|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment显示文摘Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver fibrosis.Moreover,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective studies.Notwithstanding,patients with NAFLD have an elevated prevalence of prediabetes.Recent studies have shown that NAFLD presence predicts the development of type2 diabetes.Diabetes and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic patients.The diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic method.An effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are lacking.We sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus. | Nathalie C Leite Cristiane A Villela-Nogueira Claudia R L Cardoso Gil F Salles | 2014 | World Journal of Gastroenterology2014，20，26： | 21 |
| 2 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 3 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 4 | Intraoperative laparoscopic complications for urological cancer procedures显示文摘AIM: To structure the rate of intraoperative complications that requires an intraoperative or perioperative resolution. METHODS: We perform a literature review of Medline database. The research was focused on intraoperative laparoscopic procedures inside the field of urological oncology. General rate of perioperative complications in laparoscopic urologic surgery is described to be around 12.4%. Most of the manuscripts published do not make differences between pure intraoperative, intraoperative with postoperative consequences and postoperative complications. RESULTS: We expose a narrative statement of complications, possible solutions and possible preventions for most frequent retroperitoneal and pelvic laparoscopic surgery. We expose the results with the following order: retroperitoneal laparoscopic surgery(radical nephrectomy, partial nephrectomy, nephroureterectomy and adrenalectomy) and pelvic laparoscopic surgery(radical prostatectomy and radical cystectomy).CONCLUSION: Intraoperative complications vary from different series. More scheduled reports should be done in order to better understand the real rates of complications. | Sergio Fernández-Pello Montes Ivan Gonzalez Rodríguez Rodrigo Gil Ugarteburu Luis Rodríguez Villamil Begoa Diaz Mendez Patricio Suarez Gil Javier Mosquera Madera | 2015 | World Journal of Clinical Cases2015，3，5： | 4 |
| 5 | Powder metallurgy with space holder for porous titanium implants:A review显示文摘One of the biggest challenges in the biocompatibility of implantable metals is the prevention of the stress shielding effect,which is related to the coupling of the bone-metal mechanical properties.This stress shielding phenomenon provokes bone resorption and the consequent adverse effects on prosthesis fixation.However,it can be inhibited by adapting the stiffness of the implant material.Since the use of titanium(Ti)porous structures is a great alternative not only to inhibit this effect but also to improve the osteointegration of orthopedic and dental implants,a brief description of the techniques used for their manufacturing and a review of the current commercialized implants produced from porous Ti assemblies are compiled in this work.As powder metallurgy(PM)with space holder(SH)is a powerful technology used to produce porous Ti structures,it is here discussed its potential for the fabrication of medical devices from the perspectives of both design and manufacture.The most important parameters of the technique such as the size and shape of the initial metallic particles,the SH and binder type of materials,the compaction pressure of the green form,and in the sintering stage,the temperature,atmosphere,and time are reviewed according to the bibliography reported.Furthermore,the importance of the porosity and its types together with the influence of the mentioned parameters in the final porosity and,consequently,in the ultimate mechanical properties of the structure are discussed.Finally,a few examples of the PM-SH application for the manufacturing of orthopedic implants are presented. | Alejandra Rodriguez-Contreras Miquel Punset JoséA.Calero Francisco Javier Gil Elisa Ruperez JoséMaría Manero | 2021 | Journal of Materials Science & Technology2021，，17： | 4 |
