬了Di I。在谷氨酸刺激下,原代培养的小胶质细胞吞噬活动增强,编码吞噬相关因子的m RNA转录水平也增加。人工合成的糖皮质激素地塞米松可以减弱这种改变。给PD大鼠皮下注射地塞米松,可以抑制黑质下网状部小胶质细胞的活化,运动功能障碍进一步加重,谷氨酸能突触转录m RNA增加,GABA能突触转录m RNA水平未增加。这些发现提示,当谷氨酸能神经元活动增强时,黑质下网状部和苍白球的小胶质细胞活化,选择性吞噬丘脑底核的谷氨酸能突触。因此,在基底核区可能存在一个负反馈环路,间接地代偿了由于多巴胺能神经元丢失而导致的功能障碍。小胶质细胞在这个负反馈环路中扮演了重要的角色。 | Aono H Choudhury ME Higaki H Miyanishi K Kigami Y Fujita K Akiyama JI Takahashi H Yano H Kubo M Nishikawa N Nomoto M Tanaka J 唐颖馨 | 2017 | 神经损伤与功能重建2017，12，5： | 7 |
| 3 | Imaging pitfalls of pancreatic serous cystic neoplasm and its potential mimickers显示文摘The aim of this article is to clarify diagnostic pitfalls of pancreatic serous cystic neoplasm(SCN) that may result in erroneous characterization. Usual and unusual imaging findings of SCN as well as potential SCN mimickers are presented. The diagnostic key of SCN is to look for a cluster of microcysts(honeycomb pattern), which may not be always found in the center. Fibrosis in SCN may be mistaken for a mural nodule of intraductal papillary mucinous neoplasm(IPMN). The absence of cyst wall enhancement may be helpful to distinguish SCN from mucinous cystic neoplasm. However, oligocystic SCN and branch duct type IPMN may morphologically overlap. In addition, solid serous adenoma, an extremely rare variant of SCN, is difficult to distinguish from neuroendocrine tumor. | Kousei Ishigami Akihiro Nishie Yoshiki Asayama Yasuhiro Ushijima Yukihisa Takayama Nobuhiro Fujita Shunichi Takahata Takao Ohtsuka Tetsuhide Ito Hisato Igarashi Shuji Ikari Catherine M Metz Hiroshi Honda | 2014 | World Journal of Radiology2014，6，3： | 6 |
| 4 | Room temperature continuous wave lasing characteristics of GaLnAsP/lnP microdisk injection laser显示文摘 | Fujita M lnoshita K Baba T | | Electronics Letters0，，： | 2 |
| 5 | Application of the Distributed Database (Data-Free-Way) ou the Analysis of Mechanical Properties in Neutron lrradiated 316 Stainless Steel 显示文摘 | Fujita M Kinugawa J Tsuji H | 2000 | Fusion Engineering and Design2000，，5152： | 2 |
| 6 | Myocardial ischemia enhances the expression of acidic fibroblast growth factor in human pericardial fluid显示文摘 | Iwakura A Fujita M Ikemoto M | 2000 | Heart Vessels2000，15，： | 2 |
| 7 | Diabetes enhances lectin-like oxidized LDL receptor-1(LOX-1)expression in the vascular endothelium:possible role of LOX-1 ligand and AGE显示文摘 | Chen M Nagase M Fujita T | 2001 | Biochem Biophys Res Commun2001，287，4： | 2 |
| 8 | Impact of formal training in endoscopic submucosal dissection for early gastrointestinal cancer: A systematic review and a meta-analysis显示文摘AIM: To summarize the clinical impact of a formal training for the effectiveness and safety of endoscopic submucosal dissection for gastrointestinal cancer.METHODS: We searched databases including PubM ed, EMBASE and the Cochrane Library and Science citation Index updated to August 2014 to include eligible articles. In the Meta-analysis, the main outcome measurements were en bloc resection rate, local recurrence rate(R0) and the incidence of procedure-related complications(perforation, bleeding). RESULTS: En bloc resection was high for both, dissecting stomach tumors with an overall percentage of 93.2%(95%CI: 90.5-95.8) and dissecting colorectal tumors with an overall percentage of 89.4%(95%CI: 85.1-93.7). Although the number of studies reporting