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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Extracting typical occupancy schedules from social media (TOSSM) and its integration with building energy modeling显示文摘Building occupancy,one of the most important consequences of occupant behaviors,is a driving influencer for building energy consumption and has been receiving increasing attention in the building energy modeling community.With the vast development of information technologies in the era of the internet-of-things,occupant sensing and data acquisition are not limited to a single node or traditional approaches.The prevalence of social networks provides a myriad of publically available social media data that might contain occupancy information in the space for a given time.In this paper,we explore two approaches to extract the typical occupancy schedules for the input to the building energy simulation based on the data from social networks.The first approach uses text classification algorithms to identify whether people are present in the space where they are posting on social media.On top of that,the typical building occupancy schedules are extracted with assumed people counting rules.The second approach utilizes the processed Global Positioning System(GPS)tracking data provided by social networking service companies such as Facebook and Google Maps.Web scraping techniques are used to obtain and post-process the raw data to extract the typical building occupancy schedules.The results show that the extracted building occupancy schedules from different data sources(Twitter,Facebook,and Google Maps)share a similar trend but are slightly distinct from each other and hence may require further validation and corrections.To further demonstrate the application of the extracted Typical Occupancy Schedules from Social Media(TOSSM),data-driven models for predicting hourly energy usage prediction of a university museum are developed with the integration of TOSSM.The results indicate that the incorporation of TOSSM could improve the hourly energy usage prediction accuracy to a small extent regarding the four adopted evaluation metrics for this museum building. | Xing Lu Fan Feng Zhihong Pang Tao Yang Zheng O’Neill | 2021 | Building Simulation2021，14，1： | 3 |
| 3 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 4 | Design of a mega-sub-controlled building system under stochastic wind loads显示文摘 | FENG M O CHAI W | 1997 | ASCE Journal of Engineering Mechanics1997，12，3： | 1 |
| 5 | Production of volatile compounds by Rhizopus oligosporus during soybean and barley tempeh fermentation显示文摘 | FENG X M LARSEN T O SCHNORER J | 2007 | International Journal of Food Microbiology2007，113，2： | 1 |
| 6 | Self-discharge characteristics of a metal hydride electrode for Ni-MH rechargeable batteries 显示文摘 | FENG F NORTHWOOD D O | 2005 | Int J Hydorgen Energ2005，30，： | 1 |
| 7 | Genetic and environmental contributions to platelet aggregation, the Framingham heart study显示文摘 | O'Donnell CJ Larson MG Feng D | 2001 | Circulation2001，103，25： | 1 |
| 8 | Measuring fracture orientation at exposed rock faces by using a non-reflector total station显示文摘 | FENG Q SJ(O)GREN P STEPHANSSON O | 2001 | Engineering Geology2001，59，12： | 1 |
| 9 | A game theoretic algo- rithmto compute local stabilizing solutions to hjbi equations in nonlinear Hc control显示文摘 | Feng Y Anderson B D O Rotkowitz M | 2009 | Automatica2009，45，4： | 1 |
| 10 | Modeling studies of the effect ofthermal and electrical conductivities and relative density of field-activatedself-propagating combustion synthesis 显示文摘 | CARRILLOHEIAN E M GRAEVE O A FENG A | 1999 | J Mater Res1999，14，5： | 1 |
| 11 | Prediction of cutting forces in three and five-axis ball-end milling with tool indentation effect 显示文摘 | Tuysuz O Altintas Y Feng H Y | 2013 | International Journal of Machine Tools and Manufacture2013，66，2： | 1 |
| 12 | Photo-Assisted Fenton Mineralization of an Azo-Dye Acid Black Using a Modified Laponite Clay-Based Fe Nanocomposite as a Heterogeneous Catalyst显示文摘 | Sum O S N Feng J Y Hu X J | 2005 | Topics Catal2005，33，4： | 1 |
| 13 | Improved performance of a metal hydride electrode for nickel/metal hydride batteries through copper-coating显示文摘 | FENG F NORTHWOOD D O | 2003 | Surface and Coatings Technology2003，167，23： | 1 |
| 14 | Synthesis of methane gas hydrate in porous sediments and its dissociation by depressurizing 显示文摘 | Hisashi O Kono Sridhar Narasimhan Feng Songa | 2002 | Powder Technology2002，122，2： | 1 |
| 15 | Prospects for Targeting Protein Kinase C Isozymes in the Therapy of Drug-resistant Cancer – An Evolving Story显示文摘 | Catherine A. O’Brian Nancy E. Ward Jubilee R. Stewart Feng Chu | 2001 | Cancer and Metastasis Reviews2001，，1： | 1 |
| 16 | Self-discharge characteristics of a metal hydride electrode for Ni-MH rechargeable batteries 显示文摘 | Feng F Northwood D O | 2005 | International J Hydrogen Energy2005，30，： | 1 |
| 17 | Configuration analysis of five-axis machine tools using a generic kinematic model显示文摘 | TUTUNEA-FATAN O R FENG H Y | 2004 | International Journal of Machine Tools and Manufacture2004，44，11： | 1 |
| 18 | Surface wrinkling of mucosa induced by volumetric growth:theory,simulation and experiment 显示文摘 | Li B Cao Y P Feng X O Gao H | 2011 | Journal of the Mechanics and Physics of Solids2011，59，： | 1 |
| 19 | Efficient Monito ring of Parametric Context-Free Patterns显示文摘 | Meredith P O J in Dong-yun Chen Feng | 2010 | Automated Soft- ware Engineering2010，17，2： | 1 |
| 20 | Application of a New in situ 3D Laser Scanner to Study the Scale Effect on the Rock Joint Surface Roughness显示文摘 | FARDIN N FENG Q STEPHANSSON O | 2004 | International Journal of Rock Mechanics and Mining Sciences2004，41，2： | 1 |
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