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| 1 | Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97显示文摘ALM To establish clone cells with different metastatic potential for the study of metastasis-related mechanisms. METHODS Cloning procedure was performed on parental hepatocellular carcinoma (HCC) cell line MHCC97. andbiological characteristics of the target clones selected by in vivo screening were studied.``RESULTS Two clones with high MHCC97-H and IowMHCC9--L1 metastatic potential were isolated from theparent cell line. Compared with MHCC97-L. MHCC97-H hadsmaller cell size average cell diameter 43 um vs 50 μmand faster in vitro and in vivo growth rate tumor celldoubling time was 34.2 h vs 60.0 h. The main ranges ofchromosomes were 5.5 58 in MHCC97-H and 57 62 inMHCC97-L. Boyden chamber in vitro invasion assay demonstrated that the number of penetrating cells through the artificial basement membrane was 137.5 - 11 .0) cellsfield for MHC_C99--H vs 17.7 - 6.3) field for MHCC97-L.The proportions of cells in GO Gl phase. S phase, and G_ M phase for MHCC97-H MHCC97-L were 0.56 6.65.0.28 0.25 and 0.l6 0.10, respectively, as measured by flow cytometry. The serum AFP levels in nude mice 5 wk after orthotopic implantation of tumor tissue were ( 24666 μg. L for MHCC97-H and (91- 66) μg' L 1 for MHCC97L. The pulmonary metastatic rate was 100% (10-10) vs40% 4- 10).``CONCLUSION Two clones of the same genetic background but with different biological behaviors were established, which could be valuable models for investigation on HCC metastasis. | Yan Li Zhao-You Tang Sheng-Long Ye Yin-Kun Liu Jie Chen Qiong Xue Jun Chen Dong-Mei Gao Wei-Hua Bao Liver Cancer Institute and Zhongshan Hospital of Fudan University (Former Liver Cancer Institute of Shanghai Medical University),Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，5： | 111 |
| 2 | Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein显示文摘AIM To compare the therapeutic effect andsignificances of multimodality treatment forhepatocellular carcinoma (HCC) with tumorthrombi in portal vein (PVTT).METHODS HCC patients (n = 147) with tumortrombi in the main portal vein or the first branchof portal vein were divided into four groups bythe several therapeutic methods. There wereconservative treatment group in 18 out ofpatients (group A); and hepatic artery ligation(HAL) and/or hepatic artery infusion (HAl)group in 18 patients (group B), in whompostoberative chemoembolization was doneperiodically; group of removal of HCC with PVTTin 79 (group C) and group of transcatheterhepatic arterial chemoembolization (TACE) orHAl and/or portal vein infusion (PVI) afteroperation in 32 (group D).RESULTS The median survival period was 12months in our series and the 1-, 3-, and 5-yearsurvival rates were 44.3%, 24.5% and 15.2%,respectively. The median survival times were 2,5, 12 and 16 months in group A, B, C and D,respectively. The 1-, 3- and 5-year survival rateswere 5.6%, 0% and 0% in group A; 22.2%,5.6% and 0% in group B; 53.9%, 26.9% and16.6% in group C; 79.3%, 38.9% and 26.8% ingroup D, respectively. Significant differenceappeared in the survival rates among the groups(P<0.05).CONCLUSION Hepatic resection with removalof tumor thrombi and HCC should increase thecurative effects and be encouraged for theprolongation of life span and quality of life forHCC patients with PVTT, whereas the besttherapeutic method for HCC with PVTT is withregional hepatic chemotherapy orchemoemblization after hepatic resection withremoval of tumor thrombi. | Jia Fan Zhi Quan Wu Zhao You Tang Jian Zhou Shuang Jian Qiu Zeng Chen Ma Xin Da Zhou Sheng Long Ye Liver Cancer Institute, Zhongshan Hospital, Fudan University Medical Center (Former Shanghai University), 136 Yixueyuan Road, Shanghai 200032, China | 2001 | World Journal of Gastroenterology2001，7，1： | 80 |
