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| 1 | Thrombin activation and liver inflammation in advanced hepatitis C virus infection显示文摘Hepatitis C virus(HCV) infection is associated with increased thrombotic risk. Several mechanisms are involved including direct endothelial damage by the HCV virus, with activation of tissue factor, altered fibrinolysis and increased platelet aggregation and activation. In advanced stages, chronic HCV infection may evolve to liver cirrhosis, a condition in which alterations in the portal microcirculation may also ultimately lead to thrombin activation, platelet aggregation, and clot formation. Therefore in advanced HCV liver disease there is an increased prevalence of thrombotic phenomena in portal vein radicles. Increased thrombin formation may activate hepatic stellate cells and promote liver fibrosis. In addition, ischemic changes derived from vascular occlusion by microthrombi favor the so called parenchymal extinction, a process that promotes collapse of hepatocytes and the formation of gross fibrous tracts. These reasons may explain why advanced HCV infection may evolve more rapidly to end-stage liver disease than other forms of cirrhosis. | Emilio González-Reimers Geraldine Quintero-Platt Candelaria Martín-González Onán Pérez-Hernández Lucía Romero-Acevedo Francisco Santolaria-Fernández | 2016 | World Journal of Gastroenterology2016，22，18： | 5 |
| 2 | Liver steatosis in hepatitis C patients显示文摘There is controversy regarding some aspects of hepatitis C virus(HCV) infection-associated liver steatosis,and their relationship with body fat stores. It has classically been found that HCV,especially genotype 3,exerts direct metabolic effects which lead to liver steatosis. This supports the existence of a so called viral steatosis and a metabolic steatosis,whichwould affect HCV patients who are also obese or diabetics. In fact,several genotypes exert metabolic effects which overlap with some of those observed in the metabolic syndrome. In this review we will analyse the pathogenic pathways involved in the development of steatosis in HCV patients. Several cytokines and adipokines also become activated and are involved in 'pure' steatosic effects,in addition to inflammation. They are probably responsible for the evolution of simple steatosis to steatohepatitis,making it difficult to explain why such alterations only affect a proportion of steatosic patients. | Emilio González-Reimers Geraldine Quintero-Platt Melchor Rodríguez-Gaspar Remedios Alemán-Valls Onán Pérez-Hernández Francisco Santolaria-Fernández | 2015 | World Journal of Hepatology2015，7，10： | 3 |
| 3 | Adipokines,cytokines and body fat stores in hepatitis Cvirus liver steatosis显示文摘AIM: To identify patients with or without liver steatosis and its severity in treatment-na?ve patients affected by hepatitis C virus(HCV) infection.METHODS: We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body(by densitometry), hormones [insulin, homeostatic model assessment(HOMA)], adipokines(resistin, adiponectin, leptin), and cytokines(tumor necrosis factor α, interleukin-6).RESULTS: Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunkfat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and resistin.CONCLUSION: Steatosis in HCV infection is common(67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines. | emilio gonzález-reimers javier lópez-prieto geraldine quintero-platt ricardo pelazas-gonzález m remedios alemán-valls onán pérez-hernández m joséde-la-vega-prieto m angeles gómez-rodríguez candelaria martín-gonzález francisco santolaria-fernández | 2016 | World Journal of Hepatology2016，8，1： | 2 |
