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| 1 | Role of inflammatory response in liver diseases: Therapeutic strategies显示文摘Inflammation and tumorigenesis are tightly linked pathways impacting cancer development. Inflammasomes are key signalling platforms that detect pathogenic microorganisms, including hepatitis C virus(HCV) infection, and sterile stressors(oxidative stress, insulin resistance, lipotoxicity) able to activate pro-inflammatory cytokines interleukin-1β and IL-18. Most of the inflammasome complexes that have been described to date contain a NOD-like receptor sensor molecule. Redox state and autophagy can regulate inflammasome complex and, depending on the conditions, can be either pro-or antiapoptotic. Acute and chronic liver diseases are cytokinedriven diseases as several proinflammatory cytokines(IL-1α, IL-1β, tumor necrosis factor-alpha, and IL-6) are critically involved in inflammation, steatosis, fibrosis, and cancer development. NLRP3 inflammasome gain of function aggravates liver disease, resulting in severe liver fibrosis and highlighting this pathway in the pathogenesis of non-alcoholic fatty liver disease. On the other hand, HCV infection is the primary catalyst for progressive liver disease and development of liver cancer. It is well established that HCV-induced IL-1β production by hepatic macrophages plays a critical and central process that promotes liver inflammation and disease. In this review, we aim to clarify the role of the inflammasome in the aggravation of liver disease, and how selective blockade of this main pathway may be a useful strategy to delay fibrosis progression in liver diseases. | José A Del Campo Paloma Gallego Lourdes Grande | 2018 | World Journal of Hepatology2018，10，1： | 25 |
| 2 | Management of primary achalasia: The role of endoscopy显示文摘Achalasia is an oesophageal motor disorder which leads to the functional obstruction of the lower oesophageal sphincter(LES) and is currently incurable. The main objective of all existing therapies is to achieve a reduction in the obstruction of the distal oesophagus in order to improve oesophageal transit, relieve the symptomatology, and prevent long-term complications. The most common treatments used are pneumatic dilation(PD) and laparoscopic Heller myotomy, which involves partial fundoplication with comparable shortterm success rates. The most economic non-surgical therapy is PD, with botulinum toxin injections reserved for patients with a higher surgical risk for whom the former treatment option is unsuitable. A new technology is peroral endoscopic myotomy, postulated as a possible non-invasive alternative to surgical myotomy. Other endoluminal treatments subject to research more recently include injecting ethanolamine into the LES and using a temporary self-expanding metallic stent. At present, there is not enough evidence permitting a routine recommendation of any of these three novel methods. Patients must undergo follow-up after treatment to guarantee that their symptoms are under control and to prevent complications. Most experts are in favour of some form of endoscopic follow-up, however no established guidelines exist in this respect. The prognosis for patients with achalasia is good, although a recurrence after treatment using any method requires new treatment. | Marisol Luján-Sanchis Patricia Suárez-Callol Ana Monzá-Gallego Inmaculada Bort-Pérez Lydia Plana-Campos Luis Ferrer-Barceló Laura Sanchis-Artero María Llinares-Lloret Juan Antonio Tuset-Ruiz Javier Sempere-Garcia-Argüelles Pilar Canelles-Gamir Enrique Medina-Chuliá | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 5 |
