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| 1 | 世界胃肠病学组织全球指南——发展中国家幽门螺杆菌感染显示文摘世界上有一半人口感染幽门螺杆菌(H.pylori),其感染率因地理位置、种族、年龄和社会经济状况不同而存在很大差异.在发展中国家较高.发达国家较低。但总体而言,近年世界许多地区的H.pylori感染率均呈下降趋势。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F van der Merwe S Vaz Coelho LG Fock M Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BCY Krabshuis J Le Mair A 杜颖 戴宁 | 2011 | 胃肠病学2011，16，7： | 27 |
| 2 | Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg^(+)/HBeAg^(-) mothers显示文摘Vertically transmitted hepatitis B virus(HBV)usually causes chronic infection.While combined active–passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive(HBsAg1)mothers at birth prevents vertical transmission,it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen(HBeAg).This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg1/HBeAg2 mothers.Blood was collected from 46 HBsAg1 mothers and their neonates(subjects)as well as 24 age-matched controls.All neonates of HBsAg1 mothers received appropriate immunoprophylaxis,and HBsAg and hepatitis B surface antibody(anti-HBs)antibody titers were determined after completion of the vaccination course.Peripheral blood mononuclear cells(PBMCs)from infants at birth,1 and 6 months of age were stimulated with recombinant HBsAg,hepatitis B core antigen(HBcAg)and mitogen,and interferon(IFN)-c concentrations were determined by ELISA.HBsAg-induced production of IL-2,IL-5,IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination.All neonates were HBsAg2 and responded to vaccination.Increased IFN-c production following HBcAg stimulation was seen in 30.4%of neonates born to HBsAg1/HBeAg2 mothers.Subjects demonstrated significantly higher IL-2 production post-HBsAg stimulation,whereas IL-5,IL-6 and IL-10 cytokine responses were not significantly different.Almost one-third of uninfected neonates developed viral antigen-induced IFN-c production,suggesting that they had been exposed to virions or viral derivatives.This encounter,however,did not impair their T-cell responses to vaccination. | Lemonica Koumbi Antonio Bertoletti Vassiliki Anastasiadou Maria Machaira Winnie Goh Nikolaos G Papadopoulos Dimitris A Kafetzis Vassiliki Papaevangelou | 2010 | Cellular & Molecular Immunology2010，7，6： | 4 |
| 3 | 肺癌全基因组测序显示文摘肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为'下一代测序技术'的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。大多数的NGS技术是基于平台特异性DNA文库进行多重聚合酶链反应(polymerase chain reaction,PCR),从而对目的基因扩增后测序。这种技术适用于高通量测序,可以检测出肿瘤中出现的全部基因组变异。缺点是这种技术需要在时间、实验设备、计算机数据分析、生物信息技术等各方面的大量投入。NGS技术已广泛应用于全基因组、外显子组、转录组和表观基因组的研究中,为肺癌研究和医疗模式带来改变。这项新技术的开展将转变当前对致癌信号通路的认识,可为癌症诊疗提供新的分子靶点。肺癌体细胞突变已有NGS技术的分析报道,但大规模基因组研究仍在进行中。个体化治疗策略将改善那些潜在获益患者的治疗方式,避免'无辜'患者受无效治疗带来的高额费用和不良反应。NGS的组织化、计算机化和生物信息化技术推动了科技的进步,同时,患者知情权和数据发布的相关伦理问题也浮现出来。信号通路中,驱动基因(driver gene)突变和传递基因(passenger gene)突变的区别,需要对测序结果进行细致解读。解读准确与否取决于DNA提取的样本类型、样本处理技术和样本含量。肿瘤异质性也会降低肿瘤基因突变的检测效能。NGS技术将推动对肿瘤基因突变的基础和临床研究,而且,也可应用于单细胞和游离的循环DNA,未来还将用于从体液和肿瘤亚群中获取的DNA样本。如果能进一步降低费用、提高检验速度和精度,NGS技术无疑将会成为肺癌研究的绝佳选择。 | Marissa Daniels Felicia Goh Casey M. Wright Krishna B. Sriram Vandana Relan Belinda E. Clarke Edwina E. Duhig Rayleen V. Bowman Ian A Yang Kwun M. Fong 孙岚 何建行 | 2013 | 国际病理科学与临床杂志2013，33，4： | 2 |
