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| 1 | Routing and Scheduling of Vehicles and Crews 显示文摘 | Bodin L D Golden B L Assad A A Ball M O | 1983 | Computers and Operations Research1983，10，2： | 2 |
| 2 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 3 | Genetic influences on beef longissimus palatability in Charolais-and Limousin-sired steers and heifers显示文摘 | Wulf D M Tatum J D Green R D Morgan J B Golden B L and Smith G C | 1996 | J Anim Sci1996，74，： | 2 |
| 4 | Outcomes of allergy to insect stings in children,with and without venom immunotherapy显示文摘 | Golden D B Kagey-Sobotka A Norman P S | 2004 | N Engl J Med2004，351，7： | 1 |
| 5 | Laboratory-simulated acid-sulfate weathering of basaltic materials:implications for formation of sulfates at meridiani planum and gusev crater,mars显示文摘 | Golden D C Douglas Ming W Richard Morris V | 2005 | Journal of Geophysical Research E Planets2005，110，12： | 1 |
| 6 | Hydrocarbon bond dissociation energies显示文摘 | McMillen D F Golden D M | 1982 | Annu Rev Chem1982，33，： | 1 |
| 7 | Simplified processing for high spectral efficiency wireless communication employing multi-element arrays显示文摘 | Foschini G J Jr G D Golden | 1999 | IEEE J Select Areas Commun1999，17，： | 1 |
| 8 | Cytogenetic damage in blood lymphocytes and exfoliated epithelial cells of children with inflammatory bowel disease 显示文摘 | Holland N Harmatz P Golden D | 2007 | Pediatr Res2007，61，2： | 1 |
| 9 | Potential impacts of clean air regulations on system operations显示文摘 | Le K D Golden J L Stansberry C J | 1995 | IEEE Transactions on Power Systems1995，，： | 1 |
| 10 | Career patterns and job satisfaction of canadian nurses education显示文摘 | Barrett MC Golden berg D Fauxs | 1992 | Journal of Advanced Nursing1992，12，8： | 1 |
| 11 | Nutrient-substituted hydroxyapatites synthesis and characterization 显示文摘 | Golden D C Ming D W | 1999 | Journal of the Soil Science Society of America1999，63，2： | 1 |
| 12 | Simplified processing for high spectral efficiency wireless communication employing multi-element arrays显示文摘 | Foschini G J Golden G D Valenzuela R A | 1999 | IEEE Journal on Selected Areas in Communications1999，17，11： | 1 |
| 13 | The cardiovascular toll of stress显示文摘 | BROTMAN D J GOLDEN S H WITTSTEIN I S | 2007 | Lancet2007，370，： | 1 |
| 14 | 1,4-Cyclohexadiene with Pd/C as a rapid,safe transfer hydrogenation system with microwave heating显示文摘 | QUINN F J RAZZANO A D GOLDEN C K | 2008 | Tetrahedron Lett2008，49，： | 1 |
| 15 | Thermochemistry of Some Six-Membered Cyclic and Polycyclic Compounds Debated to Coal显示文摘 | Shaw R Golden D M Benson S W | 1977 | JPhys Chem1977，81，12： | 1 |
| 16 | Implantation of recombinant human bone morphogenetie proteins with biomaterial carriers: A correlation between protein pharmacokinetics and osteoinduction in the rat ectopic model显示文摘 | Uludag H D'Augusta D Golden J | 2000 | J Biomed Mater Res2000，50，2： | 1 |
| 17 | Prediction Scheme for Thermodynamical Properties of Polycyclic Aromatic Hydroge- nation显示文摘 | Stein S Golden D M Benson S W | 1977 | JPhys Chem1977，81，2： | 1 |
| 18 | The impact of superior - subordi- nate relationships on the commitment,job satisfaction, and performance of virtual workers 显示文摘 | Golden T D Veiga J F | 2008 | Leadership Quarterly2008，19，1： | 1 |
| 19 | Detection algorithm and initial laboratory results using V-BLAST space-time communication architecture 显示文摘 | GOLDEN G D FOSCHINI G J VALENZUELA R A | 1999 | Electronics Letters1999，35，1： | 1 |
| 20 | FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neurons 显示文摘 | Guez-Barber D Fanous S Golden SA | 2011 | J Neurosci2011，31，11： | 1 |
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