| 3 | Metastatic human hepatocellular carcinoma models in nude mice and cell line with metastatic potential显示文摘Metastatic human HCC model is needed for the studies on mechanism and intervention of metastatic recurrence. By using orthotopic implantation of histologically intact tissues of 30 surgical specimens, a patient like metastatic model of human HCC in nude mice (LCI-D20)and a Iow metastatic model of human HCC in nude mice LCI-D35 ) have been established. All mice with transplanted LCI-D20 tumors exhibited extremely high metastatic ability including spontaneous metastasis to liver, lungs, lymph nodes and peritoneal seeding.Remarkable difference was also found in expression of some of the invasiveness related genes and growth factors between the LCI-D20 and LCI-D35 tumors. PAI-Iincreased gradually following tumor progression in LCID20 model, and correlated with tumor size and AFP level,Phasic expression of tissue intercellular adhesion molecule-I in this model was also observed. Using corneal micropocket model, it was demonstrated that the vascular response induced by LCI-D20 tumor was stronger than that induced by LCI-D35 tumor. Similar report on metastatic human HCC model in nude mice and human HCC cell line with metastatic potential was rarely found in the literature. This LCI-D20 model has been widely used for the studies on intervention of metastasis, including antiangiogenesis, antisense approach, metalloproteinase inhibitor, differentiation inducer, etc. It is concluded that the establishment of metastatic human HCC model in nude mice and human HCC cell line with metastatic potential will provide important models for the in vivo and in vitro study of HCC invasiveness, angiogenesis as well as intervention of HCC recurrence. | Zhao-You Tang Fan-Xian Sun Jian Tian Sheng-Long Ye Yin-Kun Liu Kang-Da Liu Qiong Xue Jie Chen Jing-Lin Xia Lun-Xiu Qin Hui-Chuan Sun Lu Wang Jian Zhou Yan Li Zeng-Chen Ma Xin-Da Zhou Zhi-Quan Wu Zhi-Ying Lin Bing-Hui Yang Liver Cancer Institute of Fudan University and Zhongshan Hospital,Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，5： | 34 |
| 4 | Budd-Chiari syndrome:Diagnosis with three-dimensional contrast-enhanced magnetic resonance angiography显示文摘AIM:To evaluate the role of three-dimensional contrastenhanced magnetic resonance angiography (3D CE MRA) in the diagnosis of Budd-Chiari syndrome (BCS).METHODS: Twenty-three patients with BCS underwent 3D CE MRA examination, in which 13 cases were secondary to either hepatocellular carcinoma (11 cases), right adrenal carcinoma (1 case) or thrombophlebitis (1 case) and 10suffered from primary BCS. The patency of the inferior vena cava (IVC), hepatic and portal veins as well as the presence of intra- and extrahepatic collaterals, liver parenchymal abnormalities and porto-systemic varices were evaluated. Inferior vena cavography was performed in 10 cases. The diagnosis of IVC obstruction by 3D CE MRA was compared with that demonstrated by inferior vena cavography.RESULTS: The major features of BCS could be clearly displayed on 3D CE MRA. Positive hepatic venous signs included tumor thrombosis (9 cases), tumor compression (2 cases), nonvisualization (4 cases) and focal stenosis (2 cases). Positive IVC findings were noted as severe stenosis or occlusion (10 cases), tumor invasion (2 cases), thrombosis (3 cases), thrombophlebitis (1 case) and septum formation (3 cases). Intrahepatic collaterals were shown in 9 patients,2 of them with 'spider web' sign. The displayed extrahepatic collaterals included dilated azygos and hemi-azygos veins (13 cases) and left renal-inferior phrenic-pericardiophrenic veins (2 cases). The occlusion of the left intrahepatic portal veins was found in 2 cases. Porto-systemic varices were detected in 10 patients. Liver parenchymal abnormalities displayed by 3D CE MRA were enlargement of the caudate lobe (7 cases), heterogenous enhancement (18 cases) and complicated tumors (13 cases). Compared with the inferior vena cavography performed in 10 cases, the accuracy of 3D CE MRA was 100% in the diagnosis of IVC obstruction.CONCLUSION: 3D CE MRA can display the major features of BCS and provide an accurate diagnosis. | Jiang Lin Xiao-Hai Chen Kang-Rong Zhou Zu-Wang Chen Jian-Hua Wang Zhi-Ping Yan Ping Wang, Department of Radiology, Affiliated Zhongshan Hospital, Fudan University, Shanghai 200032, China | 2003 | World Journal of Gastroenterology2003，9，10： | 22 |
