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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels显示文摘 | Fu H Li W Lao Y Luo J Lee NT Kan KK Tsang HW Tsim KW Pang Y Li Z Chang DC Li M Han Y | 2006 | 中国生物学文摘2006，20，10： | 10 |
| 3 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 4 | Defunctionalization of functionalized carbon nanotubes显示文摘 | Fu K Huang W J Lin Y | 2001 | Nano Letters2001，1，8： | 1 |
| 5 | The veterinary antibiotic oxytetracycline and Cu influence functional diversity of the soil microbial community 显示文摘 | KONG W D ZHU Y G FU B J | 2006 | Environmental Pollution2006，143，： | 1 |
| 6 | Study on multiplestep incremental air-bending forming of sheet metal with springback model and FEM simulation显示文摘 | Fu Z M Mo J H Zhang W X | 2009 | International Journal of Advanced Manufacturing Technology2009，45，： | 1 |
| 7 | The veterinary antibiotic oxytetracyeline and Cu influence functional diversity of the soil microbial community 显示文摘 | Kong W D Zhu Y G Fu B J | 2006 | Environmental Pollution2006，143，1： | 1 |
| 8 | Tanshinone ]I A protects car- diac myocytes against oxidative stress-triggered damage and apopto- sis 显示文摘 | Fu J J Huang H W Liu J J | 2007 | Eur J Pharmacol2007，568，123： | 1 |
| 9 | Concentration and mode of occurrence of trace elements in marine oil shale from the Bilong Co area,northern Tibet,China显示文摘 | FU X G WANG J ZENG Y H TAN F W FENG X L | | 0，，01： | 1 |
| 10 | The Late Triassic rift-related vol- canic rocks from eastern Qiangtang, northern Tibet (China): Age and tectonic implications显示文摘 | Fu X G Wang J Tan F W | 2010 | Gondwana Research2010，17，1： | 1 |
| 11 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 12 | Top-k typicality queries and efficient query answering methods on large databases显示文摘 | Hua M Pei J Fu A W C | 2009 | The International Journal on Very Large Data Bases(VLDB)2009，32，18： | 1 |
| 13 | Stability analysis of the partial double-layer forms derived from the complete double- layer reticulated dome 显示文摘 | Chen W J He Y L Fu G Y | 2001 | Journal of the International Association for Shell and Spatial Structures2001，42，137： | 1 |
| 14 | Preliminary research on bamboo degumming with xylanase 显示文摘 | FU J J YANG X X YU C W | 2008 | Biocatalysis and Biotransformation2008，25，5： | 1 |
| 15 | Mining N-most inter-esting itemsets 显示文摘 | FU A W C KWONG R W W TANG J | 2000 | ISMIS2000，12，4： | 1 |
| 16 | Effect of phenolic resin content on performance of carbon fiber reinforced paper-based friction ma- terial 显示文摘 | Fei J Li H J Fu Y W | 2010 | Wear2010，269，78： | 1 |
| 17 | Penalized Regression:the bridge versus the LASSO显示文摘 | Fu W J | | 0，，： | 1 |
| 18 | Spatial distribution of polychlorinated biphenyls (PCBs) and polybrominated biphenyl ethers (PBDEs) in an e-waste dismantling region in Southeast China: Use of apple snail (Ampullariidae) as a bioindicator显示文摘 | Fu J J Wang Y W Zhang A Q | 2011 | Chemosphere2011，82，5： | 1 |
| 19 | Biomechanical evaluation of various fixation methods for proximal extra-articular tibial fractures显示文摘 | Feng W Fu L Liu J | 2012 | J Surg Res2012，178，2： | 1 |
| 20 | SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress显示文摘 | Yang Y Fu W Chen J | 2007 | Nat Cell Biol2007，9，11： | 1 |
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