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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea 显示文摘 | Melo M R S Feitosa J P A Freitas A L P | 2002 | Carbohydr Poly2002，49，： | 1 |
| 3 | Inheritance of the waist-to-hip ratio in the national heart, lung, and blood institute family heart study 显示文摘 | FEITOSA M F BORECKI I STEVEN C | 2000 | Obesity Research2000，8，： | 1 |
| 4 | Development of metal oxide nanoparticles by soft chemical method显示文摘 | Bernardi M I B Feitosa C A C Paskocimas C A | 2009 | Ceramics International2009，35，： | 1 |
| 5 | Chemical composition and larvicidal activity of Rollinia leptopetala (Annonaceae) 显示文摘 | Feitosa E M A Arriaga A M C Santiago G M P | 2009 | J BrazChemSoc2009，20，2： | 1 |
| 6 | Vesicle micelle transition in mixtures of mide with muir, 2006 chloride and bro- nonionic and zwitterionic surfaetants 显示文摘 | Feitosa E Bonassi N M Loh W | 2006 | Lang-2006，22，10： | 1 |
| 7 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea显示文摘 | MELO M R S FEITOSA J P A FREITAS A L P | 2002 | Carbohyd Polym2002，49，： | 1 |
| 8 | Effect of the surgical technique on long-term outcome of pancreas transplantation显示文摘 | Feitosa Dawhara M Benchaib M | 1998 | Transpl Int1998，11，4： | 1 |
| 9 | Isolation and characterization of soluble sulfated polysaccharide from the redseaweed Gracilada cornea显示文摘 | Melo M R S Feitosa J P A Freitas A L P | 2002 | Carbohydrate Polymers2002，49，4： | 1 |
| 10 | Development of metal oxide nanoparticles by soft chemical method 显示文摘 | BERNARDI M I B FEITOSA C A C PASKOCIMAS C A | 2009 | Ceramics International2009，35，1： | 1 |
| 11 | Behavior problems and prevalence of asthma symptoms among Brazilian chil- dren显示文摘 | Feitosa C A Santos D N Barreto do Carmo M B | 2011 | J Psychosom Res2011，71，3： | 1 |
| 12 | Liquid- liquid equilibrium for ternary mixtures of biodiesel (soybean or sunflower) + glycerol + ethanol at different temperatures 显示文摘 | Mesquita F M R Feitosa F X Sombra N E | 2011 | Journal of Chemical & Engineering Data2011，56，11： | 1 |
| 13 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea显示文摘 | Melo M R S Feitosa J P A Freitas A L P | 2002 | Carbohydrate Polymers2002，49，4： | 1 |
| 14 | Sequence variation of the alpha-lactalbumin gene in Holstein and Nellore cows显示文摘 | Martins L F Milazzotto M P Feitosa W B | | 0，，03： | 1 |
| 15 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Graccilaria cornea显示文摘 | M R S Melo J P A Feitosa A L P Freitas | 2002 | Carbohydrate Polymers2002，，49： | 1 |
| 16 | Carboxymethyla tion of cashew tree exudate polysaccharide显示文摘 | Silva D A Paula C M Feitosa P A etal | 2004 | Carbohydrate Polymers2004，58，2： | 1 |
| 17 | Effect of t he surgical technique on long-term outcome of pancreas transplantation显示文摘 | Feitosa Tajra L C Dawhara M Benchaib M | 1998 | Tra nspl Int1998，11，： | 1 |
| 18 | Salt-induced sphere-to-disk transition of octadecyhrimethylammonium bromide micelles 显示文摘 | Swanson-Vethamuthu M Feitosa E Brown W | 1998 | Langmuir1998，14，： | 1 |
| 19 | Coutinho A R, Goissis M D, Oliveira V P, Assumpcao M E, Visintin J A, Effect of chemical or electrical activation of bovine oocytes on blastocyst development and quality显示文摘 | Milazzotto M P Feitosa W B | 2008 | Reprod Domest Anita2008，43，： | 1 |
| 20 | Simultaneous pancreas-kidney transplantation: portal versus systemic venous drainage of the pancreas allografts 显示文摘 | Petruzzo P Da Silva M Feitosa LC | 2000 | Clin Transplant2000，14，41： | 1 |
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