| 5 | Can transgenic rice cause ecological risks through transgene escape?显示文摘Alien transgene escape from genetically engineered rice to non-transgenic varieties or close wild relatives (including weedy rice) may lead to unpredictable ecological risks. However, for transgene escape to occur three conditions need to be met: (i) spatially, transgenic rice and its non-transgenic counterparts or wild relatives should have sympatric distributions; (ii) temporally, the flowering time of transgenic rice and the non-transgenic varieties or wild relatives should overlap; and (iii) biologically, transgenic rice and its wild relative species should have such a sufficiently close relationship that their interspecific hybrids can have normal generative reproduction. This paper presents research data on the geographic distribution, flowering habits, interspecific hybridization, and gene flow of cultivated rice (Oryza sativa) and its closely related wild relatives containing the AA genome. The objective is to estimate the possibility of transgene escape to non-transgenic rice varieties and wild relatives of rice, which may result in unpredictable ecological risks. | LU Baorong , SONG Zhiping and CHEN Jiakuan(Ministry of Education Key Laboratory for Biodiversity and Ecological Engineering, Institute of Biodiversity Science, Fudan University, Shanghai 200433, China) | 2003 | Progress in Natural Science:Materials International2003，13，1： | 21 |
| 6 | Changed clinical aspects of primary liver cancer in China during the past 30 years显示文摘BACKGROUND: Primary liver cancer (PLC) is one of the most frequently seen tumors in China. Thirty years ago, patients with PLC were often detected at relatively late stage, with a palpable mass or marked clinical symptoms and poor prognosis. In the past 30 years, the diagnosis and treatment of PLC have been greatly improved with better prognosis. METHODS: In order to study the changes of PLC during the 30 years, the clinical data of 3250 patients with PLC from 10 medical institutions of China were collected, ana- lyzed , and compared with those of 3254 PLC patients be- fore the 30 years. RESULTS: In the 3250 patients aged 1-80 years, with an average age of 49.1 years, the male to female ratio (2.3:1) was lower than that before the 30 years. 73.5% of the 3250 patients sought medical advice within 3 months after the onset of the disease in contrast to 63.8% before the 30 years. Compared with those patients before the 30 years the symptoms and signs were alleviated generally. The HBsAg positive rate was 81.0%, but the HCV-Ab positive rate was 13.2%. The AFP level in 75% of patients was elevated, but in the remaining 25% was normal. 1912 patients (58.8%) were confirmed pathologically. Among them 1755 patients (91.8%) had hepatocellular carcinoma. The overall resec- tion rate was 46.3%. Those who had early, middle, late stage carcinoma accounted for 29.9%, 51.5%, and 18.6%respectively in contrast to 0.4%, 47.0%, and 52.6% repor- ted before the 30 years. The 1-, 3-, 5-year survival rates of the patients were 66.1%, 39.7%, and 32.5% respectively, whereas 93.5%, 70.1%, and 59.1% for the early stage pa- tients, and 65.3%, 30.5%, and 23.5% for the middle stage patients. The half and 1-year survival rates of the late stage patients were 52.5%, and 14.7%, respectively. CONCLUSION: Comparison with the clinical data before and after the 30 years show that PLC can be diagnosed ear- ly. More PLC patients tend to undergo resection while re- ceiving a better conservative treatment, which ensures a prognosis. | Bing-Hui Yang, Jing-Lin Xia, Li-Wen Huang, Zhao-You Tang, Ming-Shan Chen, Jin-Qing Li, An-Min Liang, Qin-Guo Mo, Hui-Shan Lu, Chao-Liu Dai, Lu-Nan Yan, Zhi-Jian Yu, Rong-Sheng