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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | National trends in resection of the distal pancreas显示文摘AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal pancreatectomy.Utilization of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology codes.In SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code Manual,third edition procedure codes.We analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative resection.RESULTS:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,respectively.Overall,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the study.Resection was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).Mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open groups.Overall complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was utilized.One and two year survival after resection for malignancy were unchanged over the course of the study(ductal adenocarinoma 1-year 63.6% and 2-year 35.1%,P = 0.53;intraductal papillary mucinous neoplasm and nueroendocrine 1-year 90% and 2-year 84%,P = 0.25).The majority of resections were performed in teaching hospitals(77% NIS and 85% NSQIP),but minimally invasive surgery(MIS) was not more likely to be used in teaching hospitals(15% vs 14%,P = 0.26).Hospitals in the top decile for volume were more likely to be teaching hospitals than lower volume deciles(88% vs 43%,P < 0.001),but were no more likely to utilize MIS at resection.Complication rate in teaching and the top decile hospitals was not significantly decreased when compared to non-teaching(15% vs 14%,P = 0.72) and lower volume hospitals(14% vs 15%,P = 0.99).No difference was seen in the median number of lymph nodes and lymph node ratio in N1 disease when compared by year(P = 0.17 and P = 0.96,respectively).CONCLUSION:There appears to be an overall underutilization of laparoscopy for DP.Centralization does not appear to be occurring.Survival and lymph node harvest have not changed. | Armando Rosales-Velderrain Steven P Bowers Ross F Goldberg Tatyan M Clarke Mauricia A Buchanan John A Stauffer Horacio J Asbun | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 3 | Boron adsorption and silicon release by the clay minerals kaolinite, montmorillonite, and illite显示文摘 | Glaubig R A | 1986 | Soil Sci Soc Am J1986，50，14： | 1 |
| 4 | Effects of statin therapy on arrhythmic events and survival in patients with nonischemic dilated cardiomyopathy显示文摘 | Goldberger JJ Subacius H Schaechter A | 2006 | J Am Coll Cardiol2006，48，6： | 1 |
| 5 | Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients显示文摘 | Bedaiwy M A Falcone T Goldberg J M | 2006 | Hum Reprod2006，21，： | 1 |
| 6 | Dynamic tracking of ischemia in the surface electrocardiogram显示文摘 | Shusterman V Goldberg A Sehindler DM | 2007 | J Elec- trocardiol2007，40，6： | 1 |
| 7 | Apical sealing ability of a new glass ionomer root canal sealer显示文摘 | Goldberg F Patrica L DeSilvio A | 1995 | J Endodon1995，21，10： | 1 |
| 8 | Clinical, laboratory, and MRI analysis of cellulite treatment with a unipolar radiofrequency device 显示文摘 | Goldberg DJ Fazeli A Berlin AL | 2008 | Dermatol Surg2008，34，： | 1 |
| 9 | Dual-domain point diffraction interferometer 显示文摘 | Patrick P Naulleau Kenneth A Goldberg | 1999 | Appl Opt1999，38，16： | 1 |
| 10 | Pattern and consequences of interspecific competition in natural communities:a review of field experiments with plants显示文摘 | Goldberg D E Barton A M | 1992 | American Naturalist1992，139，： | 1 |
| 11 | Free vibration of ring- stiffened shells显示文摘 | Garnet H Goldberg M A | 1962 | Grumann Aircraft gngrg Cor Res Dept Mech1962，21，： | 1 |
| 12 | Extreme ultraviolet carrier-frequency shearing interferometry of a lithographic four- mirror optical system显示文摘 | Naulleau P P Goldberg K A Bokor J | 2000 | J Vacuum Science : Technology B: Microelectronics and Nanometer Structures2000，18，6： | 1 |
| 13 | Can peak expiratory flow measurements estimate small airway function in asthmatic children显示文摘 | Goldberg S Springer C Avital A | 2001 | Chest2001，120，2： | 1 |
| 14 | Clonidine premedieation versus placebo:effects on postoperative ag- itation and recovery time in children undergoing strabis- mus surgery显示文摘 | Heinmiller LJ Nelson LB Goldberg MB et a/ | 2013 | J Pediatr Ophthalmol Strabismus2013，50，30： | 1 |
| 15 | Cruise Ships, Pollution, and international law : The United States takes on royal Caribbean Cruise Lines 显示文摘 | Goldberg W A | 2000 | Wisconsin International Law Journal2000，，19： | 1 |
| 16 | Multiscale entropy analysis of complex physiologic time series显示文摘 | Costa M Goldberger A L Peng C K | 2002 | Physical Review Letter2002，89，6： | 1 |
| 17 | Can Peak Expiratory Flow Measurements Estimate Small Airway Function in Asthmatic Children显示文摘 | Goldberg S Springer C Avital A | 2001 | Chest2001，120，2： | 1 |
| 18 | Muhiseale en- tropy analysis of complex physiologic time series 显示文摘 | COSTA M GOLDBERGER A L PENGC K | 2002 | Phys Rev Lett2002，89，06： | 1 |
| 19 | Single-mode operation of a coiled muhimode fiber amplifier 显示文摘 | KOPLOW J P KLINER D A GOLDBERG L | 2000 | Opt Lett2000，25，7： | 1 |
| 20 | A new plasmidic cefotaximase from patients infected with Salmonella typhimurium显示文摘 | Bauernfeind A Casellas J M Goldberg M | 1992 | Infection1992，20，3： | 1 |
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