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| 1 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Receptor-ligand binding assays: technologies and applications 显示文摘 | JONG L A UGES D R FRANKE J P BISCHOFFR | 2005 | JChromatogr: B2005，829，12： | 1 |
| 4 | Towards a sustainable and efficient use of manure in agriculture:The Dutch case显示文摘 | Frank J D Nico J P H | | 0，，： | 1 |
| 5 | Cytochrome P450 family member CYP704B2 catalyzes the omega } - hydrnxylation of fatty acids and is required for anther cutin biosynthesis and pollen exine formation in rice 显示文摘 | Li H Pinot F Sauveplane V Werck-Reichhart D Diehl P Schreiber L Franke R Zhang P Chert L Gao Y Liang W ZhangD | 2010 | Plant Cell2010，22，1： | 1 |
| 6 | Strong tracking filtering of nonlinear time-varying stochastic systems with colored noise: application to parameter estimation and empirical robustness analysis 显示文摘 | FRANK P M | 1996 | Int J Control1996，65，2： | 1 |
| 7 | Historical Perspective on Fifteen Years of Laser Damage Thresholds at LLNL显示文摘 | Rainer F Frank P Marco D | 1993 | SPIE Proceedings1993，2114，： | 1 |
| 8 | A Real Time Estimation Approach to Time-varying Time Delay and Parameters of NARX Processes显示文摘 | Zhou D H Frank P M | 2000 | Comput Chem Eng2000，23，1112： | 1 |
| 9 | Strong tracking Kalman filtering of nonlinear time-varying stochastic systems with coloured noise: application to parameter estimation and empirical robustness analysis显示文摘 | Zhou D H Frank P M | 1996 | Int J Control1996，65，2： | 1 |
| 10 | Are symptoms of anxiety and depression risk factors for hypertension显示文摘 | Jonas B Franks P Ingram D | 1997 | Arch Fam Med1997，6，： | 1 |
| 11 | Two toxic kaurene glycosides from the burrs of Xanthium pungens显示文摘 | Macleod J K Moeller P D Franke F P | 1990 | J Nat Prod1990，53，2： | 1 |
| 12 | Strong tracking filtering of nonlinear time-varying stochastic systems with coloured noise: application to parameter estimation and empirical robustness analysis 显示文摘 | Zhou D H Frank P M | 1996 | International Journal of Control1996，65，2： | 1 |
| 13 | Dexamethasone increase superoxide dismutase activity in serum-free rat fetal lung organ cultures显示文摘 | Randhawa P Hess M Frank L Masssro D | 1986 | Pediatr Res1986，20，： | 1 |
| 14 | Effects of alternative food on cannibalism and herbivore suppression by carabid larvae显示文摘 | Frank S D Shrewsbury P M Denno R F | 2010 | Ecological Entomology2010，35，： | 1 |
| 15 | Generalized scale length for two dimensional effects in MOSFETs显示文摘 | D J Frank Y Taur H-S P Wong | 1998 | IEEE ED Lett1998，19，10： | 1 |
| 16 | Susceptibility for alcoholism:DRD4 exonⅢ polymorphism:a case-control and a family-based association approach显示文摘 | Franke P Wang T Mthen MM Knapp M Neith H Lichtermann D Zur Capellen KM Sander T Propping P Maier W | | 0，，03： | 1 |
| 17 | Numerical simulation and experimental investigation of gas-solid two-phase flow in a horizontal channel 显示文摘 | Frank T Schade K P Petrak D | 1993 | Int J Multiphase Flow1993，19，： | 1 |
| 18 | Redox flow cells for energy conversion显示文摘 | De Leon C P Frías-Ferrer A González-García José Szánto D A Walsh Frank C | 2006 | Journal of Power Sources2006，160，1： | 1 |
| 19 | A new combined HIV p24 antigen and anti-HIV-1/2/O screening assay显示文摘 | SUSANNE P HEDWIG D FRANK L | 2005 | Journal of Molecular Biology2005，304，： | 1 |
| 20 | Tensor methods for nonlinear e- quations 显示文摘 | Schnabel R B Frank P D | 1984 | SIAM Journal on Numerical Anal-ysis1984，21，5： | 1 |
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