Rao, Le-Qun Li, Zhi-Xiong Su, Zhuang-Wei Fang Shanghai, China Liver Cancer Institute & Zhongshan Hospital, Fudan University, Shanghai 200032, China Tumor Hospital, Zhongshan University, Guangzhou 510000, China Tumor Hospital, Guangxi Medical Universi- ty, Nanning 530000, China Xiehe Hospital, Fujian Medical University, Fuzhou 350000, China Second Hos- pital, Chinese Medical University, Shenyang 110000, China Huaxi Hospital, Sichuan University, Chengdu 610041, China Hospital Affiliated to Nantong Medical University, Nantong 226000 , China Second Hospital, Jiangxi Medical University, Nanchang 330000 , China First Hospital Affiliated to Guangxi Medical University, Nanning 530000 , China People’s Hospital of Hainan Province, Haikou 570000, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 20 |
| 7 | Effects of hypoxia,hyperoxia on the regulation of expression and activity of matrix metalloproteinase-2 in hepatic stellate cells显示文摘AIM To study the effects of hypoxia, hyperoxia on the regulation of expression and activity of matrix metalloproteinase-2 (MMP-2) in hepatic stellate cells ( HSC).``METHODS The expressions of MMP-2, tissue inhibitor of mjatrix metalloproteinese-2 ( TIMP-2 ) and membrane type matrix metalloproteiness-l (MT1-MMP) in cultured rat HSC were detected by immunocytochemistry (ICC) and in situ hybridization (ISH). The contents of MMP-2 and TIMP-2 in culture supernatant were detected with ELISA and the activity of MMP-2 in supematant was revealed by zymography.``RESULTS In the situation of hypoxia for 12 h, the expression of MMP-2 protein wss enhenced (hypoxiagroup positive indexes: 5.7 ± 2.0, n = 10; control: 3.2 ±1 .0. n -- 7; P<0.05). while TIMP-2 protein wss decreased in HSC ( hypoxia group positive indexes: 2.5 ± 0.7, n =10: control: 3.6 ± 1.0, n = 7; P | Ping-Sheng Chen~(1,2) Wei-Rong Zhai~1 Xiao-Mei Zhou~3 Jin-Sheng Zhang~1 Yue-E Zhang~1 Yu-Qin Ling~1 Ying-Hong Gu~1 1 Department of Pathology,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China2 Ping-Sheng Chen now works in the Department of Pathology,School of Basic Medical Sciences the (former Nanjing Railway Medical College),Southeast University,Nanjing 210009,China3 Institute of Cancer Research,Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，5： | 18 |
| 8 | Percutaneous transsplenic embolization of esophageal and gastrio-fundal varices in 18 patients显示文摘AIM: Clinical application and potential complication of percutaneous transsplenic varices embolization (PTSVE) of esophageal or gastrio-fundal varices in patients with hepatocellular carcinoma (HCC) complicated with portal vein cancerous thrombosis (PVCT).METHODS: 18 patients with HCC complicated with PVCT and esophageal or gastrio-fundal varices who underwent PTSVE were collected. The rate of success, complication, mortality of the procedure and postoperative complication were recorded and analyzed.RESULTS: PTSVE were successfully performed in 16 of 18cases, and the rate of success was 89%. After therapy erythrocyte counts decreased in all of the natunts. 5 of patients needed blood transfusion, 2 patients requiredsurgical intervention because of and 11 patients with ascites were alleviated by diuresis. Among these 18patients, the procedure-related mortality was 11% (2/18),one died of acute hepatic failure on the forth day after procedure, another died of acute renal failure on the fifth day. The patients were follow up for 112 mon exceptone. 13of them died of their tumors but none of them experienced variceal bleeding.CONCLUSION: PTSVE is a relatively safe and effective method to treat esophageal or gastrio-fundal varices in HCCpatients with PVCT when percutaneous transhepatic varices embolization (PTHVE) of varices is impossible. | Gao-Quan Gong Xiao-Lin Wang Jian-Hua Wang Zhi-Ping Yan Jie-Min Cheng Sheng Qian Yi Chen Department of Radiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，6： | 14 |
