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	题名	作者	年代	出处	被引量
1	The clinicopathological and prognostic significance of PD-L1 expression in pancreatic cancer:A meta-analysis显示文摘Background: Immunotherapy has shown promise against solid tumors. However, the clinical significance of programmed cell death 1(PD-1) and programmed cell death ligand 1(PD-L1) in pancreatic ductal adenocarcinoma(PDAC) remains unclear. This meta-analysis aimed to analyze the prognostic effect of PD-L1 in PDAC.Data sources: Electronic search of the Pub Med, Cochrane Library and Web of Science was performed until December 2016. Through database searches, we identified articles describing the relationship between PD-L1 status and PDAC patient prognosis. Meta-analysis was performed to investigate the relationship between PD-1 and overall survival(OS).Results: Nine studies with 989 PDAC patients were included for PD-L1 expression analysis. And 5 studies with 688 PDAC patients were included in the prognostic analysis. The PD-L1 positive rate measured by immunohistochemistry(IHC) was higher than that measured by polymerase chain reaction(PCR)(P < 0.001). PDAC patients with high expression levels of PD-L1 had significantly reduced OS(HR = 2.34;95% CI: 1.78–3.08). Subgroup analysis showed that the prognostic effect of PD-L1 levels was similar between the IHC and PCR methods. The PD-L1 positive rate was associated with PDAC T stages; the PD-L1 positive rate in the T3–4 group was higher than that in the T1-2 group(OR = 0.37; P = 0.001).Conclusions: High PD-L1 expression levels predicted a poor prognosis in PDAC patients. Thus, PD-L1 status helps determine treatment in PDAC patients.	He-Li Gaoa Liang Liua Zi-Hao Qi Hua-Xiang Xu Wen-Quan Wang Chun-Tao Wu Shi-Rong Zhang Jin-Zhi Xu Quan-Xing Ni Xian-Jun Yua	2018	Hepatobiliary & Pancreatic Diseases International2018，17，2：	13
2	Simultaneous detection for three kinds of veterinary drugs:Chloramphenicol,elenbuterol and 17-beta-estradiol by high-throughput suspension array technology显示文摘	Nan Liua Pu Sua Zhixian Gaoa	2009	Analytica Chimica Acta2009，632，1：	1
3	Actinomycetes for marine drug discovery isolated from mangrove soils and plants in China显示文摘	HongK GaoA H XieQ Y	2009	Marine Drugs2009，，7：	1
4	Electric hot incremental forming: a novel technique 显示文摘	Fan G Q Gaoa L Hossaina G Wu Z L	2008	International Journal of Machine Tools & Manufacture2008，，48：	1
5	Statistical modeling and conceptualization of natural images显示文摘	Jianping Fan Yuli Gaoa Hangzai Luoa	2005	Pattern Recognition2005，38，：	1
6	Phase selection and vis- ible light photo-catalytic activity of Fe-doped TiO2 prepared by the hy- drothermal method 显示文摘	Lin Wana Yun Gaoa Xiao-Hong Xia	2011	Materials Research Bulletin2011，46，3：	1
7	Controlled drug release from hydrogel nanoparticle networks显示文摘	Gang Huanga Jun Gaoa Zhibing Hua	2004	J Controlled Release2004，94，：	1
8	Quantification of components in overlapping peaks from capillary electrophoresis by using continues wavelet transform method 显示文摘	Long Jiaoa Suya Gaoa Fang Zhangb	2008	Talanta2008，75，4：	1
9	Polyethylene glycol modified polyethylenimine for improved CNS gene transfer:effects of PEGylation extent显示文摘	TANGA G P ZENGA J M GAOA S J	2003	Biomaterials2003，24，13：	1
10	Refinement of wavelength calibrations of hyperspectral imaging data using a spectrum-matching technique 显示文摘	Bo-Cai Gaoa Marcos J Montesa Curtiss Davis	2004	Remote Sensing of Environment2004，90，：	1
11	Fungal pathogenprotection in potato by expression of a plant defensin peptide显示文摘	GaoA G Hakimi S M Mittanck C A	2000	Nature Biotechnology2000，18，12：	1
12	Existence, uniqueness and approximation of classical solutions to nonlinear two-point boundary value problems 显示文摘	Taoa Y Gaoa G	2002	Nonlinear Anal2002，50，：	1
13	The enhanced drought tol- erance of rice plants under ammonium is related to aqua- porin (AQP) 显示文摘	Dinga L Gaoa C Lia Y	2015	Plant Science2015，234，：	1
14	Effects of surface charge on the second harmonic generation from a Cu electrode显示文摘	HEWITTA T D GAOA R ROY D	1993	Surface Science1993，291，12：	1
15	Effects of pH on the hierarchical structures and photocatalytic performance of Cu-doped BiVO4 prepared via the hydrothermal method显示文摘	Xiaoming Gaoa Zihang Wang Feng Fua	2015	Materials Science in Semiconductor Processing2015，35，：	1
16	Inhibitory effectonα-glucosidase by Adhatoda vasica Nees显示文摘	Hong Gaoa Yina Huang Bo Gao	2008	FoodChemistry2008，，：	1
17	Design and analysis of pseudorandom number generator compatible with EPC C1G2 tag显示文摘	Gaoa S Wanga H	2012	Journal of Information and Computational Science2012，9，10：	1
18	Polymer Cement Plaster to Prevent Radon Gas Contamination Within Concrete Building Structures显示文摘	Gaoa X F Tam C M Gao W Z	2002	Building and Environment2002，37，：	1
19	Preparation and characteristic of carbon-coated Li4Ti5O12 anode material显示文摘	WANG G J GAOA L FUA L J	2007	Journal of Power Sources2007，174，11：	1
20	Effects of metal oxides on electrochemical hydrogen storage of nanocrystalline LaMg12-Ni composites 显示文摘	Wanga Y Gaoa X P Lua Z W	2005	Electrochimica Acta2005，50，：	1

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