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| 1 | Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection显示文摘AIM: To investigate the relationship between low molecular polypeptide-7 (LMP-7) gene polymorphism and response to interferon (IFN) therapy in chronic hepatitis C virus (HCV) patients. METHODS: LMP-7 polymorphism at codon 49 with nucleotide substitution from A to C was amplified in 104 chronic HCV patients of genotype 4. The amplicons were digested with restriction endonuclease Bsm I and the produced restriction fragment length polymorphism was analyzed. Patients received IFN + regional blood volume therapy for 48 wk and the frequency of thissingle nucleotide polymorphism (SNP) was statistically correlated with treatment response. The exclusion criteria for these patients were stated by the national health program for treating viral hepatitis. Main exclusion criteria included co-infection with hepatitis B virus or schistosomiasis, thyroid dysfunction, uncontrolled diabetes mellitus, history of long term drug or alcohol intake and autoimmune hepatitis. Multivariate analyses were done to correlate LMP-7 SNP plus several factors such as age, gender, weight, serum alpha-fetoprotein (AFP) and alanine aminotransferase levels, liver activity, fibrosis score and viral load with response to therapy. RESULTS: The data presented in this study clearly demonstrated statistically significant differences between sustained virological response (SVR) (defined as the absence of HCV RNA levels in the patient's sera at least 6 mo after discontinuation of treatment) and non-response (NR) (where HCV RNA levels in the patient's sera never become undetectable for 6 mo during or after treatment). Variables were described as odds ratio with 95%CI. The data were considered significant if P values were ≤ 0.05; highly significant if P < 0.01 and very highly significant if P < 0.001. Current data showed that 91.7% of patients carrying LMP-7 C/C allele were associated with SVR, while the other two genotypes C/A and A/A were associated with NR patients, 83.3% and 64.3% respectively, showing that genotype CC was strongly associated with response to interferon (95%CI: 12.0719-134.6572, P = 0.0001). The majority of parameters recorded in SVR and NR patients included higher values of mean age (P = 0.004), alanine aminotransferase (P = 0.001), AFP (P = 0.001), body weight (P = 0.025), viral load (P = 0.025), higher fibrosis and histological activity index indices among NR vs SVR patients. Also, the multivariate statistical analysis of the different factors of fibro-sis score, liver activity grade, genotypes and alleles of LMP-7 gene polymorphism in responders and NRs of HCV patients in this study showed that HCV patients with A allele had a very highly significant association with the NRs, high fibrosis and higher liver activity, while the C allele had a very highly significant association with the responders, low fibrosis and lower liver activity (95%CI: 3.5800-13.2519, P = 0.0001).CONCLUSION: LMP-7 SNP is a candidate gene that should be considered when designing a mathematical model for predicting response to therapy and disease progression in HCV patients. | Moataza H Omran Basma E Fotouh Samar S Youssef Noha E Ibrahim Wael Nabil EL-Sayed M Mahdy Wafaa G Shosha Mostafa K El-Awady | 2013 | World Journal of Hepatology2013，5，3： | 4 |
| 2 | Traveling- wave -based fault- location scheme for multiend- aged underground cable system显示文摘 | GILANY M G IBRAHIM D K SAYED E | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 3 | A comparative analysis of patients with early-onset vs late-onset nosocomial pneumonia in the ICU setting显示文摘 | IBRAHIM E H WARD S SHERMAN G | 2000 | Chest2000，117，5： | 1 |
| 4 | Metal-organic framework materials with ultrahigh surface areas: is the sky the limit?显示文摘 | Farha Omar K Eryazici Ibrahim Jeong Nak Cheon Hauser Brad G Wilmer Christopher E Sarjeant Amy A Snurr Randall Q Nguyen SonBinh T Ozgox Yazaythn A Hupp Joseph T | 2012 | Journal of the American Chemical Society2012，134，15： | 1 |
| 5 | Pseudoangiomatous hyper~plasia of mammary stroma:some observations regarding its clinicopathologic spectrum显示文摘 | SCIOTTO C G WEIDNER N | 1989 | Cancer1989，63，： | 1 |
