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| 1 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 2 | Keratoconus in a patient with Alport syndrome: A case report显示文摘BACKGROUND Known ocular manifestations of Alport syndrome include features such as anterior lenticonus and fleck retinopathy. Reports of keratoconus in such patients are limited. We report tomographic findings consistent with keratoconus in a patient with Alport syndrome.CASE SUMMARY A 52-year-old female was referred to our ophthalmology clinic with decreased vision and increased tearing. She was diagnosed with stage Ⅲ Alport syndrome two years prior. Upon examination she was found to have average keratometries of 48D bilaterally with tomographic evidence of keratoconus.CONCLUSION Although a rare presentation, concurrent Alport syndrome and keratoconus should be considered when reviewing the ocular health of Alport syndrome patients and appropriate management steps should be taken upon the diagnosis. | Majid Moshirfar David F Skanchy Aaron T Gomez Yasmyne C Ronquillo Benjamin Buckner Phillip C Hoopes | 2019 | World Journal of Clinical Cases2019，7，19： | 2 |
| 3 | Pericytes synthesize renin显示文摘AIM: To investigate renin expression in pericytes during normal kidney development and after deletion of angiotensinogen, the precursor for all angiotensins.METHODS: We examined the distribution of renin expressing cells by immunoshistochemistry in the interstitial compartment of wild type(WT) and angiotensinogen deficient(AGT-/-) mice at different developmental stages from embryonic day 18(E18: WT, n = 4; AGT-/-, n = 5) and at day 1(P1: WT, n = 5; AGT-/-, n = 5), 5(P5: WT, n = 7; AGT-/-, n = 8), 10(P10: WT, n = 3; AGT-/-, n = 5), 21(P21: WT, n = 7; AGT-/-, n = 5), 45(P45: WT, n = 3; AGT-/-, n = 3), and 70(P70: WT, n = 2; AGT-/-, n = 2) of postnatal life. We quantified the number of pericytes positive for renin at all the developmental stages mentioned above and comparedthe results of AGT-/- mice to their WT counterparts.RESULTS: In WT mice, renal interstitial pericytes synthesize renin in early life supporting a lineage relationship with renin cells in the vasculature. The number of pericytes positive for renin per area of 0.32 mm2(density) in WT mice was maintained from fetal life till weaning age(E18 = 4.25 ± 0.63, P1 = 3.75 ± 0.48, P5 = 3.75 ± 0.48, P10 = 4 ± 0.71, P21 = 3.8 ± 0.58) and markedly decreased in adult life(P45 = 1.2 ± 0.37, P70 = 0.8 ± 0.20). On the other hand, in AGT-/- mice the density of pericytes expressing renin was not significantly different from WT mice at E18 and P1: E18 = 5.75 ± 0.50 vs 4.25 ± 0.63(P = 0.106), P1 = 9.25 ± 3.50 vs 3.75 ± 0.48(P = 0.175) but significantly increased from P5 till P70: P5 = 38.25 ± 5 vs 3.75 ± 0.48(P = 0.0004), P10 = 173 ± 7.50 vs 4 ± 0.70(P = 5.24567 × 10-7), P21 = 83 ± 6.70 vs 3.8 ± 0.58(P = 2.97358 × 10-6), P45 = 49 ± 3.50 vs 1.2 ± 0.37(P = 8.18274 x 10-7) and P70 = 17.8 ± 2.30 vs 0.8 ± 0.20(P = 3.51151 × 10-5). The AGT-/- mice showed a marked increase in the number of pericytes per field studied starting from P5, reaching its peak at P10, and then a gradually decreasing until P70. CONCLUSION: Interstitial pericytes synthesize renin during development and the number of renin-expressing pericytes increases in response to a homeostatic threat imposed early in life such as lack of angiotensinogen. | Alison C Berg Catalina Chernavvsky-Sequeira Jennifer Lindsey R Ariel Gomez Maria Luisa S Sequeira-Lopez | 2013 | World Journal of Nephrology2013，2，1： | 2 |
