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| 1 | Effect of thrombectomy on oedema progression and clinical outcome in patients with a poor collateral profile显示文摘Background and purpose The impact of the cerebral collateral circulation on lesion progression and clinical outcome in ischaemic stroke is well established.Moreover,collateral status modifies the effect of endovascular treatment and was therefore used to select patients for therapy in prior trials.The purpose of this study was to quantify the effect of vessel recanalisation on lesion pathophysiology and clinical outcome in patients with a poor collateral profile.Materials and methods 129 patients who had an ischaemic stroke with large vessel occlusion in the anterior circulation and a collateral score(CS)of 0-2 were included.Collateral profile was defined using an established 5-point scoring system in CT angiography.Lesion progression was determined using quantitative lesion water uptake measurements on admission and follow-up CT(FCT),and clinical outcome was assessed using modified Rankin Scale(mRS)scores after 90 days.Results Oedema formation in FCT was significantly lower in patients with vessel recanalisation compared with patients with persistent vessel occlusion(mean 19.5%,95%CI:17%to 22%vs mean 27%,95%CI:25%to 29%;p<0.0001).In a multivariable linear regression analysis,vessel recanalisation was significantly associated with oedema formation in FCT(ß=−7.31,SD=0.015,p<0.0001),adjusted for CS,age and Alberta Stroke Program Early CT Score(ASPECTS).Functional outcome was significantly better in patients following successful recanalisation(mRS at day 90:4.5,IQR:2-6 vs 5,IQR:5-6,p<0.001).Conclusion Although poor collaterals are known to be associated with poor outcome,endovascular recanalisation was still associated with significant oedema reduction and comparably better outcome in this patient group.Patients with poor collaterals should not generally be excluded from thrombectomy. | Gabriel Broocks Andre Kemmling Tobias Faizy Rosalie McDonough Noel Van Horn Matthias Bechstein Lukas Meyer Gerhard Schon Jawed Nawabi Jens Fiehler Helge Kniep Uta Hanning | 2021 | Stroke & Vascular Neurology2021，6，2： | 2 |
| 2 | GC/GCMS analysis of the petroleum ether and dichloromethane extracts of Moringa oleifera roots显示文摘Objective:To explore the phytochemical constituents from petroleum ether and diehloromethane extracts of Moringa oleifera(M.oleufera)roots using GC/GC—MS.Methods:A total of 5.11 kg fresh and undried crashed root of M.oleifera were cut into small pieces and extracted with petroleum ether and diehloromethane(20 L.each) at room temperature for 2 d.The concentrated extracts were subjected to their GC—MS analysis.Results:The GC-MS analysis of the petroleum ether and diehloromethane extracts of M.oleifern roots,which showed promising biological activities,has resulted in the identification 102 compounds.These constituents belong to 15 classes of compounds including hydrocarbons,fatty acids,esters,alcohols,isolhioeyanate.thiocyanale,pyrazine,aromalics.alkamides.cyanides,steroids,halocompounds.urea and N-hydroxyimine derivatives,unsaturated alkenamides.alkyne and indole.GC/GC-MS studies on petroleum ether extraet of the roots revealed that it contained 39 compounds,belonging to nine classes.Cyclooctasulfur S8 has been isolated as a pure compound from the extract.The major compounds identified from petroleum ether extract were trans-13-clocosene(37.9%).nonacosane(32.6%).cycloartenol(28.6%) nonadecanoic acid(13.9%) and cyclooctasulfur S8(13.9%).Dichloromethane extract of the roots was composed of 63 compounds of which nasimizinol(58.8%) along with oleic acid(46.5%),N—benzyl-N-(7—cyanato heptanamide(38.3%),N—benzyl-N—(1—chlorononyl) amide(30.3%),bis[3—benzyl prop-2-ene]-1-one(19.5%) and N.N-dibeuzyl—2-ene pent 1.5—diamide(11.6%) were the main constituents.Conclusions:This study helps to predict the formula and structure of active molecules which can be used as drugs.This result also enhances the traditional usage of M.oleifera which possesses a number of bioactive compounds. | Shaheen Faizi saima sumbul Muhammed Ali Versiani Rubeena Saleem Aisha Sana Hira Siddiqui | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，8： | 2 |