| 9 | Application of needle-knife in difficult biliary cannulation for endoscopic retrograde cholangiopancreatography显示文摘BACKGROUND: Getting directly into the common bile duct (CBD) is the most important step for successful therapeutic biliary endoscopy. In 5%-10% of cases, the CBD remains inaccessible, necessitating pre-cut papillotomy or fistulotomy with a needle-knife. The aim of this study was to assess the value of early application of the needle-knife in difficult biliary cannulation for endoscopic retrograde cholangiopancreatography (ERCP). METHODS: Patients with failed biliary cannulation after 10 minutes or guide wire entering the pancreatic tube 3 times were randomly divided into group of needle-knife cut and group of persistent cannulation by standard techniques. The cannulation times, success rates and complication rates were compared between the two groups. RESULTS: A total of 948 therapeutic biliary ERCP procedures were performed between October 2004 and February 2006. Of 91 patients with difficult biliary cannulation, 43 patients underwent needle-knife cut: the cannulation success rate was 90.7%, the mean cannulation time was 5.6 minutes, and the complication rate was 9.3%. The other 48 patients underwent persistent cannulation by standard techniques: the cannulation success rate was 75%, the mean cannulation time was 10.2 minutes, and the complication rate was 14.6%. Significant differences were observed in cannulation success rate and cannulation time but in complication rate between the two groups.CONCLUSION: The early application of the needle-knife in difficult biliary cannulation is time-saving, safe and effective, with no increase in complication rate. | Ping-Hong Zhou, Li-Qing Yao, Mei-Dong Xu, Yun-Shi Zhong, Wei-Dong Gao, Guo-Jie He, Yi-Qun Zhang, Wei-Feng Chen and Xin-Yu Qin Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 14 |
| 10 | Housing Wealth, Financial Wealth and Consumption in China显示文摘纸在城市的中国在财产财富和家庭消费的趋势运动调查在变化之间的关系。用向量错误修正 cointegration 模型,我们证明在城市的中国在家庭消费,可处理的收入,金融财富和住房财富之间有一种唯一的长期间 cointegrating 关系。当 cointegrated 系统被外部震动扰乱时,我们发现住房财富是恢复长期间平衡关系的唯一的因素。另外,我们的永久临时的变化分解分析都显示那在消费的运动的变化是永久的,支持消费行为的古典随机的散步假设。然而,在住房财富的短期的运动的变化的一个大比例被发现临时。 | Jie Chen Feng Guo Aiyong Zhu Associate Professor,School of Management,Fudan University,Shanghai,China. Senior Research Economist and Economics Lecturer,Haile/US Bank College of Business,Northern Kentucky University,Highland Heights,USA. Master Student,School of Economics,Fudan University,Shanghai,China. | 2009 | China & World Economy2009，17，3： | 10 |
| 11 | Methodological study on real-time three-dimensional echo-cardiography and its application in the diagnosis of complex congenital heart disease显示文摘背景实时三维的回响心动描记法(RT-3DE ) 在过去几年期间使心脏的成像的改进革命化。然而,到目前为止为 RT-3DE 没有标准考试方法。这研究试图建立 RT-3DE 的诊断方法并且在复杂的先天的心疾病(CHD ) 的诊断评估它的申请。有复杂 CHD 的五十个病人被 RT-3DE 与实时 3DE 和 FullVolume 的模式检查的方法。一系列新奇容量的看法与凡·普拉格结合了顺序的部分途径被介绍揭示心的病理学的形态学,它与二维的回响心动描记法(2DE ) 的调查结果相比, angiography 和心脏的外科。在 50patients 的结果,完整的体积的 190 图象获得在几声学的窗口 includingsubcostal 被执行,顶端并且同等不连胸骨的区域。在他们之中,(179/190 )94.2% 图象获得是成功的。最部分的容量的看法能清楚地在 92.6% 成功的图象获得被显示。然而,部分容量的看法不能清楚地在 7.4% 被显示,它主要由于考试地点,不适当的 instrumentmulti 参数背景和在完整的 Volumeacquisitions 捕获的整个心的不够的信息的差的观点条件。作为与外科的调查结果和 angiography 相比, RT-3DE 与单个中庭与大动脉和其它的改正的调换包括 1 在 2 种情况中做了修正到 diagnoses 并且僧帽形劈开。2DE 开始为这 2 个病人做的 diagnoses 是有大动脉和 completeatrio 室的氏族的缺点的调换的两倍插头权利室。结论 RT-3DE 能清楚地由容量的看法通过提供更空间的增进知识的心血管的结构与顺序的部分途径相结合的一系列小说显示复杂 CHD 的病理学的形态学,它为 RT-3DE 诊断提供一个实际方法。 | CHEN Guo-zhen, HUANG Guo-ying, LIANG Xue-cun, MA Xiao-jing, CHEN Wei-da, TAO Zi-yu and LIN Qi-shan Pediatric Heart Center, Children’s Hospital of Fudan University Department of Pediatrics, Shanghai Medical College, Shanghai 200032, China | 2006 | Chinese Medical Journal2006，，14： | 9 |