| 4 | Microbial hydrolysis of methyl aromatic esters by Burkholderia cepacia iso- lated from soil显示文摘 | Geraldine P Danielle V Jean B | 2001 | FEMS Microbiology Ecology2001，37，： | 1 |
| 5 | Antioxidant activity of the oyster mushroom, Pleurotus ostreatus on CCl,-induced liver injury in rats显示文摘 | JAYAKUMAR T RAMESH E GERALDINE P | 2006 | Food and Chemical Toxicology2006，44，： | 1 |
| 6 | Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori显示文摘 | Céu Figueiredo Wim G.V Quint Ricardo Sanna Erwin Sablon John P Donahue Qing Xu Geraldine G Miller Richard M Peek Martin J Blaser Leen-Jan van Doorn | 2000 | Gene2000，，1： | 1 |
| 7 | Histopathology of the hepatopan- creas and gills of the prawn Macrobrachium macolmsoniiexposed to endosulfan显示文摘 | Bhavan P S Geraldine P | 2000 | Aquat Toxicol2000，50，： | 1 |
| 8 | Protective effect of an extract of the oyster mushroom, Pleurotus ostreatus, on antioxidants of major organs of aged rats显示文摘 | JAYAKUMAR T THOMAS P A GERALDINE P | 2007 | Experimental Gerontology2007，42，3： | 1 |
| 9 | Biochemical stress responses in tissues of the prawn macrobrachium malcolmsonii on exposure to endosulfan显示文摘 | BHAVAN P S GERALDINE P | 2001 | Pesticide Biochemistry and Physiology2001，70，： | 1 |
| 10 | ABCB1 1199G>A genetic polymorphism(Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines显示文摘 | Geraldine D Laure E Nadtha P | 2014 | PloS One2014，9，4： | 1 |
| 11 | Comparisonof in vitro susceptibilities of ocular bacterial iso-lates to gatifloxacin andother topical antibiotics显示文摘 | Kaliamurthy J Nelson Jesudasan CA Geraldine P | 2005 | Ophthal-mic Res2005，37，3： | 1 |
| 12 | Microbial hydrolysis of methyl aromatic esters by Burkholderia cepacia isolated from soil 显示文摘 | Geraldine P Danielle V Jean B | 2001 | FEMS Microbiology Ecology2001，37，： | 1 |
| 13 | Regula-tory effect of acetyl-l-camitine on expression of lenticular an-tioxidant and apoptotic genes in selenite-induced cataract显示文摘 | Elanchezhian R Sakthivel M Geraldine P Thomas PA | 2010 | Chem Biol Interact2010，184，3： | 1 |
| 14 | Antioxidanl activily of the oyster mushroom, Pleurotus ostreatus, on CCI ( 4 ) - induced liver injury in rats 显示文摘 | Jayakumar T Ramesh E Geraldine P | 2006 | Food and chemical toxicology :all international journal published for the British Industrial Biological Research Association2006，44，12： | 1 |
| 15 | Comparison of in vitro susceptibilities of ocular bacterial isolates to gatifloxacin and other topical antibiotics显示文摘 | Kaliamurthy J Nelson Jesudasan CA Geraldine P | 2005 | Ophthalmic Res2005，37，3： | 1 |
| 16 | Effects of dichlorvos intoxication in the freshwater prawn, Macrobrachium malcolmsonii 显示文摘 | Geraldine P Bhavan P S Kaliamurthy J | 1999 | J Environ Biol1999，20，： | 1 |
| 17 | Microbial hydrolysis of methyl aromatic esters by Burkholderia cepacia isolated from soil 显示文摘 | Geraldine P Danielle V Jean B | 2001 | FEMS Microbiology Ecology2001，37，： | 1 |
| 18 | Effects of dichlorvos intoxication in the freshwater prawn, Macrobrachium malcolmsonii显示文摘 | Geraldine P Bhavan P S Kaliamurthy J | 1999 | Journal of Environmental Biology1999，20，2： | 1 |
| 19 | Antihyperglycemic and antioxidant effects of a flavanone, naringenin, in streptozotocin-nicotinamide-induced experimental diabetic rats显示文摘 | Annadurai T Muralidharan AR Joseph T Hsu MJ Thomas PA Geraldine P | 2012 | J Physiol Biochem2012，68，3： | 1 |
| 20 | Comparison of in vitro susceptibilities of ocular bacterial isolates to gatifloxacin and other topical antibiotics显示文摘 | Kaliamurthy J Nelson Jesudasan CA Geraldine P | 2005 | Ophthalmic Res2005，37，3： | 1 |
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