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| 1 | Systematic review of ablative therapy for the treatment of renal allograft neoplasms显示文摘BACKGROUND To date,there are no guidelines on the treatment of solid neoplasms in the transplanted kidney.Historically,allograft nephrectomy has been considered the only reasonable option.More recently,nephron-sparing surgery (NSS) and ablative therapy (AT) have been proposed as alternative procedures in selected cases.AIM To review outcomes of AT for the treatment of renal allograft tumours.METHODS We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009 Checklist.PubMed was searched in March 2019 without time restrictions for all papers reporting on radiofrequency ablation (RFA),cryoablation (CA),microwave ablation (MWA),high-intensity focused ultrasound (HIFU),and irreversible electroporation (IRE) of solid tumours of the kidney allograft.Only original manuscripts describing actual cases and edited in English were considered.All relevant articles were accessed in full text.Additional searches included all pertinent references.Selected studies were also assessed for methodological quality using a tool based on a modification of the Newcastle Ottawa scale.Data on recipient characteristics,transplant characteristics,disease characteristics,treatment protocols,and treatment outcomes were extracted and analysed.Given the nature and the quality of the studies available (mostly retrospective case reports and small retrospective uncontrolled case series),a descriptive summary was provided.RESULTS Twenty-eight relevant studies were selected describing a total of 100 AT procedures in 92 patients.Recipient age at diagnosis ranged from 21 to 71 years whereas time from transplant to diagnosis ranged from 0.1 to 312 mo.Most of the neoplasms were asymptomatic and diagnosed incidentally during imaging carried out for screening purposes or for other clinical reasons.Preferred diagnostic modality was Doppler-ultrasound scan followed by computed tomography scan,and magnetic resonance imaging.Main tumour types were: papillary renal cell carcinoma (RCC) and clear cell RCC.Maximal tumour diameter ranged from 5 to 55 mm.The vast majority of neoplasms were T1a N0 M0 with only 2 lesions staged T1b N0 M0.Neoplasms were managed by RFA (n = 78),CA (n = 15),MWA (n = 3),HIFU (n = 3),and IRE (n = 1).Overall,3 episodes of primary treatment failure were reported.A single case of recurrence was identified.Follow-up ranged from 1 to 81 mo.No cancer-related deaths were observed.Complication rate was extremely low (mostly < 10%).Graft function remained stable in the majority of recipients.Due to the limited sample size,no clear benefit of a single procedure over the other ones could be demonstrated.CONCLUSION AT for renal allograft neoplasms represents a promising alternative to radical nephrectomy and NSS in carefully selected patients.Properly designed clinical trials are needed to validate this therapeutic approach. | Evaldo Favi Nicholas Raison Federico Ambrogi Serena Delbue Maria Chiara Clementi Luca Lamperti Marta Perego Matteo Bischeri Mariano Ferraresso | 2019 | World Journal of Clinical Cases2019，7，17： | 2 |
| 2 | Factors influencing structure formation and phase size in an immiscible polymer blend of polycarbonate and polypropylene prepared by twin-screw ex- trusion 显示文摘 | FAVIS B D THERRIEN D | 1991 | Polymer1991，32，8： | 1 |
| 3 | The role of interfacial contact in immiscible binary polymer blends and its influence on mechanical properties显示文摘 | Leclair A Favis B D | 1996 | Polymer1996，37，： | 1 |
| 4 | Phase Size/Composition Dependence in Irmni~ible Blends: Experimental and Theoretical Considerations显示文摘 | Favis B D Willis J M | 1990 | J Pol~n Sci Part B: Polym Phys1990，28，： | 1 |
| 5 | Factors influencing structure formation and phase size in an immiscible polymer blend of polycarbonate and polypropylene prepared by twin-screw extrusion显示文摘 | Favis B D Therrien D | 1991 | Polymer1991，32，： | 1 |
| 6 | Factors influencing encapsulation behavior in composite droplet-type polymer blends 显示文摘 | REIGNIER J FAVIS B HEUZEY M | 2003 | Polymer2003，44，1： | 1 |
| 7 | Droplet/Fiber Transitions in Immiscible Polymer Blends Generated During Melt Processing显示文摘 | Chapleau N Favis B D | 1995 | J Mater Sci1995，30，： | 1 |
| 8 | Brittle-though Transition in Nylon/ Rubber Blends: Effect of Interparticle Distance 显示文摘 | Favis B D Chalifoux | 1999 | Polymer1999，29，： | 1 |
| 9 | Universal DNA array detection of small insertions and deletions in BRCA1 and BRCA2显示文摘 | Favis R Day J P Gerry N P Phelan C Narod S Barany F | 2000 | Nature Biotechnology2000，18，： | 1 |
| 10 | A self-organising dynamic systems approach to the the simulation of rill initiation and development on hillslopes显示文摘 | FAVIS MORTKMK D T | 1998 | Computers and Geosciences1998，24，4： | 1 |
| 11 | Control of the subinclusion micro- structure in HDPE/PS/PMMA ternary blends 显示文摘 | REIGNIER J FAVIS B | 2000 | Macro- molecules2000，33，19： | 1 |
| 12 | 显示文摘 | Favis B D | 1994 | Polymer1994，35，7： | 1 |
| 13 | Coarsening of immiscible co-continuous blends during quiescent annealing显示文摘 | YUAN Zhen-hua BASIL D FAVIS | 2005 | AICHE2005，51，1： | 1 |
| 14 | High performance polyethylene/thermoplastic starch blends through controlled emulsification phenomena 显示文摘 | CERCLE C SARAZIN P FAVIS B D | 2013 | Carbohydr Polym2013，92，： | 1 |
| 15 | The implications of general circulation modelestimates of rainfall for future erosion: a case study from Brazil 显示文摘 | Favis - Mortlock D T and A J T Guerra | 1999 | Catena1999，37，： | 1 |
| 16 | Coarsening of immiscible co-continuous blends during quiescent annealing 显示文摘 | YUAN Z FAVIS B D | 2005 | AICHE Journal2005，51，1： | 1 |
| 17 | Factors influencing structure formation and phase size in an immiscible polymer blend of polycarbonate and polypropylene prepared by twin-screw extrusion 显示文摘 | Favis B D Therrient D | 1991 | Polymer1991，32，8： | 1 |
| 18 | The relative role of coalescence and interfacial tension in controlling dispersed phase size reduction during the compatibilization of polyethylene terephthalate/polypropylene blends 显示文摘 | Jean Christophe Lepers Basil D Favis Ronald J Tabar | 1997 | Journal of Polymer Science Part B: Polymer Physics1997，35，4： | 1 |
| 19 | Droplet/fibre transitions in immiscible polymer blends generated during melt processing显示文摘 | Chaplean N Favis B D | 1995 | Journal of Materials Science[J]1995，30，1： | 1 |
| 20 | The role of the blend interface type on morphology in co-continuous polymer blends显示文摘 | LI Jian-ming MA Pei-lian BASIL D FAVIS | 2002 | Macromolecules2002，35，： | 1 |
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