| 3 | Tetracyclic triterpe- noids and their derivatives from Azadirachta indica 显示文摘 | Siddiqui S Siddiqui B S Faizi S | 1988 | Journal of Natural Products1988，51，1： | 1 |
| 4 | Design an opti- mum pattern of orientation in residential complexes by analyzing the level of energy consumption 显示文摘 | FAIZI F NOORANI M GHAEDI A | 2011 | Proce- dia Engineering2011，，21： | 1 |
| 5 | Is body temperature an independent predictor of mortality in hip fracture patients Injury 显示文摘 | Faizi M Farrier AJ Venkatesan M | 2014 | 24(12) : 1942-19452014，24，12： | 1 |
| 6 | Errors in prepara- tion and administration of intravenous medications in the intensive care unit of a teaching hospital: an observation- al study显示文摘 | Fahimi F Ariapanah P Faizi M | 2008 | Aust Crit Care2008，21，2： | 1 |
| 7 | Physical stability and aerosol properties of liposomes delivered using an air-jet nebulizer and a novel micropump device with large mesh apertures显示文摘 | ELHISSI A M FAIZI M NAJI W F | 2007 | Int J Pharm2007，334，12： | 1 |
| 8 | Physical stability and aerosol properties of liposomes delivered using an air-jet nebulizer and a novel micropump device with large mesh apertures显示文摘 | Elhissi AM Faizi M Naji WF | 2007 | Int J Pharm2007，334，12： | 1 |
| 9 | Glutathione peroxidase activity in obese and nonobese diabetic patients and role of hyperglycemia in oxidative stress 显示文摘 | Goyal R Singhai M Faizy A F | 2011 | Midlife Health2011，2，2： | 1 |
| 10 | Synthesis and anticonvulsant activity of new 2-substituted-5--1,3,4-oxadiazoles and 1,2,4-triazoles显示文摘 | ALMASIRAD A TABATABAI S A FAIZI M | 2004 | Bioorganic & Medicinal Chemistry Letters2004，14，24： | 1 |
| 11 | Errors in prepa ration and administration of intravenous medications in the intensive care unit of a teaching hospital:an observational study显示文摘 | Fahimi F Ariapanah P Faizi M | 2008 | Aust Crit Care2008，21，2： | 1 |
| 12 | Magnetic resonance imaging and positron emission tomography - computed tomography evaluation of soft tissue sarcoma with surgical and histopathological correlation 显示文摘 | Faizi NA Thulkar S Sharma R | 2012 | Indian J Nucl Med2012，27，4： | 1 |
| 13 | Hypotensive effect of chemi-cal constituents from aloe barbadensis显示文摘 | Saleem R Faizi S Siddiqui BS | 2001 | Planta Med2001，67，： | 1 |
| 14 | Glutathione peroxidase activity in obese and nonobese diabetic patients and role of hyperglycemia in oxi?dative stress显示文摘 | GOYAL R SINGHAI M FAIZY A F | 2011 | J Midlife Health2011，2，2： | 1 |
| 15 | Effect of different supports and promoters upon the structure and morphology of precursors and catalysts显示文摘 | MIRZAEI A A HABIBPOUR R FAIZI M KASHI E | 2006 | Appl Catal A:Gen2006，301，2： | 1 |
| 16 | Synthesis and Anticonvulsant Activity of New 2-Substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles显示文摘 | ZARGHI A TABATABAI S A FAIZI M | 2005 | Bioorg Med Chem2005，15，17： | 1 |
| 17 | Gender differences in age at on set of schizophrenia显示文摘 | Naqvi H Khan MM Faizi A | 2005 | Coll Physicians Surg Pak2005，，15： | 1 |
| 18 | Tetracyclic triterpenoids and their derivatives from Azadirachta indica显示文摘 | Siddiqui S Siddiqui BS Faizi S | 1988 | J Nat Prod1988，51，： | 1 |
| 19 | Analgesic and antioxidant activity of mangiferin and its derivatives: the structure activity relationship显示文摘 | Dar A Faizi S Naqvi S | 2005 | Biol Pharm Bull2005，28，4： | 1 |
| 20 | Hypotensive constituents from the pods of Moringa oleifera显示文摘 | Faizi S siddiqui B.S Saleem R | | 0，，： | 1 |
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