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| 1 | Bariatric surgery in patients with non-alcoholic fatty liver disease-from pathophysiology to clinical effects显示文摘Non-alcoholic fatty liver disease(NAFLD) is increasingly recognized as a significant liver disease,and it covers the disease spectrum from simple steatosis with a risk of development of non-alcoholic steatohepatitis(NASH) to fibrosis,subsequent cirrhosis,end-stage liver failure,and liver cancer with a potential need for liver transplantation.NAFLD and NASH are closely related to obesity,metabolic syndrome,and type 2 diabetes(T2 D).The role of gut hormones,especially glucagon-like peptide 1(GLP-1),is important in NAFLD.Bariatric surgery has the potential for inducing great weight loss and may improve the symptoms of metabolic syndrome and T2 D.Recent data demonstrated significant effects of bariatric surgery on GLP-1 and other gut hormones and important lipid metabolic and inflammatory abnormalities in the pathophysiology of NAFLD.Therefore,bariatric surgery may reverse the pathological liver changes in NAFLD and NASH patients.In the present review,we describe NAFLD and NASH pathophysiology and the primary effects of bariatric surgery on metabolic pathways.We performed a systematic review of the beneficial and harmful effects and focused on changes in liver disease severity in NAFLD and NASH patients.The specific focus was liver histopathology as assessed by the invasive liver biopsy.Additionally,we reviewed several non-invasive methods used for the assessment of liver disease severity following bariatric surgery. | Tea L Laursen Christoffer A Hagemann Chunshan Wei Konstantin Kazankov Karen L Thomsen Filip K Knop Henning Grønbæk | 2019 | World Journal of Hepatology2019，11，2： | 11 |
| 2 | Clinical and economic consequences of pancreatic fistula after elective pancreatic resection显示文摘BACKGROUND:Postoperative pancreatic fistula is the main cause of morbidity after pancreatic resection.This study aimed to quantify the clinical and economic consequences of pancreatic fistula in a medium-volume pancreatic surgery center.METHODS:Hospital records from patients who had undergone elective pancreatic resection in our department were identified.Pancreatic fistula was defined according to the International Study Group on Pancreatic Fistula(ISGPF).The consequences of pancreatic fistula were determined by treatment cost,hospital stay,and out-patient follow-up until the pancreatic fistula was completely healed.All costs of the treatment are calculated in Euros.The cost increase index was calculated for pancreatic fistula of grades A,B,and C as multiples of the total cost for the no fistula group.RESULTS:In 54 months,102 patients underwent elective pancreatic resections.Forty patients(39.2%) developed pancreatic fistula,and 54 patients(52.9%) had one or more complications.The median length of hospital stay for the no fistula,grades A,B,and C fistula groups was 12.5,14,20,and 59 days,respectively.The hospital stay of patients with fistula of grades B and C was significantly longer than that of patients with no fistula(P<0.001).The median total cost of the treatment was 4952,4679,8239,and 30 820 Euros in the no fistula,grades A,B,and C fistula groups,respectively.CONCLUSIONS:The grading recommended by the ISGPF is useful for comparing the clinical severity of fistula and for analyzing the clinical and economic consequences of pancreatic fistula.Pancreatic fistula prolongs the hospital stay and increases the cost of treatment in proportion to the severity of the fistula. | Filip Ceka Bohumil Jon Zdeněk ubrt Alexander Ferko | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 3 | Pancreatic Castleman disease treated with laparoscopic distal pancreatectomy显示文摘BACKGROUND: Castleman disease is an uncommon lympho-proliferative disorder most frequently occurring in the mediastinum. Abdominal forms are less frequent, with pancreatic localization of