| 4 | New insights into the management of acne: An update from the Global Alliance to Improve Outcomes in Acne Group显示文摘 | Diane Thiboutot Harald Gollnick Vincenzo Bettoli Brigitte Dréno Sewon Kang James J. Leyden Alan R. Shalita Vicente Torres Lozada Diane Berson Andrew Finlay Chee Leok Goh María Isabel Herane Ana Kaminsky Raj Kubba Alison Layton Yoshiki Miyachi Montserrat P | 2009 | Journal of the American Academy of Dermatology2009，，5： | 2 |
| 5 | Three-dimensional analysis of single pile response to lateral soil movements显示文摘 | Pan J L Goh A T C Wong K S | 2002 | International Journal for Numerical and Analytical Methods in Geomechanics2002，，26： | 1 |
| 6 | Recent advances of inorganic fillers in mixed matrix membrane for gas separa- tion显示文摘 | Goh P S Ismail A F Sanip S M etal | 2011 | Separation and Purification Technology2011，81，3： | 1 |
| 7 | A Weighted Measurement Fusion Kalman Filter Implementation for UAV Navigation 显示文摘 | Goh S T Abdelkhalik O Zekavat S A | 2013 | Aerospace Science and Technology2013，28，1： | 1 |
| 8 | Classification of female genitourinary tract fistula: inter- and intra-observer correla- tions显示文摘 | Goh JT Krause HG Browning A | 2009 | J ObstetGynaecol Res2009，35，： | 1 |
| 9 | Novel endoscopic diagnosis for bladder cancer显示文摘 | Lerner SP Goh A | 2015 | Cancer2015，121，2： | 1 |
| 10 | Three-dimensional finite element analyses of passive pile behaviour显示文摘 | Miao L F Goh A T C Wong K S | 2006 | International Journal for Numerical and Analytical Methods in Geomechanics2006，，30： | 1 |
| 11 | A Revised Weighted Sum Decision Model for Robot Select ion显示文摘 | Tung Y C A Cheng C H | 1996 | Computrs & Industrial Engineering1996，30，2： | 1 |
| 12 | Influence of PLIF cage size on lumbar spine stability显示文摘 | Goh JC Wong HK Thambyah A | 2000 | Spine2000，25，1： | 1 |
| 13 | Fiber Bragg grating compression-tuned over 110 nm 显示文摘 | Mokatar M R Goh C S Butler S A | 2003 | Electronics Letters2003，39，6： | 1 |
| 14 | Effects of inhaled corticosteroid on bone turnover in children with bronchial asthma显示文摘 | Chay OM Goh A Lim WH | 1999 | Respirology1999，4，1： | 1 |
| 15 | Contact stresses in the knee joint in deep flexion显示文摘 | THAMBYAH A GOH J C DE S D | 2005 | Med Eng & Phys2005，27，4： | 1 |
| 16 | Commercial software up- grades may significantly alter Peffusion CT parameter values in colorectal cancer 显示文摘 | Goh V Shastry M Engledow A | 2011 | Eur Radiol2011，21，4： | 1 |
| 17 | Three- dimensional analysis of single pile response to lateral soil movements显示文摘 | PAN J L GOH A T C WONG K S | 2002 | International Journal for Numerical and Analytical Methods in Geomechanics2002，26，8： | 1 |
| 18 | Reciprocating Surface Grinding of a Gamma Titanium Aluminide Intermetallic Alloy显示文摘 | Bentley S A Goh N P Aspinwall D K | 2001 | Journal of Materials Processing Technology2001，118，13： | 1 |
| 19 | Pineal yolk sac tumour with a solid pattern:a case report in a Chinese adult man with Down′s syndrome显示文摘 | Tan H W Ty A Goh S G N | 2004 | J Clin Pathol2004，57，： | 1 |
| 20 | A Revised Weighted Sum Decision Model for Robot Seleetion显示文摘 | Goh C H Tung Y C A Cheng C H | 1996 | Computers & Industrial Engineering1996，30，2： | 1 |
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