| 6 | Pseudoangiomatous hy- perplasia of mammary stroma: some observations regarding its clinicopathologic spectrum显示文摘 | Ibrahim R E Sciotto C G Weidner N | 1989 | Cancer1989，63，： | 1 |
| 7 | Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver ( APASL ) 显示文摘 | Shiha G Sarin S K Ibrahim A E | 2009 | Hepatol Int2009，3，2： | 1 |
| 8 | Thiolcontaining compounds as controlling agents of enzymatic browningin some apple products显示文摘 | Eissa H A Fadel H H M Ibrahim G E | 2006 | Food Res Int2006，39，8： | 1 |
| 9 | A comparative analysis of transcript abundance using SAGE and Affymetrix arrays显示文摘 | IBRAHIM A F M HEDLEY P E CARDLE L KRUGER W MARSHALL D F MUEHLBAUER G J WAUGH R | 2005 | Functional & Integrative Genomics2005，5，3： | 1 |
| 10 | Multicenter, randomized, double-blind, placebo-controlled study on the effect of oral tolvaptan on left ventricular dilation and function in patients with heart failure and systolic dysfunction显示文摘 | Udelson J E McGrew F A Flores E Ibrahim H Katz S Koshkarian G | 2007 | J Am Coll Cardiol2007，49，： | 1 |
| 11 | Develop-ment of carbon-Low alloy steel grades for low temperature ap-plications显示文摘 | TAHER E B MOHAMMED G IBRAHIM M | 2011 | Materials Science and Engineering A2011，528，18： | 1 |
| 12 | Experience with a clinical guideline for the treatment of ventilator-associated pneumonia显示文摘 | Ibrahim E H Ward S Sherman G | 2001 | Crit Care Med2001，29，6： | 1 |
| 13 | Use of the intraosseous screw for unilateral upper molar distalization and found well balanced occlusion 显示文摘 | Ibrahim E G Ali lhya K Tamer B | 2006 | Head Face Med2006，2，： | 1 |
| 14 | Development of carbon-low alloy steel grades for low tcrnpcraturc applications显示文摘 | TAHER E B MOHAMMED G IBRAHIM M ctal | 2011 | Materials Science and Engineering: A2011，528，18： | 1 |
| 15 | Chemical Composition and the Insecticidal Activity of Certain Plants Applied as Powders and Essential Oils against Two Stored-products Coleopteran Beetles显示文摘 | NENAAH G E IBRAHIM S | 2011 | Journal of Pest Science2011，84，3： | 1 |
| 16 | Using nonwoven hollow fibers to improve cars interior acoustic properties显示文摘 | ABDELFArl3'AH A M IBRAHIM G E MAHMOUD E R | 2011 | Life Science Journal2011，，： | 1 |
| 17 | Thiol containing compounds as controlling agents of enzymatic browning in some apple products显示文摘 | Eissa H A Fadel H H M Ibrahim G E | 2006 | Food Res Int2006，39，8： | 1 |
| 18 | Diamond semi conductor technology for RF device applications 显示文摘 | YASUR G ONUR E IBRAHIM T | 2005 | Solid State Electronics2005，49，7： | 1 |
| 19 | Characterization of ureteral stents by dual-energy computed tomography: Clinical implications显示文摘Dual-energy computed-tomography(DECT) has been suggested as the method of choice for imaging urinary calculi due to the modality's high sensitivity for detect-ing stones and its capability of accurately differentiat-ing between uric-acid(UA) and non-UA(predominantly calcium) stones. The clinical significance of the latter feature relates to the differences in management of UA vs non-UA calculi. Like calculi, ureteral stents are assigned color by the dual-energy post-processing algorithm, which may lead to improved or worsened stone visualization based on the resulting stent/stone contrast. Herein we depict the case of a nephrolithiasis patient with bilateral stents, each with different color, clearly displaying the effect of stent color on stone vi-sualization. Further, three-dimensional reconstruction of the DECT images illustrates advantages of this enhancement compared to conventional two-dimensional computed tomography. The resulting stent/stone contrast produces an unanticipated potential advantage of DECT in patients with urolithiasis and stents and may promote improved management decision-making. | El-Sayed H Ibrahim William E Haley Maria A Jepperson Michael J Wehle Joseph G Cernigliaro | 2014 | World Journal of Radiology2014，6，8： | 1 |
| 20 | Pseudoangiomatous hyperplasia of mammary stroma:some observations regarding its clinicopathologic spectrum 显示文摘 | Ibrahim R E Sciotto C G Weidner N | 1989 | Cancer1989，63，： | 1 |
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