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| 1 | Bone Regeneration Based on Tissue Engineering Conceptions – A 21st Century Perspective显示文摘The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades.Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction.However,improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity.Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone.Specifically,novel bioactive(second generation)biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment,whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue.Future generations of biomaterials(third generation)are designed to be not only osteoconductive but also osteoinductive,i.e.to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications.These techniques will lead to novel possibilities for tissue regeneration and repair.At present,tissue engineered constructs that may find future use as bone grafts for complex skeletal defects,whether from post-traumatic,degenerative,neoplastic or congenital/developmental'origin'require osseous reconstruction to ensure structural and functional integrity.Engineering functional bone using combinations of cells,scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties.This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts. | Jan Henkel Maria A.Woodruff Devakara R.Epari Roland Steck Vaida Glatt Ian C.Dickinson Peter F.M.Choong Michael A.Schuetz Dietmar W.Hutmacher | 2013 | Bone Research2013，1，3： | 33 |
| 2 | A rat model of bone cancer pain显示文摘 | S.J Medhurst K Walker M Bowes B.L Kidd M Glatt M Muller M Hattenberger J Vaxelaire T O’Reilly G Wotherspoon J Winter J Green L Urban | 2002 | Pain2002，，： | 2 |
| 3 | 16 S rRNA survey revealed complex bacterial communities and evidence of bacterial interference on human adenoids显示文摘 | Tiantian Ren Dominique Ulrike Glatt Tam Nhu Nguyen Emma Kaitlynn Allen Stephen V. Early Michele Sale Birgit Winther Martin Wu | 2012 | Environ Microbiol2012，，2： | 2 |
| 4 | Refinement of the SRS-22health-related quality of life questionnaire function domain显示文摘 | Asher MA Lai SM Glattes RC | 2006 | Spine(Phila Pa 1976)2006，31，： | 1 |
| 5 | Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH-diaphorase显示文摘 | Bredit D S Glatt C E Hwang P M | 1991 | Neruon1991，7，： | 1 |
| 6 | Carbon monoxide: a putative neural messenger 显示文摘 | Verma A Hirsch D J Glatt C E | 1993 | Science1993，259，： | 1 |
| 7 | Placement of coronary stents in bifurcation lesions by the 'Culotte' technique显示文摘 | Chevalier B Glatt B Royer T | 1998 | Am J Cardiol1998，82，8： | 1 |
| 8 | BDNF val66met polymorphism,white matter abnormalities and remission of geriatric depression显示文摘 | Alexopoulos GS Glatt CE Hoptman MJ | 2010 | J Affect Disord2010，125，： | 1 |
| 9 | Underlying characteristics of patients harboring highly resistant Acinetobacter baumannii显示文摘 | MAHGOUB S AHMED J GLATT A E | 2002 | Am J Infect Corntrol2002，30，7： | 1 |
| 10 | A genetic variant BDNF polymorphism aters extinction learning in both mouse and human 显示文摘 | Soliman F Glatt CE Kevin G | 2010 | Science2010，327，5967： | 1 |
| 11 | Meta-analyses sug- gest association between COMT, but not HTR1B, alleles, and suicidal behavior显示文摘 | Kia-Keating B M Glatt S J Tsuang M T | 2007 | Am J Med Genet B Neuropsychiatr Genet2007，144，： | 1 |
| 12 | The prevalence of increased proximal junctional flexion following posterior instrumentation and arthrodesis for adolescent idiopathic scoliosis显示文摘 | Hollenbeck SM Glattes RC Asher MA | 2008 | Spine2008，33，15： | 1 |
| 13 | Experimental subretinal hemorrhage in rabbits显示文摘 | Glatt H Machemer R | 1982 | Am J Ophthalmol1982，94，： | 1 |
| 14 | Meta-analysis of association between the T102C polymorphism of the 5HT2α receptor gene and schizophrenia 显示文摘 | Faraone SV Glatt SJ | 2004 | Schizophr Res2004，67，： | 1 |
| 15 | Evaluation of calcium sulfate paste for augmentation of lumbar pediele screw pullout strength显示文摘 | Schwalm D Glattes RC | 2002 | Spine J2002，2，4： | 1 |
| 16 | High brain densities of the immunophilin FKBP colocalized with calcineurin显示文摘 | Steiner JP Dawson MF Glatt CE | 1992 | Nature1992，358，： | 1 |
| 17 | 16S rRNA survey revealed complex bacterial communities and evidence of bacterial interference on human adenoids显示文摘 | Ren T Glatt DU Nguyen TN | 2013 | Environmental Microbiology2013，15，2： | 1 |
| 18 | Proximal junctional kyphosis in adult spinal deformity following long instrumented posterior spinal fusion:incidence,outcomes,and risk factor analysis显示文摘 | Glattes RC Bridwell KH Lenke LG | 2005 | Spine2005，30，14： | 1 |
| 19 | BDNF val66met polymorphism,white matter abnormalities and remission of geriatric depression显示文摘 | Alexopoulos GS Glatt CE Hoptman MJ | | 0，，： | 1 |
| 20 | Skin-sparing mastectomy and immediate reconstruction is an acceptable treatment option for patients with high-risk breast carcinoma 显示文摘 | Downes K J Glatt B S Kanchwala S K | 2005 | Cancer2005，103，5： | 1 |
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