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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | MODIFIED MELT TEXTURING PROCESS FOR YBCO BASED ON THE POLYTHERMIC SECTION YO1.5-BA0.4CU0.6O IN THE Y-BA-CU-O PHASE DIAGRAM AT 0.21 BAR OXYGEN PRESSURE显示文摘 | Krabbes G Schatzle P Bieger W Wiesner U Stover G Wu M Strasser T Litzkendorf D Fischer K Gornert P | | 0，，： | 2 |
| 3 | Cell type specificity of the human endoglin promoter显示文摘 | Guaulich W Nettelbeck D M Fischer D | 1999 | Gene1999，227，1： | 1 |
| 4 | Development of high performance multifilamentary Nb-Ti-Ta superconductor for LHC insertion quadrupoles 显示文摘 | Lee P J Fischer C M Larbalestier D C | 1999 | IEEE Trans Applied Superconductivity1999，9，2： | 1 |
| 5 | Raffinose improves 24-hour lung preservation in low potassium dextran glucose solution:a histologic and ultrastructural analysis显示文摘 | Fischer S Hopkinson D Liu M Y | 2001 | Ann Thorac Surg2001，71，： | 1 |
| 6 | Parturition at term:parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment显示文摘 | Winkler M Fischer D C Ruck P | 1999 | Hum Reprod1999，14，： | 1 |
| 7 | Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase: acetyl-CoA carboxylase-malonyl- CoA axis 显示文摘 | ATKINSON L L FISCHER M A LOPASCHUK G D | 2002 | J Biol Chem2002，277，29： | 1 |
| 8 | Knowledge interactions between universities and industry in Austria:sectoral patterns and determinants显示文摘 | Schartinger D Rammer C Fischer M M | | 0，，03： | 1 |
| 9 | Using the transform approximation method to analyzed queues with heavy-tailed service显示文摘 | Shortle J F Fischer M J Gross D | 2003 | Journal of Probability and Statistical Science2003，1，1： | 1 |
| 10 | In vivo fracture resistance of implant-supported all-ceramic restorations显示文摘 | Yildirim M Fischer H Marx R Edelhoff D | 2003 | J Prosthet Dent2003，90，4： | 1 |
| 11 | RAPD variation in relation to population size and plant fitness in the rare Gentianella germanica (Gentianaceae) 显示文摘 | FISCHER M MATTHIES D | 1998 | American Journal of Botany1998，85，： | 1 |
| 12 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lüddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 13 | A dose-finding study of aspirin for chemoprevention utilizing rectal mucosal prostaglandin E (2) levels as a biomarker显示文摘 | Sample D Wargovich M Fischer SM | | 0，，03： | 1 |
| 14 | Bibout, Mixed- Metal Triple- Decker Sandwich Complexes with the Porphyrin/Phthalocyanine/Porphyrin Ligand System 显示文摘 | D Chabach A De Cian J Fischer R Weiss M E1 M | 1996 | Angew Chem Iht Ed Engl1996，35，： | 1 |
| 15 | Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of activated macrophages显示文摘 | Hauk TG Müller A Lee J Schwendener R Fischer D | 2008 | Exp Neurol2008，209，2： | 1 |
| 16 | The physiology and proteomics of drought tolerance in maize: early stomatal closure as a cause of lower tolerance to short-term dehydration显示文摘 | Benesova M Hola D Fischer L | 2012 | PLos one2012，7，38： | 1 |
| 17 | Mechanisms of resistance to bispyribac-sodium in an Echinochloa phyllopogon accession显示文摘 | Fischer A J Bayer D E Carriere M D | 2000 | Pestic Biochem Physiol2000，68，： | 1 |
| 18 | Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture显示文摘 | Fischer D Pavlidis M Thanos S | 2000 | Invest Ophthalmol Vis Sci2000，41，12： | 1 |
| 19 | Efficiency droop due to electron spill-over and limited hole injection in Ⅲ-nitride visible light-emitting diodes employing lattice-matched InAlN electron blocking layers显示文摘 | Choi S Ji M H Kim J Kim H J Satter M M Yoder P D Ryou J H Dupuis R D Fischer A M Ponce F A | | 0，，16： | 1 |
| 20 | A comparative empirical examination of extent of disclosure by private and public colleges and universities in the United States显示文摘 | Gordona T Fischer M Malonec D | 2002 | Journal of Accounting and Public Policy2002，21，： | 1 |
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