R0 resection(the dissected specimen was revealed free of tumor in both vertical and lateral margins) was small, the overall estimates for R0 resection were 81.4%(95%CI: 72-90.8) for stomach and 85.9%(95%CI: 77.5-95.5) for colorectal tumors, respectively. The analysis showed that the percentage of immediate perforation and bleeding were very low; 4.96(95%CI: 3.6-6.3) and 1.4%(95%CI: 0.8-1.9) for colorectal tumors and 3.1%(95%CI: 2.0-4.1) and 4.8%(95%CI: 2.8-6.7) for stomach tumors, respectively. CONCLUSION: In order to obtain the same rate of success of the analyzed studies it is a necessity to create training centers in the western countries during the 'several years' of gastroenterology residence first only to teach EGC diagnose and second only to train endoscopic submucosal dissection. | Miguel A Tanimoto M Lourdes Guerrero Yoshinori Morita Jonathan Aguirre-Valadez Elisa Gomez Carlos Moctezuma-Velazquez Jose A Estradas-Trujillo Miguel A Valdovinos Luis F Uscanga Rikiya Fujita | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，4： | 2 |
| 9 | Use of nerve blocks for botulinum toxin treatment of palmar-plantar hyperhidrosis显示文摘 | Fujita M Mann T Mann O | 2001 | J Am Acad Dermatol2001，45，： | 2 |
| 10 | Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells 显示文摘 | Fujita N Kajita M Taysavang P | 2004 | Mol Endocrinol2004，38，12： | 1 |
| 11 | Experiment and validation of numerical simulation of coupled thermal, hydraulic and mechanical behaviour in the engineered buffer materials 显示文摘 | Chijimatsu M Masakazu A Fujita C | 2000 | International Journal for Numerical and Analytical Methods in Geomechanics2000，24，4： | 1 |
| 12 | Cloning and nuclcotide sequence of the gene (amyP) for maltotetraose-forming amylase from Pseudomonas stutzeri MO-191显示文摘 | Fujita M Torigoe K Nakada T | 1989 | Journal of Bacteriology1989，171，3： | 1 |
| 13 | Purification,characterization,and cDNA structure of isoamylase from developing endosperm of rice显示文摘 | Kubo A Francisco P B Jr Nakakita M Harada K Minaka N Nakamura Y | 1999 | Planta1999，208，2： | 1 |
| 14 | Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure 显示文摘 | Tsukamoto O Fujita M Kato M | 2009 | J Am Coll Cardiol2009，53，： | 1 |
| 15 | The new economic geography: Past, present and the future显示文摘 | Fujita M Krugman P | 2004 | Papers in Regional Science2004，，83： | 1 |
| 16 | Neogenin regulates neuronal survival through DAP kinase显示文摘 | Fujita Y Taniguchi J Uchikawa M | 2008 | Cell Death Differ2008，15，10： | 1 |
| 17 | Regiochemical control of monolignol radical coupling : a now paradigm for lignin and lignan biosynthesis显示文摘 | Gang D R Costa M A Fujita M | 1999 | Chem Biol1999，6，3： | 1 |
| 18 | Structural mechanism of RNA recognition by the RIG-I-like receptors 显示文摘 | YONEYAMA M FUJITA T | 2008 | Immunity2008，29，2： | 1 |
| 19 | Molecular hydrogen suppres- ses FcepsilonRI-mediated signal transduction and prevents degran- ulation of mast ceils 显示文摘 | ITOH T FUJITA Y ITO M | 2009 | Biochem Biophys Res Commun2009，389，4： | 1 |
| 20 | T Cellular basis for the automorphic curvature of rice coleoptiles on a three-dimensional clinostat: possible involvement of reorientation of cortical microtubules 显示文摘 | Saiki M Fujita H Soga K | 2005 | J Plant Res2005，118，： | 1 |
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