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| 1 | Engineering T cells for immunotherapy of primary human hepatocellular carcinoma显示文摘Liver cancers, majority of which are primary hepatocellular carcinoma(HCC), continue to be on the rise in the world. Furthermore, due to the lack of effective treatments, liver cancer ranks the 4th most common cause of male cancer deaths. Novel therapies are urgently needed. Over the last few years,immunotherapies, especially the checkpoint blockades and adoptive cell therapies of engineered T cells,have demonstrated a great potential for treating malignant tumors including HCC. In this review, we summarize the current ongoing research of antigen-specific immunotherapies including cancer vaccines and adoptive cell therapies for HCC. We briefly discuss the HCC cancer vaccine and then focus on the antigen-specific T cells genetically engineered with the T cell receptor genes(TCRTs) and the chimeric antigen receptor genes(CARTs). We first review the current options of TCRTs and CARTs immunotherapies for HCC, and then analyze the factors and parameters that may help to improve the design of TCRTs and CARTs to enhance their antitumor efficacy and safety. Our goals are to render readers a panoramic view of the current stand of HCC immunotherapies and provide some strategies to design better TCRTs and CARTs to achieve more effective and durable antitumor effects. | Leidy DCaraballo Galva Lun Cai Yanxia Shao Yukai He | 2020 | Journal of Genetics and Genomics2020，47，1： | 8 |
| 2 | Lung cancer: What are the links with oxidative stress, physical activity and nutrition 显示文摘 | Filairc E Dupuis C Galvaing G | 2013 | Lung Cancer2013，82，3： | 1 |
| 3 | Effects of lime on permeability and compressibility of two tropical residual soils显示文摘 | Ca' ssia de Brito Galva (-)o T Ahmed Elsharief Gustavo Ferreira Simo (-) es | 2004 | Journal of Environmental Engineering2004，130，8： | 1 |
| 4 | Lung cancer: what are the links with oxidative stress, physical activity and nutrition 显示文摘 | Filaire E Dupuis C Galvaing G | 2013 | Lung Cancer2013，82，3： | 1 |
| 5 | Streptococcus induces circulating CLA+ memory T-Cell-dependent epidermal Cell activation in Psoriasis 显示文摘 | Marta Ferran Ana B Galva n Catalina Rinc 6 n | 2013 | Joumal of Investigative Dermatology2013，133，4： | 1 |
| 6 | Subjective,psychomotor,and physiological effects of cumulative doses of mixed-action opiods in healthy volunteers显示文摘 | Walker DJ Zacny JP Galva KE | 2001 | Psychopharmacology2001，155，4： | 1 |
| 7 | Blunt injury to the thyroid gland: A case of delayed surgical emergency显示文摘Dear editor,Blunt trauma to the thyroid gland is a possibly lifethreatening condition known for years.However,only few cases have been reported in the English-language literature,so that no consensus has emerged as to its workup or management.These injuries are often associated with significant airway obstruction requiring emergent endotracheal tube intubation,surgical removal of the hematoma and | Geraud Galvaing Julien Brehant | 2017 | World Journal of Emergency Medicine2017，8，3： | 1 |
| 8 | ATP protects against FITC labeling of Solanum lycopersicon and Arabidopsis thaliana Ca2+-ATPase ATP bindingdomains显示文摘 | GALVA C VIRGIN G K HELMS J B | 2013 | Plant Physiology Biochemistry2013，71，： | 1 |
| 9 | Genetic diversity among wild common beans from northwestern Argentina based on morpho-agronomic and RAPD data genetic 显示文摘 | Galva M Z Mene M C Sevillano A M | 2006 | Resources and Crop Evolution2006，，53： | 1 |
| 10 | Motor endplate and nerve distribution in a histochemically compartmentalized pinnate muscle in the cat 显示文摘 | Galvas PE Gonyea WJ | 1980 | Am J Anat1980，159，2： | 1 |
| 11 | Subjective,psychomotor,and physiological effects of cumulative doses of mixed-action opioids in healthy volunteers显示文摘 | Walker DJ Zacny JP Galva KE | 2001 | Psychopharmacology2001，155，4： | 1 |
| 12 | Influence of the source and sink temperatures on the optimal re- frigerant charge of a water - to - water heat pump 显示文摘 | Jose' - M Corbera' n Israel Martl' nez - Galva' n Santiago Martl'nez- Ballester | 2011 | International Journal of Refrigeration2011，34，： | 1 |
| 13 | Editor's choice-- hybrid treatment of thoracic, thoracoabdominal, and abdominal aortic aneurysms: a muhicenter retrospective study 显示文摘 | Rosset E Ben Ahmed S Galvaing G | 2014 | Eur J Vasc Endovase Surg2014，47，5： | 1 |
| 14 | Antifungal and antioxidant activities of the phytomedicine pipsissewa,Chimaphila umbellate显示文摘 | Imelda J Galva'n Nadereh Mir-Rashed | 2008 | Phytochemistry2008，69，： | 1 |
| 15 | Role of angiotension converting enzyme inhibitors in congestive heart faihure显示文摘 | Galva M | 2013 | Heart Lung2013，42，： | 1 |
| 16 | Subjective,psychomotor,and physiological effects of cumulative doses of mixed-action opioids in healthy volunteers显示文摘 | Walker DJ Zacny JP Galva KE | 2001 | Psychopharmacology2001，155，4： | 1 |
| 17 | Critical involvement of postsynaptic protein kinase Activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons显示文摘 | Galva′n EJ Cosgrove KE Mauna JC | 2010 | J Neurosci2010，30，8： | 1 |
| 18 | Determination of Blomia tropicalis-specific IgE and IgG subclasses in atopic dermatitis patients显示文摘 | Mori JC Pires MC Galva ~ o CES | 2001 | Allergy2001，56，2： | 1 |
| 19 | The expres- sion of melanin-based plumage is separately modulated by exogenous oxidative stress and a melanocortiu 显示文摘 | Galva'n I Alonso-Alvarez C | 2009 | Proc Biol Sci2009，276，1670： | 1 |
| 20 | Brain regional thallium distribution in rats acutely intoxicated with TI2SO4 显示文摘 | Rios C Galva'n - Arzate S Tapia R | 1989 | Arch Toxicol1989，63，： | 1 |
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