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| 1 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Maltotriose utilization by industrial Saccharomyces strains: characterization of a new member of the a-glucoside transporter family显示文摘 | SALEMA-OOM M VALADAO PINTO V GONCALVES P | 2005 | Appl Environ Microbiol2005，71，： | 1 |
| 4 | Purification of metallurgical grade silicon by acid leaching显示文摘 | SANTOS I C GONCALVES A P SANTOS C S ALMEIDA M AFONSO M H CRUZ M J | 1990 | Hydrometallurgy1990，23，： | 1 |
| 5 | Quality changes of deepwater pink shrimp (parapenaeus longirostris) packed in mod- ified atmosphere显示文摘 | Goncalves A C Lopez-caballero M E Nunes M L | 2003 | Journal of Food Science2003，68，8： | 1 |
| 6 | Usefulness of mean platelet volume as a biomarker for long-term outcomes after percutaneous coronary intervention显示文摘 | Goncalves SC Labinaz M Le May M | 2011 | Am J Cardiol2011，107，： | 1 |
| 7 | Pesticide toxicity assessment using an electrochemical biosensor with Pseudomonas putida and a bioluminescence inhibition assay with Vibrio fischeri显示文摘 | Goncalves C Lacorte S | 2002 | Anal Bioanal Chem2002，373，： | 1 |
| 8 | On the growth and electrical characterization of CuO nanowires by thermal oxidation显示文摘 | Goncalves A M B Campos L C Ferlaut A S | 2009 | J Appl Phys2009，106，03： | 1 |
| 9 | Solvent recovery from soybean oil/hexane mis- celia by polymeric membranes 显示文摘 | RIBEIRO A P B DE MOUR J M L N GONCALVES L A G | 2006 | Journal of Membrane Science2006，282，12： | 1 |
| 10 | A method for the evaluation of the fatigue operational life of submarine pressure hulls 显示文摘 | Robles L B R Buelta M A Goncalves E | 2000 | International Journal of Fatigue2000，22，： | 1 |
| 11 | Biology of two parasitoids of leafminers Liriomyza spp,Diglyphus isaea and Dpoppoea,in southern Portugal显示文摘 | GONCALVES M A ALMEIDA L | 2005 | Journal of Food Agriculture & Environment2005，3，2： | 1 |
| 12 | Sulfate reduction in acidogenic phase anaerobic-digestion 显示文摘 | REIS M A M GONCALVES L M D CARRONDO M J T | 1988 | Water Science and Technology1988，20，1112： | 1 |
| 13 | The effects of SiCp clusters and porosity on the mechanical properties of PM Al matrix composites显示文摘 | GONCALVES M GOLDENSTEIN H | 1997 | Key Engineering Materials1997，，： | 1 |
| 14 | Efficient gene ration and amplification of high-capacity adeno-associated virus Padenovirus hybrid vectors显示文摘 | Goncalves M A vander Velde I Janssen J M | 2002 | J Virol2002，76，10： | 1 |
| 15 | Asymmetric polysulfone and polyethersulfone membranes: effects of thermodynamic conditions during formation on their performance 显示文摘 | Barth C Goncalves M C Pires A T N | 2000 | J Membr Sci2000，169，2： | 1 |
| 16 | The expression in Saccharomyces cerevisiae of a glucose/xylose symporter from Candida intermedia is affected by the presence of a glucose/ xyose facilitor 显示文摘 | Leandro M J Spencer-Martins I Goncalves P | 2008 | Microbiology2008，154，： | 1 |
| 17 | Fatal infection due to Haemophilus parasuis in a young wild boar (Sus scrofa)显示文摘 | Cuesta Gerveno J M Risco Perez D Goncalves Blanco P | 2013 | J Vet Diagn Invest2013，25，2： | 1 |
| 18 | A genetic algorithm for the resource constrained multi-project scheduling problem显示文摘 | Goncalves J F Mendes J J M Resende M G C | 2008 | European Journal of Operational Research2008，189，3： | 1 |
| 19 | Effect of preparation conditions on morphology,drug contentand release profiles of poly(hydroxybutyrate)microparticlescontaining piroxicam显示文摘 | Bazzo G C Lemos-Senna E Goncalves M C Pires A T N | 2008 | J Brazil Chem Soc2008，19，5： | 1 |
| 20 | Hexose and pentose transport in ascomycetous yeasts:an overview显示文摘 | Leandro M J Fonseca C Goncalves P | | 0，，04： | 1 |
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