|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | In vitro activities of acetonic extracts from leaves of three forage legumes(Calliandra calotyrsus,Gliricidia sepium and Leucaena diversifolia) on Haemonchus contortus显示文摘Objective:To assess ovicidal activity of three acetonic extracts from the leaves of three forage legume,Calliandra calotyrsus(C.calotyrsus),Gliricidia sepium(G.sepium) and Leucaena diversifolia(L.diversifolia) in vitro on Haemonchus contortus(H.contortus).Methods:Eggs were exposed for 24 hours to five different concentrations(0.075,0.15,0.3,0.6 and 1.25 mg/mL) of acetonic extracts at room temperature(24℃).Distilled water and 0.4%Tween were used in the bioassay as negative controls.Results:The later did not affect embryonation and egg hatching of H.contortus.Conversively,significant effects were obtained with the acetonic extracts of leaves of all three plants and the maximum activity was observed with the highest concentration (1.25 mg/mL).The acetonic extract of G.sepium was found to be more active(2.9%and 0.0% for embryonation and egg hatching,respectively) than the other substances 16.5%and 33.5%, respectively for C.calothyrsus,33.7%and 33.3%,respectively for L diversifolia.Conclusions: These results suggest that the three forage legumes do possess ovicidal properties and further studies on larvae should be carried out. | Wabo Pone J Kenne Tameli Florence Mpoame Mbida Pamo Tedonkeng E Bilong Bilong CF | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，2： | 2 |
| 3 | Treatment of IgM Antibody Associated Polyneuropathies Using Rituximab显示文摘 | PESTRONK A FLORENCE J MILLER T | 2003 | J Neurol Neurosurg Psychiatry(S0022-3050)2003，74，： | 1 |
| 4 | Percutaneous absorption of inorganic lead compounds显示文摘 | Stauber J L Florence T M Gulson G L | 1994 | Sci Total Environ1994，145，： | 1 |
| 5 | The Effect of culture-medium on metal toxicity to the marine diatom Nitzschia-closterium and the fresh-water green-alga Chlorella-pyrenoidosa 显示文摘 | STAUBER J L FLORENCE T M | 1989 | Water Res1989，23，7： | 1 |
| 6 | Nanospheres of cycloporin A:Poor oralabsorption in dogs显示文摘 | Woolfe J Florence AT | 1999 | Int J Pharm1999，183，1： | 1 |
| 7 | Thermoelastic stress due to disturbance of uniform heat flow by an insulated ovaloid hole显示文摘 | FLORENCE A L GOODIER J N | 1960 | ASME Journal of Applied Mechanics1960，82，： | 1 |
| 8 | Dynamic triaxial tests of high strength concrete显示文摘 | Gran J K Florence A L Colton J D | 1989 | Journal of Engineering Mechanics ASCE1989，115，5： | 1 |
| 9 | Biodistribution and oxidative stress effects of a systemically-introduced commercial eeria engineered nanomaterial 显示文摘 | Yokel R Florence R Unrine J | 2009 | Nanotoxicolog2009，3，3： | 1 |
| 10 | The preparation and properties of niosomes-non-ionic surfactant vesicles显示文摘 | Baillie A J Florence A T Hume L R | 1985 | J Pharm Pharmacol1985，37，12： | 1 |
| 11 | Dynamic triaxial test of high-strength concrete显示文摘 | Gran J K Florence A L Colton J D | 1989 | Journal of Engineering Mechanics1989，115，5： | 1 |
| 12 | Bioavailability of Al in alum-treated drinking water 显示文摘 | Stauber J L Florence T M Davies C M | 1999 | J Am Water Works Assoc1999，91，： | 1 |
| 13 | Cell death by apoptosis: Basic Concepts and discase relevance for the gastroenterologist 显示文摘 | Florenci AG Gregory J | 1996 | Gastroenterology1996，110，4： | 1 |
| 14 | Processes influencing dissolved iron distributions below the surface at the Atlantic Ocean Celtic Sea shelf edge显示文摘 | Florence N Peter J Matt M | 2007 | Marine Chemistry2007，104，： | 1 |
| 15 | 查看详情显示文摘 | G M Espallargas L Brammer J van de Streek K Shankland A J Florence H Adams | | 0，，： | 1 |
| 16 | Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency 显示文摘 | Jani P Halbert G W Langridge J Florence A T | 1990 | J Pharm Pharmacol1990，42，12： | 1 |
| 17 | The preparation and properties of niosomes nonionic surfactant vesicles 显示文摘 | Baillie A J Florence AT Hume LR: | 1985 | J Pharm Pharmacol1985，37，： | 1 |
| 18 | Studies on electrodeposition of copper from methanesulphonic acid bath 显示文摘 | FLORENCE F J NISHA P RAJENDRAN S | 2010 | International Journal of ChemTech Research2010，3，3： | 1 |
| 19 | The uptake and translocation of latex nanospheres and mierospheres after oral administration to rats显示文摘 | Jani P Halbert G W Langridge J Florence A T | 1989 | J Pharm Pharmacol1989，41，12： | 1 |
| 20 | In vitro hepatoprotective and antioxidant activities of crude extract and i- solated compounds from Ficus gnaphalocarpa显示文摘 | Hubert D J Dawe A Florence N T | 2011 | Inflammop- harmacology2011，19，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员