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| 1 | A complete compilation of matrix metalloproteinase expression in human malignant gliomas显示文摘Glioblastomas are characterized by an aggressive local growth pattern, a marked degree of invasiveness and poor prognosis. Tumor invasiveness is facilitated by the increased activity of proteolytic enzymes which are involved in destruction of the extracellular matrix of the surrounding healthy brain tissue. Elevated levels of matrix metalloproteinases(MMPs) were found in glioblastoma(GBM) cell-lines, as well as in GBM biopsies as compared with low-grade astrocytoma(LGA) and normal brain samples, indicating a role in malignant progression. A careful review of the available literature revealed that both the expression and role of several of the 23 human MMP proteins is controversely discussed and for some there are no data available at all. We therefore screened a panel of 15 LGA and 15 GBM biopsy samples for those MMPs for which there is either no, very limited or even contradictory dataavailable. Hence, this is the first complete compilation of the expression pattern of all 23 human MMPs in astrocytic tumors. This study will support a better understanding of the specific expression patterns and interaction of proteolytic enzymes in malignant human glioma and may provide additional starting points for targeted patient therapy. | Carsten Hagemann Jelena Anacker Ralf-Ingo Ernestus Giles H Vince | 2012 | World Journal of Clinical Oncology2012，3，5： | 18 |
| 2 | Terahertz endoscopic imaging for colorectal cancer detection:Current status and future perspectives显示文摘Terahertz(THz) imaging is progressing as a robust platform for myriad applications in the field of security,health,and material science.The THz regime,which comprises wavelengths spanning from microns to millimeters,is non-ionizing and has very low photon energy:Making it inherently safe for biological imaging.Colorectal cancer is one of the most common causes of death in the world,while the conventional screening and standard of care yet relies exclusively on the physician's experience.Researchers have been working on the development of a flexible THz endoscope,as a potential tool to aid in colorectal cancer screening.This involves building a single-channel THz endoscope,and profiling the THz response from colorectal tissue,and demonstrating endogenous contrast levels between normal and diseased tissue when imaging in reflection modality.The current level of contrast provided by the prototype THz endoscopic system represents a significant step towards clinical endoscopic application of THz technology for invivo colorectal cancer screening.The aim of this paper is to provide a short review of the recent advances in THz endoscopic technology and cancer imaging.In particular,the potential of single-channel THz endoscopic imaging for colonic cancer screening will be highlighted. | Pallavi Doradla Cecil Joseph Robert H Giles | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，8： | 3 |
| 3 | Blade row interaction effects on compressor measurement 显示文摘 | Shang T Epstein A H Giles M B | 1993 | Journal of Propulsion and Power1993，9，4： | 2 |
| 4 | Work - life Benefits and Positive Organizational Behavior:Is There A Connection 显示文摘 | Muse L Harris S G Giles W F Feild H S | 2008 | Journal of Or- ganizational Behavior2008，29，2： | 1 |
| 5 | Vegetation changes in a river oasis on the southern rim of the Taklamakan Desert in China between 1956 and 2000显示文摘 | Bruelheide H Jandt U Giles D | 2003 | Phytocoenologia2003，33，4： | 1 |
| 6 | Platelet glycoprotein Ⅱb/Ⅲa and size are incresed in acute myocardial infarction显示文摘 | GILES H SMITH R E MARTIN J F | | 0，，： | 1 |
| 7 | Caught up in a Wnt storm~ Wnt signaling in cancer显示文摘 | Giles R H van Es J H Clevers H | 2003 | Biochim Biophys Acta2003，1653，： | 1 |
| 8 | Deranged liver blood flow patterns in the detection of liver metastases显示文摘 | Leveson S H Wiggins P H Giles G R | 1985 | Br J Surg1985，72，2： | 1 |
| 9 | Platelet glycoprotein IIbIIIa and size are increased in a-cute myocardial infarction显示文摘 | Giles H Smith REA Martin JF | 2008 | Eur J Clin Invest2008，，1： | 1 |
| 10 | Cardiac pacemaking in the sinoat-rial node显示文摘 | Irisawa H Brown HF Gile W | 1993 | Physiol Rev1993，73，1： | 1 |
| 11 | Treatment of newly diagnosed AML and MDS with cyclophosphamide,ara-C and topotecan 显示文摘 | Estey E Kantarjian H Giles F | 1998 | Blood1998，，： | 1 |
| 12 | New insights into the pathophysiology of chronic myeloid leukemia and imatinib resistance显示文摘 | KANTARJIAN H M TALPAZ M GILES F | 2006 | Ann Intern Med2006，145，： | 1 |
| 13 | Prevalence of the metabolic syndrome among US adults: findings from the third national health and nutrition examination survey 显示文摘 | Ford E S Giles W H Dietz W H | 2002 | Jama2002，287，3： | 1 |
| 14 | Caught up in a Wnt storm:Wnt signaling in cancer显示文摘 | Giles RH van Es JH Clevers H | | 0，，： | 1 |
| 15 | A General treatment and classification of the solute adsorption isotherm theoretical显示文摘 | Giles C H Smith D Huitson A | 1974 | J Colloid Interface Science1974，47，： | 1 |
| 16 | Caught up in a Wnt storm: Wnt signaling in cancer显示文摘 | Giles RH Van ES JH Clevers H | 2003 | Biochim Biophys Acta2003，1653，10： | 1 |
| 17 | What is the optimal duration of ventilation in the prone position in acute lung injury and acute respiratory distress syndrome? 显示文摘 | McAuley DF Giles S Fichter H | 2002 | Intensive Care Med2002，28，4： | 1 |
| 18 | Twelve steps to heaven: Successfully managing change through developing innovative teams 显示文摘 | West Giles H Andreas R | 2004 | European Journal of Work and Organization Psychology2004，13，2： | 1 |
| 19 | Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey显示文摘 | Ford Earl S Giles Wayne H Dietz william H | 2002 | JAMA2002，287，3： | 1 |
| 20 | Symbolic Actions Used by Business Turnaround Change Agents 显示文摘 | Amaenakis A Fredenberger W Chemnes L Held H Giles W Holley W | 1995 | Academy of Management Best Papers Proceedings1995，1，： | 1 |
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