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| 1 | Clinical significance of granuloma in Crohn's disease显示文摘AIM: Granuloma is considered the hallmark of microscopic diagnosis in Crohn's disease (CD), but granulomas can be detected in only 21-60% of CD patients. The aim of this studywas to evaluate the frequency of granulomas by multiple endoscopic biopsies in patients with CD and to examine whether group of patients with or without granuloma exhibit a different clinical course.METHODS: Fifty-six patients with newly diagnosed Cdwere included in the study. Jejunoscopy, enteroclysis and ileo-colonoscopy were performed in all patients. At least two biopsy specimens from each examined gastrointestinal segment were examined microscopically searching granuloma. The clinical course was followed in all patients, and extraintestinal manifestations as well as details of any immunosuppressive therapy and surgical intervention were noted.RESULTS: Granuloma was found in 44.6% of the cases (25 patients). Patients with granuloma had higher activity parameters at the time of the biopsies. Extraintestinal manifestations were observed and surgical interventions were performed more often in the granuloma group. The need of immunosuppressive therapy was significantly more frequent in the patients with granuloma. Granuloma formation is more often seen in younger patients, and mainly in the severe, active penetrating disease. CONCLUSION: The significantly higher frequency of surgical interventions and immunosuppressive therapy suggests that granuloma formation is associated with a more severe disease course during the first years of CD. | Tamás Molnár László Tiszlavicz Csaba Gyulai Ferenc Nagy János Lonovics | 2005 | World Journal of Gastroenterology2005，11，20： | 5 |
| 2 | Efficacy of 6-mercaptopurine treatment after azathioprine hypersensitivity in inflammatory bowel disease显示文摘AIM:To investigate the efficacy of 6-mercaptopurine (6-MP) in cases of azathioprine (AZA) hypersensitivity in patients with inflammatory bowel disease. METHODS: Twenty nine previously confirmed Crohn’s disease (CD) (n = 14) and ulcerative colitis (UC) (n = 15) patients with a known previous (AZA) hypersensitivity reaction were studied prospectively. The 6-MP doses were gradually increased from 0.5 up to 1.0-1.5 mg/kg per day. Clinical activity indicies (CDAI/CAI), laboratory variables and daily doses of oral 5-ASA, corticosteroids, and 6-MP were assessed before and in the first, sixth and twelfth months of treatment. RESULTS: In 9 patients, 6-MP was withdrawn in the first 2 wk due to an early hypersensitivity reaction. Medication was ineffective within 6 mo in 6 CD patients, and myelotoxic reaction was observed in two. Data were evaluated at the end of the sixth month in 12 (8 UC, 4 CD) patients, and after the first year in 9 (6 UC, 3 CD) patients. CDAI decreased transiently at the end of the sixth month, but no significant changes were observed in the CDAI or the CAI values at the end of the year. Leukocyte counts (P = 0.01), CRP (P = 0.02), and serum iron (P = 0.05) values indicated decreased inflammatory reactions, especially in the UC patients at the end of the year, making the possibility to taper oral steroid doses. CONCLUSION: About one-third of the previously AZA- intolerant patients showed adverse effects on taking 6MP. In our series, 20 patients tolerated 6MP, but it was ineffective in 8 CD cases, and valuable mainly in ulcerative colitis patients. | Ferenc Nagy Tamás Molnár Zoltán Szepes Klaudia Farkas Tibor Nyári János Lonovics | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 3 | Proteome analysis and its impact on the discovery of serological tumor markers显示文摘 | Ference C W Philip J J | 2001 | Clinica Chimica Acta2001，13，： | 1 |
| 4 | A haz- ard perception test for novice drivers显示文摘 | Scialfa C T Desehenes M C Ference J | 2011 | Accident A- nalysis and Prevention2011，43，1： | 1 |
| 5 | Analysis of TGF beta protein expression in aggressive fibromatosis (desmoid tumor)显示文摘 | Ferenc T Stalinska L Turant M Sygut J Tosik D Dziki A | 2006 | Pol J Pathol2006，57，： | 1 |
| 6 | Poisonings with Amanita phalloides 显示文摘 | Ferenc T Lukasiewicz B Cieccwierz J | 2009 | Med Pr2009，60，5： | 1 |
| 7 | Improved magneto- optic modulator for ultrafast current pulses 显示文摘 | Cottrell W J Ference T G Puzey K T | 2002 | IEEE Pho- tonics Technology Letters2002，14，5： | 1 |
| 8 | Aggressive fibromatosis(desmoid tumors):definition,occurrence,pathology,diagnostic problems,clinical behavior,genetic background显示文摘 | Ferenc T Sygut J Kopczynski J | 2006 | Pol J Pathol2006，57，1： | 1 |
| 9 | Recognizing Design Patterns in C+ + Programs with the Integration of Columbus and Maisa显示文摘 | R Ferenc J Gustafsson L Muller | 2002 | Acta Cybernetica Journal2002，15，： | 1 |
| 10 | Poisonings with Amanita phalloides 显示文摘 | Ferenc T Lukasiewicz B Ciecwierz J | 2009 | Med Pr2009，60，5： | 1 |
| 11 | Down-regulation of Bcl-2 and Akt induced by combination of photoactivated hypericin and genistein in human breast cancer cells显示文摘 | Ferenc P Solar P Kleban J | 2010 | J Photochem Photobiol B2010，98，1： | 1 |
| 12 | Artificial neural network approach for predicting transient water levels in a multilayered groundwater system under variable state, pumping, and climate conditions显示文摘 | EMERY C J FERENC S MARY P | 2003 | Journal of Hydrologic Engineering2003，8，6： | 1 |
| 13 | Down-regulation of Bcl-2 and Akt induced by combination of photoactivated hypericin and genistein in human breast cancer cells显示文摘 | Ferenc P Solar P Kleban J | 2010 | J Photochem Photobiol B2010，98，1： | 1 |
| 14 | Aggressive fibromatosis (desmoid tumors):definition,occurrence,pathology,diagnostic problems,clinical behavior,genetic background显示文摘 | Ferenc T Syqut J Kopczynski J | 2006 | Pol J Pathol2006，57，1： | 1 |
| 15 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 16 | Managing the career plateau显示文摘 | Ference T P Stoner J A Warren E K | 1977 | Academy of Management Review1977，2，4： | 1 |
| 17 | Managing the career plateau显示文摘 | FERENCE T P STONER J A WARREN E K | 1977 | Academy of Management Review1977，2，24： | 1 |
| 18 | A hazard perception test for novice drivers 显示文摘 | Scialfa C T Deschnes M C Ference J | 2011 | Accident Analysis and Prevention2011，43，1： | 1 |
| 19 | A hazard perception test for novice drivers 显示文摘 | SCIALFA C T DESCHENES M C FERENCE J | 2011 | Accident Analysis and Prevention2011，43，1： | 1 |
| 20 | Evolutionary aspects of autotrophy显示文摘 | QUAYLE J R FERENCI T | | 0，，02： | 1 |
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