the disease in particular being extremely rare. Only seventeen cases have been described in the world literature. METHOD: This report describes an interesting and unusual case of pancreatic Castleman disease treated with laparoscopic resection. RESULTS: A 48-year-old woman presented with epigastric pain. CT scan showed a well-encapsulated mass on the ventral border of the pancreas. Endosonography with fine needle aspiration biopsy was performed. Biopsy showed lymphoid elements and structures of a normal lymph node. The patient was treated with laparoscopic distal pancreatectomy. The pancreas was transected with a Ligasure device and the pancreatic stump was secured with a manual suture. One year after surgery the patient was complaint-free and showed no signs of recurrence of the disease. CONCLUSIONS: Laparoscopic distal pancreatectomy is a feasible and safe method for the treatment of lesions in the body and tail of the pancreas. Transection of the pancreas with a Ligasure device offers the advantages of low bleeding and low risk of pancreatic fistula. | Filip ecka Alexander Ferko Bohumil Jon Zdeněk ubrt Petra Kaparová Rudolf Repák | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 4 |
| 4 | Long-term survival of a patient after resection of a gastrointestinal stromal tumor arising from the pancreas显示文摘BACKGROUND:Gastrointestinal stromal tumors (GISTs) may arise in any part of the gastrointestinal tract;extragastrointestinal locations are extremely rare.Only a few cases of extragastrointestinal stromal tumor arising from the pancreas were reported.None of the reports described a long-term follow-up of the patients.METHOD:This report describes an interesting and unusual case of GIST arising from the pancreas.RESULTS:A 74-year-old female presented with a palpable abdominal mass.CT scan showed a large mass 11×8×4 cm originating from the tail of the pancreas.Percutaneous biopsy revealed a GIST predominantly with spindle cells,but some parts also contained epitheloid cells.The patient was treated by distal pancreatic resection with splenectomy.Immunohistochemistry of the tumor showed a staining pattern characteristic of GIST.The patient has achieved a long-term survival of five years and six months without any sign of recurrence of the disease.CONCLUSION:This is the first reported case of an extragastrointestinal stromal tumor arising from the pancreas treated surgically,with a long-term survival. | Filip eka Bohumil Jon Alexander Ferko Zdeněk ubrt Dimitar H Nikolov Věra Tyová | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 3 |
| 5 | The effect of microstructure on the mechanical properties of two-phase titanium alloys显示文摘 | R Filip K Kubiak W Ziaja J Sieniawski | 2002 | Journal of Materials Processing Tech2002，，1： | 3 |
| 6 | 等径角挤压对Cu-0.81Cr-0.07Zr合金第二相颗粒分布、硬度和电导率的影响显示文摘研究在室温和300℃下等径角挤压(ECAP)对Cu-0.81Cr-0.07Zr合金中第二相分布的影响,及其对硬度和电导率的影响。显微组织表征表明,经ECAP后,粗大的富Cr颗粒面积分数减小,这是由于塑性变形导致Cr的溶解。在室温下进行4道次ECAP后,由于固溶体中较高的Cr含量和基体中较高的缺陷密度导致电子散射的增加,合金的电导率下降了12%。仅在ECAP样品中观察到的Cu晶格常数的减小和差示扫描量热分析(DSC)过程中发生的放热反应证实了这些结果。经ECAP后的时效热处理促进额外的硬化效果和导电性的完全恢复,这是由于部分溶解颗粒的再沉淀造成的。在室温下进行4道次ECAP,然后在380℃时效处理1 h的合金具有更高的硬度(191 HV)和电导率(83.5%(IACS))。 | Filipe CALDATTO DALAN Gisele Ferreira de LIMA ANDREANI Dilermando Nagle TRAVESSA Ilshat Albertovich FAIZOV Svetlana FAIZOVA Kátia Regina CARDOSO | 2022 | Transactions of Nonferrous Metals Society of China2022，32，1： | 2 |
