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| 1 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 2 | Study of Temperature Distribution Along an Artificially Polluted Insulator String显示文摘Insulator becomes wet partially or completely, and the pollution layer on it becomes conductive, when collecting pollutants for an extended period during dew, light rain, mist, fog or snow melting. Heavy rain is a complicated factor that it may wash away the pollution layer without initiating other stages of breakdown or it may bridge the gaps between sheds to promote flashover.The insulator with a conducting pollution layer being energized, can cause a surface leakage current to flow (also temperature-rise). As the surface conductivity is non-uniform, the conducting pollution layer becomes broken by dry bands (at spots of high current density), interrupting the flow of leakage current. Voltage across insulator gets concentrated across dry bands, and causes high electric stress and breakdown (dry band arcing). If the resistance of the insulator surface is sufficiently low, the dry band arcs can be propagated to bridge the terminals causing flashover.The present paper concerns the evaluation of the temperature distribution along the surface of an energized artificially polluted insulator string. | B Subba Reddy G R Nagabhushana | 2003 | Plasma Science and Technology2003，5，2： | 24 |
| 3 | Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection显示文摘 | Arie Regev Mariana Berho Lennox J Jeffers Clara Milikowski Enrique G Molina Nikolaos T Pyrsopoulos Zheng-Zhou Feng K.Rajender Reddy Eugene R Schiff | 2002 | The American Journal of Gastroenterology2002，，10： | 7 |
| 4 | Large cystic lesions of the liver in adults: a 15-year experience in a tertiary center 1 1 No competing interests declared.显示文摘 | Arie Regev K.Rajender Reddy Mariana Berho Dan Sleeman Joe U Levi Alan S Livingstone David Levi Unzila Ali Enrique G Molina Eugene R Schiff | 2001 | Journal of the American College of Surgeons2001，，1： | 2 |
| 5 | Cytokinin signaling regulates pavement cell morphogenesis in Arabidopsis显示文摘难题有交错的脑叶的塑造片的 Arabidopsis 叶人行道房间(PC ) 并且缩排是一个好模型系统调查在纸巾以内协调房间极性和形状形成的机制。植物生长素被显示了 GTPase 依赖的发信号由激活 ROP 协调 interdigitation 小径。识别另外的部件或机制,我们与反常 PC 形态发生为异种屏蔽了并且发现细胞激动素发信号调整 PC interdigitation 模式。在细胞激动素累积的减小和在细胞激动素发信号的缺点(例如在 ARR7-over-expressing 线, ahk3cre1 细胞激动素受体异种,和 ahp12345 细胞激动素表明异种) 提高的 PC interdigitation,而细胞激动素的生产过剩和细胞激动素在一根 ARR20 在表示上线发信号的在激活上在整个子叶推迟了或废除 PC interdigitation。基因、生物化学的分析建议表明 ROP 在上游的行为压制交错的模式的形成的那细胞激动素。我们的结果提供控制 PC 形状的小径的新奇机械学的理解并且揭开为细胞激动素在房间形态发生发信号的一个新角色。 | Hongjiang Li Tongda Xu Deshu Lin Mingzhang Wen M ingtang Xie Jērōme Duclercq Agnieszka Bielach Jungmook Kim G Venugopala Reddy Jianru Zuo Eva Benková Jiгi Friml Hongwei Guoz Zhenbiao Yang | 2013 | Cell Research2013，23，2： | 2 |
| 6 | Finite element based evaluation of stress intensity factors for interactive semi-elliptic surface cracks 显示文摘 | Sethuraman R Reddy G S S Ilango I T | 2003 | International Journal of Pressure Vessels and Piping2003，80，2： | 1 |
| 7 | Effect of fodder based complete diets on the rumen fermentation pattern in crossbred bulls显示文摘 | Reddy N M Reddy G V N Reddy M R | 1993 | Indian Journal of Animal Sciences1993，10，1： | 1 |
| 8 | Differences in vitro pollen germination and pollen tube growth of cotton cuhivars in response to high temperature显示文摘 | Kakani V G Reddy K R Konti S | 2005 | Annals of Botany2005，96，6： | 1 |
| 9 | Field crop responsesto ultraviolet-B radiation显示文摘 | Kakani V G Reddy K R Zhao D | 2003 | Agri For Meteor2003，120，： | 1 |
| 10 | Effect of phosphorus nutrition on growth and physiology of cotton under ambient and elevated carbon dioxide显示文摘 | Singh S K Badgujar G B Reddy V R | 2013 | Journal of Agronogy and Crop Science2013，199，6： | 1 |
| 11 | 4 - Chlorophenyl and Acrylate and Glyeidyl Methacrylate Copolymer: Synthesis, Characterization, Reactivity Ratios and Application显示文摘 | P G Vijayaraghavan B S R Reddy | 1999 | JMSPUPE APPL CHEM1999，36，9： | 1 |
| 12 | In vitro somatic embryogenesis and regeneration of somatic embryos from pigmented callus of Kappaphycus alvarezii ( Doty ) Doty ( Rhodophyta, Gigartinales) 显示文摘 | Reddy C R K Kumar G Siddhanta A K | 2003 | J Appl Phycol2003，39，： | 1 |
| 13 | Porous structured vanadium oxide electrode material for electrochemical capacitors显示文摘 | Reddy R N Reddy R G | 2006 | Journal of Power Sources2006，156，2： | 1 |
| 14 | Synthesis and electrochemical characterization of amorphous MnO2 electrochemical capacitor electrode material显示文摘 | Reddy R N Reddy R G | 2004 | J Power Sources2004，132，1： | 1 |
| 15 | 显示文摘 | Reddy N K Reddy K T R Fisher G | 1999 | J Phys D:Appl Phys1999，32，： | 1 |
| 16 | Sol-gel MnO2 as an electrode material for electrochemical capacitors显示文摘 | Reddy R N Reddy R G | 2003 | Journal of Power Sources2003，124，1： | 1 |
| 17 | Recycling of a- luminum metal matrix composite using ionic liquids: Effect of process variables on current efficiency and de- posit characteristics显示文摘 | Kamavaram V Mantha D Reddy R G | 2005 | Electrochimica Acta2005，50，1617： | 1 |
| 18 | Electrochemical production of Ti- A1 alloys using TiC14-A1C13-1 -butyl-3-methyl imidazolium chloride (BmimC1) electrolytes 显示文摘 | Pradhan D Reddy R G | 2009 | Electrochimica Acta2009，54，： | 1 |
| 19 | Materials and design development for bipolar/end plates in fuel cells显示文摘 | KUMAR A REDDY R G | 2004 | Journal of Power Sources2004，129，： | 1 |
| 20 | Detection of endogenous malondialdehyde-deoxyguanosine adducts in human live 显示文摘 | Chaudhary A K Nokubo M Reddy G R | 1994 | Science1994，265，5178： | 1 |
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