| 3 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 4 | Accuracy of Magnetic Resonance Enterography in Assessing Response to Therapy and Mucosal Healing in Patients With Crohn’s Disease显示文摘 | Ingrid Ordás Jordi Rimola Sonia Rodríguez José M. Paredes María J. Martínez-Pérez Esther Blanc Juan A. Arévalo Marta Aduna Montserrat Andreu Alexander Radosevic Anna M. Ramírez-Morros Susana Pinó Marta Gallego Aranzazu Jauregui-Amezaga Elena Ricart Julián | 2013 | Gastroenterology2013，，： | 3 |
| 5 | syndecan-1和-2表达形式的变化可以预测前列腺癌生化复发显示文摘前列腺癌的临床特点不能准确确定患者是否会发生生化复发,因而不适合作为预后和复发的指标。需要新的分子标记物对患者进行适当的术前风险分层。本研究旨在评估syndecan-1和-2的表达改变是否可以预测临床局限性前列腺癌患者行前列腺根治术后的生化复发。取60份局限性前列腺癌患者的石蜡包埋组织标本,采用免疫组化染色检测syndecan-1和-2的表达。取10份良性前列腺增生患者的样本作为非恶性对照。利用半定量分析,对其进行染色评估。为探讨预后效果,用Kaplan—Meier生存曲线进行分析,并进行log—rank检验。在良性前列腺样本中,syndecan-1在基底层上皮细胞中有表达,在上皮分泌细胞的基侧膜上也有表达;syndecan-2则主要但挞底层上皮细胞中表达。前列腺癌样本中,两种syndecan的表达模式都转变成定位在颗粒状细胞质上。生存分析显示,在游离前列腺特异性抗原(fPSA)复发存活曲线中,正常和改变的syndecan-1和-2的表达存在显著差异(P〈0.05)。这些数据表明,syndecan—1和-2可以作为临床局灶性前列腺癌患者预后的标记物,从而改进前列腺特异性抗原(PSA)评估复发风险,增加风险分层。 | Rodrigo Ledezma Federico Cifuentes Ivan Gallegos Juan Fulla Enrique Ossandon Enrique A Castellon Hector R Contreras | 2011 | Asian Journal of Andrology2011，13，3： | 2 |
| 6 | Transmission system expansion planning by an extended genetic algorithm显示文摘 | Gallego R A Monticelli A Romero R | 1998 | IEE Proceedings-Generation Transmission and Distribution1998，145，3： | 2 |
| 7 | The role of structure on the thermal properties of graphitic foams显示文摘 | KLETT J MCMILLAN A GALLEGO N | 2004 | Journal of Materials Science2004，39，11： | 1 |
| 8 | 显示文摘 | Klett J W Mcmillan A D Gallego N C | 2004 | Carbon2004，42，89： | 1 |
| 9 | Oxidative stress and apoptosis are induced in human endothelial cells exposed to urban particulate matter显示文摘 | Montiel-D(lvalos A de Ibarra-S(lnchez MJ Ventura- Gallegos JL | 2010 | Toxico] in Vitro2010，24，1： | 1 |
| 10 | Study of the effect of four warm mix asphalt additives on bitumen modified with 15% crumb rubber显示文摘 | RODRiGUEZ ALLOZA A M GALLEGO J PEREZ I | 2013 | Construction and Building Materials2013，43，： | 1 |
| 11 | Effects of heat treatment conditions on the thermal properties of mesopbase pitch derived graphitic foams显示文摘 | KLETT J MCMILLAN A GALLEGO N | 2004 | Carbon2004，42，89： | 1 |
| 12 | Development and validation of a method for air-quality and nuisance odors monitoring of volatile organic compounds using multi-sorbent adsorption and gas chromatography/mass spectrometry thermal desorption system显示文摘 | Ribes A Carrera G Gallego E Roca X Berenguer MJ Guardino X | 2007 | Journal of Chromatography A2007，，1140： | 1 |
| 13 | Prognosis of acute tubular necrosis: an extended prospectively contrasted study显示文摘 | Liano F Gallego A Paseual J | 1993 | Nephron1993，63，1： | 1 |
| 14 | Transmission system expansion planning by simulated annealing显示文摘 | R ROMERO R A GALLEGO A MONTICELLI | | 0，，1： | 1 |
| 15 | High and low temperature properties of crumb rubber modified binders containing warm mix asphalt additives显示文摘 | RODRiGUEZ-ALLOZA A M GALLEGO J PlkREZ I | 2014 | Construction and Building Materials2014，53，： | 1 |
| 16 | Determination of theglass- forming concentration range in binary alloys from asemiempirical theory: application to Zr-based alloys 显示文摘 | Lopez J M Alonso J A Gallego L J | 1987 | Physi-cal Review B Condensed Matter>1987，36，7： | 1 |
| 17 | Lyapunov functions for fractional order systems显示文摘 | AGUILA-CAMACHO N DUARTE-MERMOUD M A GALLEGOS J A | 2014 | Communications in Nonlinear Science and Numerical Simulation2014，19，9： | 1 |
| 18 | Repair of Damaged DNA by Arabidopsis Cell Extract显示文摘 | Li A Schuermann D Gallego F Kovalchuk I Tinland B | 2002 | Plant Cell2002，14，1： | 1 |
| 19 | Thermal integration of heat pumping systems in distillation columns 显示文摘 | P Rivera - Ortega M picon - Nunez E Tortes - reyes A Gallegos - Munoz | 1999 | Applied Thermal Engi- neering1999，19，81： | 1 |
| 20 | Analysis of the conjugate heat transfer in a multi-layer wall including an air layer 显示文摘 | GALLEGOS M A BALDERAS B J ARMANDO V C | 2010 | Applied Thermal Engineering2010，30，： | 1 |
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