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| 1 | Single-operator cholangioscopy for biliary complications in liver transplant recipients显示文摘AIM To evaluate cholangioscopy in addition to endoscopic retrograde cholangiopancreatography(ERCP) for management of biliary complications after liver transplantation(LT).METHODS Twenty-six LT recipients with duct-to-duct biliary reconstruction who underwent ERCP for suspected biliary complications between April and December2016 at the university hospital of Muenster were consecutively enrolled in this observational study. After evaluating bile ducts using fluoroscopy, cholangioscopy using a modern digital single-operator cholangioscopy s y s t e m(S py G la s s D S ?) wa s pe r fo r me d dur ing the same procedure with patients under conscious sedation. All patients received peri-interventional antibiotic prophylaxis and bile was collected during the intervention for microbial analysis and for antibiotic susceptibility testing.RESULTS Thirty-three biliary complications were found in a total of 22 patients, whereas four patients showed normal bile ducts. Anastomotic strictures were evident in 14(53.8%) patients, non-anastomotic strictures in seven(26.9%), biliary cast in three(11.5%), and stones in six(23.1%). A benefit of cholangioscopy was seen in 12(46.2%) patients. In four of them, cholangioscopy was crucial for selective guidewire placement prior to planned intervention. In six patients, biliary cast and/or stones failed to be diagnosed by ERCP and were only detectable through cholangioscopy. In one case, a bile duct ulcer due to fungal infection was diagnosed by cholangioscopy. In another case, signs of bile duct inflammation caused by acute cholangitis were evident. One patient developed post-interventional cholangitis. No further procedure-related complications occurred. Thirty-seven isolates were found in bile. Sixteen of these were gram-positive(43.2%), 12(32.4%) were gram-negative bacteria, and Candida species accounted for 24.3% of all isolated microorganisms. Interestingly, only 48.6% of specimens were sensitive to prophylactic antibiotics.CONCLUSION Single-operator cholangioscopy can provide important diagnostic information, helping endoscopists to plan and perform interventional procedures in LT-related biliary complications. | Anna Hüsing-Kabar Hauke Sebastian Heinzow Hartmut Hans-Jürgen Schmidt Carina Stenger Hans Ulrich Gerth Michele Pohlen Gerold Tholking Christian Wilms Iyad Kabar | 2017 | World Journal of Gastroenterology2017，23，22： | 4 |
| 2 | Chemical analysis and bonding reaction of RelyX Unicem and Bifix composites-A comparative study显示文摘 | Gerth HU Dammaschke T Zuchner H | 2006 | Dent Mater2006，22，10： | 1 |
| 3 | Studies on the biosynthesis of epothilones : hydroxylation of Epo A and B to epothilones E and F显示文摘 | Gerth K Steinmetz H Hoflel G | 2002 | J Antibiot2002，55，1： | 1 |
| 4 | New natural epothilones from Sorangium cellulosum, strains so ce90/b2 and so ce90/d13: isolation, structure elucidation, and SAR studies显示文摘 | Hardt IH Steinmetz H Gerth K | 2001 | J Nat Prod2001，64，7： | 1 |
| 5 | Myxobacteria : A source of new antibiotics 显示文摘 | REICHENBACH H GERTH K IRSCHIK H | 1988 | Trends Biotechnol1988，6，： | 1 |
| 6 | New natural epothilones from Sporangium cellulosum, strains so ce 90/B2 and so ce 90/D13 :isolation, structure elucidation and SAR studies显示文摘 | Hardt IH Steinmetz H Gerth K | 2001 | J Nat Prod2001，64，7： | 1 |
| 7 | Studies on the biosynthesis of epothilones: the biosynthetic origin of carbon skeleton 显示文摘 | Gerth K Steinmetz H Hofle G | 2000 | J Antibiot2000，53，12： | 1 |
| 8 | Clp-dependent proteolysisdown-regulates central metabolic pathways in glucose-starved Ba-cillus subtilis 显示文摘 | Gerth U Kock H Kusters I | 2008 | J Bacteriol2008，190，1： | 1 |
| 9 | , Studies on the biosynthesis of epothilones: Hydroxylation of epothilones A and B to epothilones E and F显示文摘 | Gerth K Steinmetz H Hoflel G | 2002 | J Antibiot2002，55，1： | 1 |
| 10 | Induction of p27KIPI after unilate ral ureteral obstruction is independent of angiotensin 11 显示文摘 | Gerth J H Kriegsmann J Trinh TT | 2002 | Kidney Int2002，，1： | 1 |
| 11 | Studies on the biosynthesis of epothilones: the PKS and epothilone C/D monooxygenase显示文摘 | Gerth K Steinmetz H Hofle G | 2001 | J Antibiot2001，54，2： | 1 |
| 12 | Studies on the biosynthesis of epothilones 显示文摘 | Steinmetz H Hofle G | 2001 | J Antibiot2001，54，2： | 1 |
| 13 | Standardizing double-blind,placebo-controlled oral food challenges:American Academy of Allergy,Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report显示文摘 | SAMPSON H A GERTH van WIJK R BINDSLEV-JENSEN C | 2012 | Journal of Allergy and Clinical Immunology2012，130，6： | 1 |
| 14 | Studies on the Bio- synthesis of Epothilones : the PKS and Epothilone C/D Monoxy- genase 显示文摘 | Gerth K Steinmetz H Ho ofle G | 2001 | J Antibiot2001，54，2： | 1 |
| 15 | The myxovirescins,a family of antibiotics from Myxococcus virescens (Myxobacterales)显示文摘 | Gerth K Irschik H Reichenbach H | 1982 | J Antibiot (Tokyo)1982，35，11： | 1 |
| 16 | Chemical and physical surface and bulk material characterization of white Pro- Root MTA and two Portland cements显示文摘 | Dammaschke T Gerth HUV Zuchner H | 2005 | Dent Mater2005，21，8： | 1 |
| 17 | Studies on the biosynthesis of epothilones: hydroxylation of Epo A and B to epothilones E and F显示文摘 | Steinmetz H Hofle G | 2002 | J Antibiot2002，55，1： | 1 |
| 18 | Studies on the biosynthesis of epothilones: the biosynthetic origin of the carbon skeleton 显示文摘 | Steinmetz H Hofle G | 2000 | J Antibiot2000，53，12： | 1 |
| 19 | The soraphens:a family of novel antifungal compounds from Sorangium cellulosum (myxobacteria)显示文摘 | GERTH K BEDORF N IRSCHIK H | | 0，，： | 1 |
| 20 | Evalua- tion of clinical and immunological responses : a 2-year fol- low-up study in children with allergic rhinitis due to house dust mite 显示文摘 | Moed H Gerth van Wijk R Hendriks R W et at | 2013 | Mediators Inflamm2013，2013，34： | 1 |
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