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| 1 | Carcinoma in situ in a 7 mm gallbladder polyp: Time to change current practice?显示文摘Detection of polypoid lesions of the gallbladder is increasing in conjunction with better imaging modalities. Accepted management of these lesions depends on their size and symptomatology. Polyps that are symptomatic and/or greater than 10 mm are generally removed, while smaller, asymptomatic polyps simply monitored. Here, a case of carcinoma-in-situ is presented in a 7 mm gallbladder polyp. A 25-year-old woman, who had undergone a routine cholecystectomy, was found to have an incidental 7 mm polyp containing carcinoma in situ. She had few to no risk factors to alert to her condition. There are few reported cases of cancer transformation in gallbladder polyps smaller than 10 mm reported in the literature. The overwhelming consensus, barring significant risk factors for cancer being present, is that such lesions should be monitored until they become symptomatic or develop signs suspicious for malignancy. In our patient's case this could have led to the possibility of missing a neoplastic lesion, which could then have gone on to develop invasive cancer. As gallbladder carcinoma is an aggressive cancer, this may have led to a tragic outcome. | David Kasle Amir A Rahnemai-Azar Shahida Bibi Vinaya Gaduputi Brian F Gilchrist Daniel T Farkas | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 8 |
| 2 | Laparoscopic vs open partial colectomy in elderly patients:Insights from the American College of Surgeons- National Surgical Quality Improvement Program database显示文摘AIM: To compare the outcomes between the laparoscopic and open approaches for partial colectomy in elderly patients aged 65 years and over using the American College of Surgeons- National Surgical Quality Improvement Program(ACS NSQIP) database. METHODS: The ACS NSQIP database for the years 2005-2011 was queried for all patients 65 years and above who underwent partial colectomy. 1:1 propensity score matching using the nearest- neighbor method was performed to ensure both groups had similar preoperative comorbidities. Outcomes including postoperative complications, length of stay and mortality were compared between the laparoscopic and open groups. χ2 and Fisher's exact test were used for discrete variables and Student's t-test for continuous variables. P < 0.05 was considered significant and odds ratios with 95%CI were reported when applicable. RESULTS: The total number of patients in the ACS NSQIP database of the years 2005-2011 was 1777035. We identified 27604 elderly patients who underwent partial colectomy with complete data sets. 12009(43%) of the cases were done laparoscopically and15595(57%) were done with open. After propensity score matching, there were 11008 patients each in the laparoscopic(LC) and open colectomy(OC) cohorts. The laparoscopic approach had lower post-operative complications(LC 15.2%, OC 23.8%, P < 0.001), shorter length of stay(LC 6.61 d, OC 9.62 d, P < 0.001) and lower mortality(LC 1.6%, OC 2.9%, P < 0.001). CONCLUSION: Even after propensity score matching, elderly patients in the ACS NSQIP database having a laparoscopic partial colectomy had better outcomes than those having open colectomies. In the absence of specific contraindications, elderly patients requiring a partial colectomy should be offered the laparoscopic approach. | Umashankkar Kannan Vemuru Sunil K Reddy Amar N Mukerji Vellore S Parithivel Ajay K Shah Brian F Gilchrist Daniel T Farkas | 2015 | World Journal of Gastroenterology2015，21，45： | 3 |
| 3 | Chapter 21 The financial accelerator in a quantitative business cycle framework显示文摘 | Ben S. Bernanke Mark Gertler Simon Gilchrist | 1999 | Handbook of Macroeconomics1999，，： | 3 |
