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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | WNT and betacatenin signalling:diseases and therapies显示文摘 | Moon R T Kohn A D De Ferrari G V | 2004 | Nature Reviews Genetics2004，5，9： | 1 |
| 3 | Chcmokinc (C-X-C motif') ligand (CXCL)10 in autoimmune diseases 显示文摘 | Antonelli A Ferrari SM G-iuggioli D | 2014 | Autoimmun Rev2014，13，3： | 1 |
| 4 | 50 Hz magnetic fields of varying flux intensity affect cell shape changes in invertebrate immunocytes: the role of potassium ion channels显示文摘 | Ottaviani E Malagoli D Ferrari A | 2002 | Bioelectromagnetics2002，23，4： | 1 |
| 5 | Kinetic mechanism and mierostruerure during the formation of Si3N4 matrix in Si3N4 MoSi2 composites显示文摘 | Beruto D T Ferrari A Giordani M Marino F | 2003 | Materials Science and Engineering2003，，355： | 1 |
| 6 | New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation显示文摘 | Songia S Gnocchi P Ferrari M Fornasiero C D'Alessio R | 1999 | J Immunol1999，162，12： | 1 |
| 7 | Laparoscopy- assisted abdominal aortic aneurysm repair: early and middle-term results of a consecutive series of 122 cases 显示文摘 | Ferrari M Adami D Del Corso A | 2006 | J Vase Surg2006，43，4： | 1 |
| 8 | Threedimensional quantitative structure-activity relationship analysis of a set of plasmodium falciparmn dihydrofolate reductase inhibitors using a pharmacophore generation approach 显示文摘 | Parenti M D Paeehioni S Ferrari A M | 2004 | J Med Chem2004，47，： | 1 |
| 9 | Faraday current sensor with temperature monitoring显示文摘 | Perciante C D Ferrari J A | 2005 | Applied Optics2005，44，32： | 1 |
| 10 | Antifungal drug resistance mecha- nisms in fungal pathogens from the perspective of transcriptional gene regulation 显示文摘 | Sanglard D Coste A Ferrari S | 2009 | FEMS Yeast Res2009，9，7： | 1 |
| 11 | Efficacy of Metschnikowla fructicola ( Shemer ) against post-harvest soft fruit (berries) rots in northern Italy (Trentlno) 显示文摘 | Prodorutti D Ferrari A Pellegrini A | 2008 | IOBC/WPRS Bulletin2008，39，： | 1 |
| 12 | An analysis of spatial variation in the nitrogen content of leaves from different horizons within a canopy显示文摘 | Charles~Edwards D A Stutzel H Ferraris R | 1987 | Ann Bot1987，60，： | 1 |
| 13 | Characterization of hepatitis B virus(HBV)-specific T-cell dysfunction in chronic HBV infection显示文摘 | Boni C Fisicaro P Valdatta C Amadei B Di Vincenzo P Giuberti T Laccabue D Zerbini A Cavalli A Missale G Bertoletti A Ferrari C | 2007 | J Virol2007，81，8： | 1 |
| 14 | Isolation and selection of native microorganisms for the aerobic treatment of simulated dairy wastewaters 显示文摘 | LOPERENA L FERRARI M D DIAZ A L | 2009 | Bioresource Technology2009，100，5： | 1 |
| 15 | P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death 显示文摘 | Ferrari D Los M Manuel K A | 1999 | FEBS Lett1999，477，1： | 1 |
| 16 | 查看详情显示文摘 | Sun Z P Hasan T Torrisi F Popa D Privitera Wang F Q Bonac-corso F Basko D M Ferrari A C | | 0，，： | 1 |
| 17 | Transcriptional activation of the neuronal peripherin-encoding gene depends on a G+C-rich element that binds Sp1 in vitro and in vivo显示文摘 | Desmarais D Royal A | 1995 | Gene1995，159，2： | 1 |
| 18 | Prion protein expression in different species:Analysis with a panel of new mAbs 显示文摘 | Zanusso G Liu D Ferrari S Hegyi I Yin X Aguzzi A | 1998 | Proc Natl Acad Sci USA1998，95，15： | 1 |
| 19 | Magnetic crosstalk minimization in optical current sensors显示文摘 | PercianteC D Ferrari J A | 2008 | IEEE Transactions on Instrumentation and Measurement2008，57，10： | 1 |
| 20 | Oral fat load effects on inflammation and endothelial stress markers in healthy subjeets显示文摘 | Derosa G Ferrari I D' Angelo A | 2009 | Heart and Vessels2009，24，3： | 1 |
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