| 12 | Teracluster LSSC-II--Its designing principles and applications in large scale numerical simulations显示文摘The teracluster LSSC-II installed at the State Key Laboratory of Scientific and Engineering Computing, Chinese Academy of Sciences is one of the most powerful PC clusters in China. It has a peek performance of 2Tflops. With a Linpack performance of 1.04Tflops, it is ranked at the 43rd place in the 20th TOP500 List (November 2002), 51st place in the 21st TOP500 List (June 2003), and the 82nd place in the 22nd TOP500 List (November 2003) with a new Linpack performance of 1.3Tflops. In this paper, we present some design principles of this cluster, as well as its applications in some large-scale numerical simulations. | ZHANG Linbo, CHEN Shiyi, LI Xinliang, CAO Jianwen, ZHANG Wensheng & GONG XingaoState Key Laboratory of Scientific and Engineering Computing, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Department of Mechanical Engineering, The Johns Hopkins University and Center for Computational Science and Engineering, Peking University, Beijing 100875, China Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China Parallel Computing Laboratory, Institute of Software, Chinese Academy of Sciences, Beijing 100080, China Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Surface Physics Laboratory (National Key Laboratory), Fudan University, Shanghai 200433 Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, China | 2004 | Science China Mathematics2004，47，z1： | 8 |
| 13 | Riemann boundary value problems and reflection of shock for the Chaplygin gas显示文摘In this paper,we study two-dimensional Riemann boundary value problems of Euler system for the isentropic and irrotational Chaplygin gas with initial data being two constant states given in two sectors respectively,where one sector is a quadrant and the other one has an acute vertex angle.We prove that the Riemann boundary value problem admits a global self-similar solution,if either the initial states are close,or the smaller sector is also near a quadrant.Our result can be applied to solving the problem of shock reflection by a ramp. | CHEN ShuXing 1,& QU AiFang 2 1 School of Mathematical Sciences,Fudan University,Shanghai 200433,China 2 Wuhan Institute of Physics and Mathematics,Chinese Academy of Sciences,Wuhan 430071,China | 2012 | Science China Mathematics2012，55，4： | 6 |
| 14 | Correlation of glycosyltransferases mRNA expression in extrahepatic bile duct carcinoma with clinical pathological characteristics显示文摘BACKGROUND: The incidence of extrahepatic bile duct carcinoma (EBDC) has been increasing, especially in aged people, but the glycobiology of the tumor is not elucida- ted. In this study we investigated the expressions of three glycosyltransferases in 35 patients with EBDC and 35 pa- tients with benign biliary duct disease (BBDD) as well as their clinicopathological significance. METHOD: The patients were divided into several sub- groups by tumor differentiation, TNM stage, and invasion by the standards recommended by UICC. Tumor samples were immediately frozen in liquid nitrogen after resection, followed by mRNA determination of enzymes in the tissue using a mRNA selective reverse trancriptase-polymerase chain reaction kit. The mRNA levels of different groups were semi-quantitatively compared. RESULTS: The mRNA levels of N-acetylglucosaminyltrans- ferase V (GnT-V) and a subtype of α2,3 sialyltransferases for N-glycans, ST3Gal- were elevated 7.75 and 5.39 times in EBDC as compared with BBDD, respectively, and they were correlated to several clinicopathological factors including tumor advancement, differentiation, metastasis, and invasiveness. The mRNA expression of another sialyl- transferase, ST6Gal- , was also 0.63-fold higher in EBDC than in BBDD, but not involved in the clinicopathological characteristics. CONCLUSION: The elevated expression of these three gly- cosyltransferases can be considered as an important molecu- lar event in the occurrence and progression of EBDC. | Xiao-Ling Jin, Shu-Sen Zheng, Bing-Sheng Wang and Hui-Li Chen Nanjing, China Department of General Surgery, Nanjing First Hospi- tal Affiliated to Nanjing Medical University, Nanjing 210006, China Department of Hepatobiliary Surgery, First Affiliated Hospital, Zhe- jiang University School of Medicine, Hangzhou 310003, China Department of General Surgery, Zhongshan Hospital, Fudan Universi- ty, Shanghai 200032 , China and Key Laboratory of Glycocon- jugate Research, Ministry of Health, Department of Biochemistry, Fudan University School of Medicine, Shanghai 200032, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 6 |