| 4 | Completely autotrophic nitrogen removal over nitrite in one single reactor 显示文摘 | Sliekers A O Derworth N Gomez J L C | 2002 | Water Research2002，36，： | 1 |
| 5 | Slow pyrolysis of woody residues and an herbaceous biomass crop:a kinetic study显示文摘 | GOMEZ C J VARHEGYI G PUIGJANER L | 2005 | Industrial and Engineering Chemistry Research2005，44，17： | 1 |
| 6 | Stereotactic biopsy for brainstem tumors in pediatric patients 显示文摘 | PEREZ GOMEZ J L RODRIGUEZ ALVAREZ C A MARHX BRACHO A | 2010 | Childs Nerv Syst2010，26，1： | 1 |
| 7 | Damage mechanics constitutive model for Pb/Sn solder joints incorporating nonlinear kinematic hardening and rate dependent effects using a return mapping integration algorithm显示文摘 | Gomez J Basaran C | 2006 | Mechanics of Materials2006，38，： | 1 |
| 8 | Expression of immunogenic glycoprotein S polypeptides from transmissible gastroenteritis coronavirus in transgenic plants 显示文摘 | Gomez N Carrillo C Salinas J | 1998 | Virplogy1998，249，： | 1 |
| 9 | Structure of diamond-like carbon films containing transition metals deposied by reactive magnetron sputtering 显示文摘 | Corbella C Oncins G Gomez M A | 2005 | Diamond & Related Meterials2005，14，： | 1 |
| 10 | Development of volatile compounds during fruit maturation:xharacterization of apricot and plum×apricot hybrids显示文摘 | GOMEZ E LEDBTTER C A | 1997 | J Sci Food Agric1997，74，： | 1 |
| 11 | Dementia in Parkinson disease: a proton magnetic resonance specroscpy study显示文摘 | Summerfield C Gomez Anson B Tolosa E | 2002 | Arch Neurol2002，59，9： | 1 |
| 12 | Geochemical indicators of intrinsic bioremediafion 显示文摘 | Borden R C Gomez C A and Beeker M T | 1995 | Ground Water1995，33，2： | 1 |
| 13 | Water exchanges versus water works: Insights from a computable general equilibrium model for the Balearic Islands显示文摘 | GOMEZ C M TIRADO D REY-MAQUIEIRA J | 2004 | Water Resources Research2004，40，： | 1 |
| 14 | Influence of dietary n - 3HUFA Ievels on juvenile gilthead sea- bream (Sparus aurata ) growth and tissue fatty acid composition 显示文摘 | Ibeas C Cejas J R Gomez t T | 1996 | Aquaculture1996，，142： | 1 |
| 15 | Induction of gynogenesis in the turbot (Scophthalmus maximus) : Effects of UV irradiation on sperm motility, the Hertwig effect and viability during the first 6 months of age 显示文摘 | Piferrer F Cal R M Gomez C | 2004 | Aquaculture2004，238，14： | 1 |
| 16 | Efficacy of pulmonary rehabilitation in patients with moderate chronic obstructive pulmonary disease: a ran- domized controlled trial显示文摘 | Roman M Larraz C Gomez A | 2013 | BMC Fam Pract2013，14，： | 1 |
| 17 | Gas dispersion measurements in flotation cells 显示文摘 | GOMEZ C O FINCH J A | 2007 | International Journal of Mineral Processing2007，84，： | 1 |
| 18 | Male breast cancer显示文摘 | GOMEZ RAPOSO C ZAMBRANA TfiVAR F SERENO MOYA-NO M | 2010 | Cancer Treat Rev2010，36，6： | 1 |
| 19 | Pendimethalin and oxyfluorfen degradation under two irrigation conditions over four years application 显示文摘 | Alister C A Gomez P A Rojas S | 2009 | Journal of Environment Science Health B2009，44，： | 1 |
| 20 | Interferongamma production by neutrophils during bacterial pneumonia in mice显示文摘 | Yamada M Gomez J C Chugh P E | 2011 | Am J Respir Crit Care Med2011，183，10： | 1 |
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