| 6 | On the use Zadeh's probabilistic definition for testing statistical hypotheses from fuzzy information显示文摘 | Casals M R Gil M A Gil P | 1986 | Fuzzy Sets and Systems1986，20，： | 4 |
| 7 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 8 | Suitability of aqueous chlorine dioxide versus sodium hypochlorite as an effective sanitizer for preserving quality of fresh-cut lettuce while avoiding by-product formation显示文摘 | Francisco López-Gálvez Ana Allende Pilar Truchado Ascensión Martínez-Sánchez Juan A. Tudela María V. Selma María I. Gil | 2009 | Postharvest Biology and Technology2009，，1： | 2 |
| 9 | Source origin of trace elements in PM from regional background, urban and industrial sites of Spain显示文摘 | X. Querol M. Viana A. Alastuey F. Amato T. Moreno S. Castillo J. Pey J. de la Rosa A. Sánchez de la Campa B. Artí?ano P. Salvador S. García Dos Santos R. Fernández-Patier S. Moreno-Grau L. Negral M.C. Minguillón E. Monfort J.I. Gil A. Inza L.A. Ortega J.M | 2007 | Atmospheric Environment2007，，34： | 2 |
| 10 | Influence of age in estimating maximal oxygen uptake显示文摘ObjectiveTo 在最大的氧举起的估计( EE )的错误上估计年龄的影响( VO 2最大)用性别和在自从估计,测试的周期测力计锻练特定方程的人口, VO 2最大与实质的 EE 被联系,经常超过20%, 18~91 年,可能,由于机械 efficiency.Methods1850 的内在的可变性,成年人(68%人)经历了最大的周期测力计测试的心肺的锻练。心和肺的健康(CRF ) 相对性别和年龄被估计[更年轻(18 ~ 35 年) ,中年(36 ~ 60 年) 并且更旧(>60 年)] 。VO 2 最大[mL·(kg· min )−1] 被对煤气的交换的评价直接测量并且估计了使用性别和人口特定方程。VO 2 最大和相关 EE 在三年龄特定、性特定的 groups.ResultsDirectly 测量的 VO 2 男人和女人的最大是 29.5 ±10.5 mL·(kg· min )−1 和 24.2 ±9.0 mL·(kg· min )−1(P <0.01 ) 。EE [mL·(kg· min ) 为男人和女人的 −1] 和百分比错误(% E ) 有类似的价值, 0.5 ±3.2 和 0.4 ±2.9 mL·(kg· min )−1, 和 − 0.8 ±13.1% 并且 − 1.7 ±15.4%(P >0.05 ) 分别地。分别地,为每个年龄组的 EE 和 % E 为男人:更年轻的 = 1.9 ±4.1 mL·(kg· min )−1 和 3.8 ±10.5% ,中年的 = 0.6 ±3.1 mL·(kg· min )−1 和 0.4 ±10.3% ,更旧的 =− 0.2 ±2.7 mL·(kg· min )−1 和 − 4.2 ±16.6%(P <0.01 ) ;并且为女人:更年轻的 = 1.2 ±3.1 mL·(kg· min )−1 和 2.7 ±10.0% ,中年的 = 0.7 ±2.8 mL·(kg· min )−1 和 0.5 ±11.1% ,更旧的 =-0.8 ±2.3 mL·(kg· min )−1 和 − 9.5 ±22.4%(P <0.01 ).ConclusionVO 2 最大在更年轻的年龄组被低估并且在老年组被过高估计。年龄显著地影响 VO 2 在男人和女人的最大并且当 CRF 用人口被估计时,应该被认为特定方程,而非直接测量了。 | Christina G de Souza Silva Barry A Franklin Daniel E Forman Claudio Gil S Araujo | 2016 | Journal of Geriatric Cardiology2016，13，2： | 2 |
| 11 | Resistance to Corrosion of galvanized steel covered with an epoxy-poly-amideprimer coating 显示文摘 | Gonzalez S Gil M A Hernandez J O | 2001 | ProgressinOrganicCoatings2001，41，： | 1 |
| 12 | Effect of the addition of palladium on grain growth kinetics of pure titanium显示文摘 | Gil F J Picas J A Manero J M | 1997 | J Alloys Compd1997，260，： | 1 |
| 13 | Quinoline resistance associated polymorphisms in the pfcrt, pfmdrl and pfmrp genes of Plasmodium falciparum in Iran 显示文摘 | Ursing JS Zakeri JP Gil A Bjorkman | 2006 | Acta Trop2006，97，： | 1 |
| 14 | Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing 显示文摘 | Gil M I Francisco A Barberan T | 2000 | J Agric Food Chem2000，48，： | 1 |
| 15 | Shallow gas features in incised valley fills ( Ria de Vigo, NW Spain ) : A case study 显示文摘 | Garcia Gil S Vilas F Garcia Garcia A | 2002 | Continental Shelf Research2002，22，： | 1 |
| 16 | Isolation and characterization of abscisic acid-deficient Arabidopsis mutants at two new loci显示文摘 | Leon-Kloosterziel K M Gil M A Ruijs G J | 1996 | Plant J1996，10，： | 1 |
| 17 | Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits显示文摘 | Quiles JL Mesa MD Ramírez-Tortosa CL Aguilera CM Battino M Gil A | 2002 | Arterioscler Thromb Vasc Biol2002，22，7： | 1 |
| 18 | Biomarkers as biological indicators of xeno- biotic exposure 显示文摘 | Gil F Pla A | 2001 | J Appl Toxicol2001，21，： | 1 |
| 19 | New developments in low-doseinsemination technology 显示文摘 | Vazquez J M Roca J Gil M A | 2008 | Theriogenology2008，70，： | 1 |
| 20 | Effect of the volume of medium and number of oocytes during in vitro fertilization on embryo development in pigs 显示文摘 | Gil M A Abeydeera L R Day B N | 2003 | Theriogenology2003，60，76： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员