| 15 | Hepatocellular carcinoma associated with tumor thrombosis in the portal vein: the effects of different treatments显示文摘OBJECTIVES: To compare the effects of different treatments for hepatocellular carcinoma (HCC) withtumor thrombosis in the portal vein (TTPV) and evaluate the factors influencing the prognosis.METHODS: One hundred and thirty-eight patients with HCC associated with TTPV, whose liver functionwas compensative and the tumor with TTPV can probably be resected together, were divided into fourgroups: conservative treatment group (n=14); chemotherapy group (n=19); surgical resection group(n=19); and surgical resection with postoperative chemotherapy group (n=64).RESULTS: The median survivals of the four groups were 3.5, 7.1, 10.1 and 13.4 months, respectively.The 0.5-, 1-, 2-, and 3-year cumulative survival rates of the surgical resection with postoperativechemotherapy group were 53.7%, 37.6%, 30.7% and 14.0% respectively, which were significantlyhigher than those of the other three groups (P<0.05). Both univariate and multivariate analysis revealedthat postoperative chemotherapeutic course was the most important factor affecting the surgical results.CONCLUSIONS: If patients’ liver fimction is compensative and tumors with TTPV can be removedtogether, exploration should be done. Surgical resection combined with postoperative chemotherapy canachieve the best results. More chemotherapeutic courses after surgical resection can be prescribed if thepatients have good hepatic functional reserve. | Jia Fan Zhi-Quan Wu Jian Zhou Shuang-Jian Qiu Ying-Hong Shi Rong-Xin Chen Zhao-You Tang the Liver Cancer Institute, Zhongshan Hospital, Fudan University Shanghai Medical School, Shanghai 200032, China | 2003 | Hepatobiliary & Pancreatic Diseases International2003，2，4： | 6 |
| 16 | Biodistribution of fullerene derivative C_(60)(OH)_x(O)_y显示文摘The biological behavior of fullerene derivatives shows their considerable potential application in medicine field. To understand the biodistribution of C60 derivatives as drugs or drug carriers, a simple water-soluble derivative C60(OH)x(O)y was labeled with 99mTc. A r-counter and a single photo emission computed tomography (SPECT) were used to assess the biodistribution and metabolism of the labeled compound in mice and rabbits, respectively. The results showed that the compound could be absorbed rapidly by tissues, especially by coronal bone, breastbone, backbone, extremity honeycomb, liver and spleen. The clearance was slow from all tissues except for brain. The compound might be excreted through urine and enteron. The biodistribution shows some difference from that of Yamago et al. In this note, we discuss the possible reason leading to the difference. Further study is needed to find out to what extent the C60 itself determines the biodistribution of derivatives. | LI Qingnuan, XIU Yan, ZHANG Xiaodong, LIU Ruili, DU Qianqian, SUN Xiaoguang, CHEN Shaoliang & LI Wenxin1. Shanghai Institute of Nuclear Research, Chinese Academy of Sciences, Shanghai 201800, China 2. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China | 2001 | Chinese Science Bulletin2001，46，19： | 5 |
| 17 | Two Novel Myrinsol Diterpenes from Euphorbia prolifera显示文摘Two novel diterpenes, Euphorprolitherin A (1) and Euphorprolitherin B (2), were isolated from the roots of Euphorbia prolifera. Their structures were elucidated on the basis of spectroscopic methods. | Wan Jin ZHANG, Dao Feng CHEN*, Ai Jun HOU Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032 | 2002 | Chinese Chemical Letters2002，13，8： | 5 |
