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| 1 | High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test显示文摘AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods. | Márcia Soares-Mota Tianny A Silva Luanda M Gomes Marco AS Pinto Laura MC Mendon?a Maria Lúcia F Farias Tiago Nunes Andrea Ramalho Cyrla Zaltman | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Moringa oleif-era:bioactive compounds and nutritional potential显示文摘 | FERREIRA P M P FARIAS D F OLIVEIRA J T A | 2008 | Brazilian Journal ofNutrition2008，21，4： | 1 |
| 4 | Adsorp tion of anionic and Cationic dyes on activated carbons with different surface chemistries显示文摘 | Faria P C C (O)rafo J J M PereiraM F R | 2004 | Water Res2004，38，： | 1 |
| 5 | Prevalence of anti Toxoplasma gondii and anti-Neospora caninum antibodies in goats slaughtered in the public slaughterhouse of Paros city, Paraliba State, Northeast region of Brazil显示文摘 | Faria E B Gennari S M Pena H F J | 2007 | Veterinary Parasitology2007，149，： | 1 |
| 6 | Commercial quality of pot chrysanthemum,cultivar Puritan,irrigated at different substrate water tension in a greenhouse显示文摘 | De Farias M F Saad J C C Boas R L V | 2003 | Irrigation2003，8，2： | 1 |
| 7 | Oxygen evolution at RuOz (x) + Co3 04 ( 1 - x) electrodes from acid solution 显示文摘 | Da Silva L M Boodts J F C De Faria L A | 2001 | Electrochimica Acta2001，46，9： | 1 |
| 8 | Adsorption of anionic and cationic dyes on activated carbon with different surface chemistries显示文摘 | Faria P C 6 rfno J JM Pereira M F R | 2004 | Water Reasearch2004，38，8： | 1 |
| 9 | Irrigation schedule in pot chrysanthemum,cultivar Rage,grown in greenhouse显示文摘 | De Farias M F Saad J C C Boas R L V | 2004 | Engenharia-Agricola2004，24，1： | 1 |
| 10 | Structure and correlations in two-dimensional classical artificial atoms confined by a Coulomb potential显示文摘 | Ferreira W P Matulis A Farias G A Peeters F M | 2003 | Phys Rev E2003，67，04： | 1 |
| 11 | Ozonation of aniline protnoted by activated carbon显示文摘 | Faria P C Orfao J J Pereira M F | 2007 | Chemosphere2007，67，4： | 1 |
| 12 | Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2by isatin:a molecular mechanism of protection against TNBS-induced colitis in rats显示文摘 | Socca E A Luiz-Ferreira A Faria F M | 2014 | Chem Biol Interact2014，209，1： | 1 |
| 13 | Growth and quality of chrysanthemum produced in greenhouse显示文摘 | Farias M F Saad J C C | 2005 | Horticultura-Brasileira2005，23，3： | 1 |
| 14 | Normal mode spectra of two-dimensional classical atoms confined by a Coulomb potential显示文摘 | Ferreira W P Peeters F M Farias G A | 2003 | Phys Rev E2003，68，06： | 1 |
| 15 | Enantiodivergent syntheses of cycloheptenone intermediates for guaiane sesquiterpenes 显示文摘 | FARIA M L MAGALHAES R A SILVA F C | 2000 | Tetrahedron : Asymmetry2000，11，20： | 1 |
| 16 | Structural phase transitions and unusual melting behavior in a classical twodimensional Coulomb bound cluster显示文摘 | Ferreira W P Partoens B Peeters F M Farias G A | 2005 | Phys Rev E2005，71，02： | 1 |
| 17 | Role of dehydration catalyst acid properties on one-step DME synthesis over physical mixtures显示文摘 | Ramos F S De Farias A M D Borges L E P | 2005 | Catal Today2005，101，1： | 1 |
| 18 | Desempenho, qualidade dos ovos e balanqo de nitrogEnio de poedeiras comerciais alimentadas corn raq6es contendo diferentes niveis de protefna bruta e lisina 显示文摘 | RIZZO SILVA M F EMYGDIO DE FARIA D WICK RIZZOLI P | 2010 | Revista Brasileira deZootecnia2010，39，6： | 1 |
| 19 | Mineralisation of colored aqueous solutions by ozonation in the presence of activated carbon 显示文摘 | Faria P C C Orfao J J M Pereira M F R | 2005 | Water Res2005，39，8： | 1 |
| 20 | Influence of oxygen availability on cell growth and xylitol production by Candida guilliermondii显示文摘 | Faria L F F Gimenes M A P Nobrega R | 2002 | Appl Biochem Biotechnol2002，98，10： | 1 |
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