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	题名	作者	年代	出处	被引量
1	Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging.	Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert	2022	Stroke & Vascular Neurology2022，7，2：	7
2	Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p161NK4a 显示文摘	Janzen V Forkert R Fleming HE	2006	Nature2006，443，7110：	1
3	Exposure to trichlomethylene and its metabolites causes impairment of sperm fertilizing ability in mice显示文摘	XU H TANPHAICHITR N FORKERT P G	2004	Toxicol Sci2004，82，2：	1
4	Stem-cell ageing modified by the cyclin-dependent kinase inhibitor pl6INK4a 显示文摘	Janzen V Forkert R Fleming H E	2006	Nature2006，443，7110：	1
5	Response of lung volumes to inhaled salbutamol in a large population of patients with severe hyperinflation显示文摘	Newton M O'Donnell DE Forkert L	2002	Chest2002，121，4：	1
6	Ex vivo targeting of p21 permits relative expansion of human hematopoietic stem cells显示文摘	Stier S Cheng T Forkert R	2003	Blood2003，102，4：	1
7	Identifieation oftriehloroethylene and its metabolites in human seminal fluidofworkers exposed to trichloroethylene显示文摘	Forkert PG Lash L Tardif R		Drug MetabDispos0，200，：	1
8	Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a显示文摘	Janzen U Forkert R Fleming HE	2006	Natue2006，443，：	1
9	Metabolism of ethyl carbamate by pulmonary cytochrome P450 and earboxylesterase isozymes: Involvement of CYP2E1 and hydrotase A显示文摘	Forkert P G Lee R P	1997	Toxicology and Applied Pharmacology1997，146，2：	1
10	Mechanisms of 1,1-dichloroethylene-induced cytotoxicity in lung and liver显示文摘	Forkert PG	2001	Drug Metab Rev2001，33，1：	1
11	Osteopontin is a hemato- poietie stem cell niche component that negatively regulates stem cell pool size显示文摘	STIER S KO Y FORKERT R	2005	J Exp Med2005，201，11：	1
12	Nerve growth factor in rheumatic diseases显示文摘	Seidel M F Herguijuela M Forkert R	2010	Semin Arthritis rheum2010，40，2：	1
13	Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size显示文摘	Stier S Ko Y Forkert R	2005	J Exp M ed2005，201，11：	1
14	Response of lung volumes to inhaled salbutamol in a large population of patients with severe hyperinflation 显示文摘	Newton MF O' Donnell DE Forkert L	2002	Chest2002，121，：	1
15	Exposure to trichloroethylene and its metabolites causes impairment of sperm fertilizing ability in mice 显示文摘	Xu H Tanphaichitr N Forkert PG	2004	Toxicol Sci2004，82，2：	1
16	Comparison of 10 TTP and Tmax estimation techniques for MR perfusion-diffusion mismatch quantification in acute stroke显示文摘	FORKERT N D KAESEMANN P TRESZL A	2013	AJNR Am J Neuroradiol2013，34，9：	1
17	Evaluation of bronchodilator responses in patients with 'irreversible' emphysema显示文摘	O'Donnell DE Forkert L Webb KA	2001	Eur Respir J2001，18，：	1
18	Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a显示文摘	Janzen V Forkert R Fleming H E	2006	Nature2006，443，7110：	1
19	Response of lung volumes to inhaled salbutamol in a large population of putients with severe hyperinflation 显示文摘	Newton M F O'Donnell D E Forkert L	2002	Chest2002，121，4：	1
20	Mechanisms of lung tumorigenesis by ethyl carbamate and vinyl carbamate显示文摘	Forkert P G	2010	Drug Metab Rev2010，42，2：	1

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