| 18 | MR dynamic Gadolinium-enhanced fast multiplanar spoiled gradient-echo and spin-echo T1-weighted fat-suppressed techniques in diagnosis of pancreatic carcinoma显示文摘Objective: To evaluate the value of MR dynamicGadolinium-enhanced fast multiplanar spoiled gradi-ent-echo (FMPSPGR) and spin-echo (SE) T1-weighted fat-suppressed techniques in the diagnosis ofpancreatic carcinoma.Methods: Eighteen cases of pancreatic carcinoma veri-fied by surgical and pathologic results were examinedby MR, and the MR sequences included SE T1WI,FSE T2WI, SE T1-weighted fat-suppressed and dy-namic Gadolinium-enhanced FMPSPGR.Results: Of 18 pancreatic carcinomas, 10, 6, and 2tumors showed respectively hypo-intensity, iso-inten-sity and hyper-intensity on SE T1WI, meanwhile, 8,6, and 4 tumors displayed hyper-intensity, iso-inten-sity and hypo-intensity on FSE T2WI in comparisonwith the normal pancreatic tissue. All of the tumorsshowed hypo-intensity on SE T1-weighted fat-sup-pressed and also obvious non-enhancement or slightenhancement on MR dynamic Gadolinium-enhancedFMPSPGR images during the arterial dominantphase scanning.Conclusion: SE T1-weighted fat-suppressed and MRdynamic Gadolinium-enhanced FMPSPGR sequencescould evidently improve the sensitivity and specificityin the diagnosis of pancreatic carcinoma. | Meng-Su Zeng Fu-Hua Yan Kang-Rong Zhou Zhu-Wan Chen Ji-Zhang Sun Cai-Zhong Chen Wei-Bing Shi From the Dapartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，2： | 4 |
| 19 | The fundamental solution of the Keldysh typeoperator显示文摘In this paper we discuss the fundamental solution of the Keldysh type operator Lαu■ 2u x2 + y 2yu y2 + α u y1 , which is a basic mixed type operator different from the Tricomi operator. The fundamental solution of the Keldysh type operator with α>-1/2 is obtained. It is shown that the fundamental solution for such an operator generally has stronger singularity than that for the Tricomi operator. Particularly, the fundamental solution of the Keldysh type operator with α<1/2 has to be defined by using the finite part of divergent integrals in the theory of distributions. | CHEN ShuXing School of Mathematical Sciences, Fudan University, Shanghai 200433, China | 2009 | Science China Mathematics2009，52，9： | 3 |
| 20 | Speciation of the elements and compositions on the surfaces of dust storm particles:The evidence for the coupling of iron with sulfur in aerosol during the long-range transport显示文摘The speciation of the elements on the surface of the particles collected during dust storm and non-dust storm in Beijing and Inner Mongolia was studied by XPS. The ma- jor species of iron on the surface were oxides, sulfate, silicate, FeOOH and minor part sorbed on SiO2/Al2O3. Sulfate is the dominant species of sulfur on the surface. SiO2 and Al2O3 are the main components of Si and Al on the surface respectively. One of the most important findings was that the Fe(II) (FeS and FeSO4) produced could account for up to 44.3% and 45.6% of the total Fe on the surface in the aerosol sample collected at that night and next day of the “peak” time of the dust storm occurring on March 20, 2002, while Fe2(SO4)3, one of the Fe(III) species on the surface decreased from 67.1% to 49.5% and 48.0% respectively. Both S and Fe en- riched on the surface of aerosol particles. Fe(II) accounted for 1.3%?5.3% of total Fe in bulk aerosol samples during dust storm. These results provided strong evidence to sup- port the hypothesis of the coupling between iron and sulfur in aerosols during the long-range transport, which would have important impact on the global biogeochemical cycle. | ZHANG Xingying1,2, ZHUANG Guoshun1,2,3, CHEN Jianmin2 & XUE Huaxin2 1. Center for Atmospheric Environment Study, Department of Chemistry, Beijing Normal University, Beijing 100875, China 2. Center for Atmospheric Chemistry Study, Department of Environ- mental Science and Engineering, Fudan University, Shanghai 200433, China 3. LAPC/NZC, Institute of Atmospheric Physics, NZC/LAPC, Chinese Academy of Sciences, Beijing 100029, China | 2005 | Chinese Science Bulletin2005，50，8： | 3 |
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