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| 1 | Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis显示文摘AIM:To identify and characterize drosophila mothers against decapentaplegic(SMAD)3-dependent changes in immune cell populations following infection with Helicobacter hepaticus(H.hepaticus).METHODS:SMAD3 -/-(n=19)and colitis-resistant SMAD3+/-(n=24)mice(8-10 wk of age)were in-fected with H.hepaticus and changes in immune cell populations[T lymphocytes,natural killer(NK)cells,T regulatory cells]were measured in the spleen and mesenteric lymph nodes(MsLNs)at 0 d,3 d,7 d and 28 d post-infection using flow cytometry.Genotypedependent changes in T lymphocytes and granzyme B+ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry.RESULTS:As previously observed,SMAD3 -/-,but not SMAD3+/-mice,developed colitis,peaking at 4 wk post-infection.No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point.However,CD4+and CD8+/ CD62Llo cells,an effector T lymphocyte population,as well as NK cells(NKp46/DX5+)were significantly higher in the MsLNs of SMAD3-/-mice at 7 d and 28 d post-infection.In the colon,a higher number of CD3+cells were present in SMAD3-/-compared to SMAD3+/-mice at baseline,which did not significantly change during infection.However,the number of granzyme B+cells,a marker of cytolytic lymphocytes,significantly increased in SMAD3-/-mice 28 d post-infection compared to both SMAD3+/-mice and to baseline values.This was consistent with more severe colitis development in these animals.CONCLUSION:Data suggest that defects in SMAD3 signaling increase susceptibility to H.hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes. | Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，13： | 2 |
| 2 | Elastic wave velocities in heterogeneous and porous media 显示文摘 | Wyllie M R J Gregory A R Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 3 | Hemoglobins dioxygenate nitric oxide with high fidelity显示文摘 | Gardner P R Gardner A M Brashear W T | 2006 | J Inorg Biochem2006，100，4： | 1 |
| 4 | Fixation of posterior malleolar fractures provides greater syndesmotic stability显示文摘 | Gardner M J Brodsky A Briggs SM | 2006 | Clin Orthop Relat Res2006，447，： | 1 |
| 5 | Extreme population differences across Neuregulin 1 gene,with implications for association studies显示文摘 | Gardner M González-Neira A Lao O | 2006 | Mol Psychiatry2006，11，1： | 1 |
| 6 | Electronic noses-development and future prospects 显示文摘 | Craven M A Gardner J W | 1996 | Trends in analytical chemistry1996，15，9： | 1 |
| 7 | Dynamic Analysis of Riser and Caissions by the Element Method显示文摘 | Gardner T N Kotch M A | 1976 | OTC 26511976，，3： | 1 |
| 8 | Principles of Endoneurosurgery显示文摘 | KASSAM A B GARDNER P A PREVEDELLO D M | 2012 | Prog Neurol Surg2012，26，： | 1 |
| 9 | Elastic wave velocities in heterogeneous and porous media 显示文摘 | Wyllie M R J Gregory A R and Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 10 | Organizational socialization:Its content and consequences 显示文摘 | Chao G T O' Leary-Kelly A M Wolf S Klein H J Gardner P D | 1994 | Journal of Applied Psychol- ogy1994，79，5： | 1 |
| 11 | Towards a full model of second language learning, an empirical investigation显示文摘 | Gardner R C Trembley P F Masgoret A M | 1997 | The Modem Language Journal1997，，81： | 1 |
| 12 | Cyclic Spectral Analysis for Signal Detection and Modulation Recognition 显示文摘 | Gardner W A Spooner C M | 1988 | IEEE1988，25，37988： | 1 |
| 13 | Elastic wave velocities in heterogeneous and porous media显示文摘 | Wyllie M R J Gregory A R Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 14 | Molecular regulation of tumor cell vasculogenic mimicry by tyrosine phosphorylation:role of epithelial cell kinase (Eck/EphA2)显示文摘 | HESS A R SEFTOR E A GARDNER L M | 2001 | Cancer Res2001，61，8： | 1 |
| 15 | A sigle-staged technique for seeing vascular grafts with autogenous endothelium显示文摘 | Herring M Gardner A Glover J | 1978 | Surgery1978，84，： | 1 |
| 16 | An experimental investigation of factors affecting elastic wave velocities in porous media显示文摘 | Wyllie M R J Gregory A R and Gardner L W | 1958 | 23 (3) : 459-4931958，23，3： | 1 |
| 17 | A semi-empirical model for the X-ray Si (Li) detetor response function 显示文摘 | Yaeout A M Gardner R P Verghese K | 1986 | Nuclear Instrument and Methods in Physics Research A1986，243，1： | 1 |
| 18 | The cumulant theory of cyclostationary time-series,Part I-II显示文摘 | Gardner W A Spooner C M | | 0，，12： | 1 |
| 19 | Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer显示文摘 | Improgo M R Tapper A R Gardner P D | | 0，，8： | 1 |
| 20 | Building successful logistics partnerships 显示文摘 | LAMBERT D M EMMELHAINZ M A GARDNER J T | 1999 | Journal of Business Logistics1999，20，1： | 1 |
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