| 4 | 生物毒素的研究与应用:选择性蜘蛛毒揭示Nav1.1通道在机械痛中的作用显示文摘电压门控性钠(Nav)通道参与启动大多数神经元动作电位,其中也包括痛觉初级传入神经纤维。局部麻醉剂可通过非特异性阻断所有Nav通道亚型来抑制疼痛,但探求选择性亚型调节因子将更有助于分析Nav通道亚型对化学、机械或热痛的作用及机制。美国加州大学旧金山分校的Jeremiah D.Osteen,Volker Herzig和David Julius等人通过运用电生理、组织化学及行为学,筛选和鉴定出一种蜘蛛毒素可选择性激活Nav1.1亚基,并阐明其在伤害感受和疼痛中的作用。在非神经炎症的情况下,Nav1.1的激活诱导了疼痛反应,产生了机械性痛觉过敏,而对热痛并无影响。在肠道中,高阈值机械敏感性神经纤维表达Nav1.1,且肠易激综合征模型小鼠也表现为毒素敏感性增强,证实了Nav1.1通道在调节机械痛的感觉神经纤维兴奋性中的作用。 | Jeremiah D.Osteen Volker Herzig John Gilchrist 余书敏 | 2017 | 中国疼痛医学杂志2017，23，2： | 3 |
| 5 | WONCA研究论文摘要汇编——初级医疗团队社会网络对心血管疾病患者医疗质量和费用的效果研究显示文摘目的心血管疾病是美国人口死亡与发病的首要原因。初级医疗团队可以最大化地提高心血管疾病患者的医疗质量,降低医疗成本。本研究探讨初级医疗团队交流、互动、协作(即社会网络)与心血管疾病医疗质量、费用之间的关系。方法从6家初级医疗诊所的31个团队中,选取155名专业医护人员进行社会经济调查,确保调查对象日常进行医疗互动。通过社会网络分析,计算团队互动密度与集中度变量。采用三级模式分析法,评估团队社会网络密度、集中度与过去12个月内控制血压和胆固醇的心血管疾病患者数量、上门急救次数、急诊室来访次数、住院天数、医疗费用之间的关系。结果医疗团队成员的互动密度越大,心血管疾病患者的住院天数就越少〔RR=0.62,95%CI(0.50,0.77)〕,医疗费用就越低〔-$556,95%CI(-$781,-$331)〕。相反,如团队围绕少数个体进行更集中的互动,患者的住院天数就越多〔RR=1.45,95%CI(1.09,1.94)〕,医疗费用就越高〔$506,95%CI($202,$810)〕。团队内部就目标进行分享与沟通,能够调整社会网络结构与医疗质量之间的关系。结论增强初级医疗团队互动,降低互动集中度,共享团队目标,可以凭借更少的医疗成本获得高质量的心血管医疗服务。 | Mundt MP Gilchrist VJ Fleming MF 本刊编辑部 | 2015 | 中国全科医学2015，18，11： | 3 |
| 6 | Tracking invasion and invasiveness in Queensland fruit flies: From classical genetics to 'omics'显示文摘 | William B. SHERWIN Marianne FROMMER John A. SVED Kathryn A. RAPHAEL John G. OAKESHOTT Deborah C.A. SHEARMAN A. Stuart GILCHRIST | 2015 | Current Zoology2015，61，3： | 3 |
| 7 | Do stock price bubbles influence corporate investment?显示文摘 | Simon Gilchrist Charles P. Himmelberg Gur Huberman | 2005 | Journal of Monetary Economics2005，，4： | 2 |
| 8 | Manufacturing of thermoplastic composites from commingled yarns -A review 显示文摘 | Svensson N Shishoo R Gilchrist M | 1998 | Journal of Thermoplastic Composite Materials1998，11，1： | 2 |
| 9 | Langerhans cell histiocytosis: Diagnosis, natural history, management, and outcome显示文摘 | Howarth DM Gilchrist GS Mullan BP | 1999 | Cancer1999，85，： | 1 |
| 10 | Detection of viable but nonculturable Escherichia coli 0157:H7 bacteria in drinking wa- ter and fiver water显示文摘 | Liu YM Gilchrist A Zhang J | 2008 | Appl Environ Microb2008，74，5： | 1 |
| 11 | Alfacalcidol is a nontoxic,effective treatment of follicular small-cleaved cell lymphoma显示文摘 | Raina V Cunningham D Gilchrist N | 1991 | BrJ Cancer1991，63，3： | 1 |
| 12 | Low numbers of CSF blasts at diagnosis do not predict for the development of CNS leukemia in children with intermediate-risk acute lymphoblastic leukemia:a Children's Cancer Group report显示文摘 | Gilchrist GS Tubergen DG Sather HN | 1994 | J Clin Oncol1994，12，2： | 1 |
| 13 | Localization ofVGLUT3 ,the vesicular glutamate transporter type 3 , inthe rat brain显示文摘 | Herzog E Gilchrist J Gras C | 2004 | Neuroscience2004，123，4： | 1 |
| 14 | Changes in lactate-pro- ducing and lactate-utilizing bacteria in relation to pH in the rumen of sheep during stcpwise adaptation to a high-concen- trate diet 显示文摘 | MACKIE R I GILCHRIST F M C | 1979 | Applied and Environmental Microbiology1979，38，3： | 1 |
| 15 | Aromatic amino acid biosynthesis and its regulation显示文摘 | Kosuge T Gilchrist DG | 1980 | Biocem plant1980，，5： | 1 |
| 16 | Palliation of recurrent Ewing sarcoma of the pelvis with cryoablation and somatosensory-evoked potentials显示文摘 | Lessard AM Gilchrist J Schaefer L | 2009 | J Pediatr Hematol Oncol2009，31，： | 1 |
| 17 | Neutrophil defensins induce histamine secretion from mast cells: Mechanisms of action 显示文摘 | Befus A D Mowat C Gilchrist M | 1999 | Immunol1999，163，1： | 1 |
| 18 | The Financial Accelerator in a Quantitative Business Cycle Framework显示文摘 | Bernanke B Gertler M Gilchrist S | 1996 | Handbook of Macroeconomics1996，，1： | 1 |
| 19 | Immunoneutralization of growth differentiation factor-9 reveal it partially accounts for mouse oocyte mitogenic activity显示文摘 | GILCHRIST R B RITTER L J CRANFIELD M | 2004 | Biol Reprod2004，71，3： | 1 |
| 20 | Does Stock Price Influence Corporate Investment? 显示文摘 | Gilchrist S C P Himmelberg G Huberman | 2004 | Federal Reserve Bank of New York Staff Reports2004，177，： | 1 |
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