| 7 | Intra-abdominal drainage following pancreatic resection:A systematic review显示文摘AIM: To study all the aspects of drain management in pancreatic surgery.METHODS: We conducted a systematic review according to the PRISMA guidelines. We searched the Cochrane Central Registry of Controlled Trials,EMBASE,Web of Science,and Pub Med(MEDLINE) for relevant articles on drain management in pancreatic surgery. The reference lists of relevant studies were screened to retrieve any further studies. We included all articles that reported clinical studies on human subjects with elective pancreatic resection and that compared various strategies of intra-abdominal drain management,such as drain vs no drain,selective drain use,early vs late drain extraction,and the use of different types of drains. RESULTS: A total of 19 studies concerned with drain management in pancreatic surgery involving 4194 patients were selected for this systematic review. We included studies analyzing the outcomes of pancreatic resection with and without intra-abdominal drains,studies comparing early vs late drain removal and studies analyzing different types of drains. The majority of the studies reporting equal or superior results for pancreatic resection without drains were retrospective and observational with significant selection bias. One recent randomized trial reported higher postoperative morbidity and mortality with routine omission of intraabdominal drains. With respect to the timing of drain removal,all of the included studies reported superior results with early drain removal. Regarding the varioustypes of drains,there is insufficient evidence to determine which type of drain is more suitable following pancreatic resection. CONCLUSION: The prophylactic use of drains remains controversial. When drains are used,early removal is recommended. Further trials comparing types of drains are ongoing. | Filip Cecka Martin Lovecek Bohumil Jon Pavel Skalicky Zdeněk Subrt Cestmír Neoral Alexander Ferko | 2015 | World Journal of Gastroenterology2015，21，40： | 2 |
| 8 | Surgical Technique in Distal Pancreatectomy: A Systematic Review of Randomized Trials显示文摘 | Filip ?e?ka Bohumil Jon Zdeněk ?ubrt Alexander Ferko Masahiko Hirota | 2014 | BioMed Research International2014，，： | 2 |
| 9 | Vendor Selection and Evaluation: An Activity Based Costing Approach显示文摘 | Filip R Jozef K | 1996 | Europer Journal of Operational Research1996，，96： | 1 |
| 10 | The effect of microstructure on the mechanical properties of two-phase Titanium alloys 显示文摘 | Filip R Kubiak K Ziaja W | 2003 | Journal of Materials Processing Technology2003，133，： | 1 |
| 11 | A model for radi- ation-induced bystander effects, with allowance for spatial po- sition and the effects of cell turnover显示文摘 | Little M P Filipe J A N Prise K M | 2005 | Journal of Theoreti- cal Biology2005，232，3： | 1 |
| 12 | Thermal analysis of bulk carbon-carbon composite and friction products derived from it during simulated aircraft braking显示文摘 | KATARZYNA P B ANDERSON K B SZYMANSKI T KRKOSKA M FILIP P | 2007 | Carbon2007，45，3： | 1 |
| 13 | Amino acids profile of Serbian unifloral honeys显示文摘 | Jelena K Jelena T Filip A | 2013 | Journal of the Science of Food and Agricuhure2013，93，13： | 1 |
| 14 | Performance of ceramic enhanced phenolic matrix brake lining materials for automotive brake linings显示文摘 | Hee K W Filip P | 2005 | Wear2005，259，712： | 1 |
| 15 | The effect of microstruzture on the mechanical properties of two-phase titanium alloys 显示文摘 | FILIP IL KUBIAK K ZIAJA W SIENIAWSKI J | 2003 | Journal of Materials Processing Technology2003，133，： | 1 |
| 16 | The effect of microstructure on the meehmlical properties of two-phase titanium 显示文摘 | Filip R Kubiak K Ziaja W | 2003 | Journal of Mate- rials Processing Technology2003，133，： | 1 |
| 17 | Two-and three-dimensional cadmium-organic frameworks with trimesic acid and 4,4′-trimethylenedipyridine显示文摘 | Filipe A Almeida P Jacek K | 2004 | Inorg Chem2004，43，： | 1 |
| 18 | Physicochemical characterization of ezetimibe and its impurities显示文摘 | FILIP K BANKOWSKI K SIDORYK K | 2011 | J M ol Struct2011，991，1： | 1 |
| 19 | Metabotropic glutamatergic receptors and their ligands in drug addiction显示文摘 | Pomierny-Chamioo L Rup K Pomierny B Niedzielska E Kalivas PW Filip M | 2014 | Pharmacol Ther2014，142，3： | 1 |
| 20 | Performance of ceramic enhanced phenolic matrix brake lining materials for automotive brake linings 显示文摘 | Hee K W Filip P | 2005 | Wear2005，259，712： | 1 |
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