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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | A noise optimization technique for integrated low-noise amplifiers显示文摘 | Goo J S Ahn H T Ladwig D J | 2002 | Journal of Solid-state Circuits IEEE2002，37，8： | 1 |
| 3 | The African catfish,Clarias gariepinus,a model for the study of reproductive endocrinologyin teleosts显示文摘 | VAN OORDT P G W J GOOS H J Th | 1987 | Aquaculture1987，63，： | 1 |
| 4 | Temperature related study on PEM fuel cell显示文摘 | KIM J GOO Y JANG H R | 2004 | Science and Technology2004，1，： | 1 |
| 5 | The regulation of gonadotropin release by neurohormones and gonadal steroids in the African catfish, Clarias gariepinus 显示文摘 | De Leeuw R Goos H J Th Van Oordt P G W J | 1987 | Aquaculture1987，63，14： | 1 |
| 6 | CT of congenital heart disease: normal anatomy and typical pathologic conditions 显示文摘 | GOO H W PARK I S KO J K etal | 2003 | Radiographics2003，23，： | 1 |
| 7 | False positive and false negative FDG PET scans in various thoracic diseases显示文摘 | Chang JM Lee H J Goo J M | 2006 | Korean J Radiol2006，7，1： | 1 |
| 8 | Bronchial anthracofibrosis (inflammatory bronchial stenosis with anthracotic pigmentation): CT findings显示文摘 | KIM H Y IM J G GOO J M | 2000 | Am J Roentgenol2000，174，： | 1 |
| 9 | Pulmonary alveolar proteinosis versus exogenous lipoid pneumonia showing crazy-paving pattern: Comparison of their clinical features and high-resolution CT findings显示文摘 | CHOI H K PARK C M GOO J M | 2010 | Acta Radiol2010，51，4： | 1 |
| 10 | The Initial Stages of Template-Controlled CaCo3 Formation Revealed by Ctyo-TEM显示文摘 | Pouget E M Bnmans P H H Goos J A C M | 2009 | Science2009，323，5920： | 1 |
| 11 | The effect of pimozide-LHRHa and 17α-hydroxyprogesterone on plasma steroids and ovulation in the African catfish,Clarias gariepinus显示文摘 | RICHTER C J J EDING E H GOOS H J Th | 1987 | Aquaculture1987，63，： | 1 |
| 12 | The role of service level agreements in relational management of information technology outsourcing: An empirical study显示文摘 | Goo J Kishore R Rao H R | 2009 | MISQuarterly2009，38，1： | 1 |
| 13 | A noise optimization technique for integrated low noise amplifiers显示文摘 | GOO J S AHN H T LADWIG D J | 2002 | IEEE J Solid-State Circuits2002，37，8： | 1 |
| 14 | A noise optimization technique for integrated low -noise amplifiers显示文摘 | GOO J S AHN H T DONALD L | 2002 | IEEE Journal of Solid-State Circuits2002，37，8： | 1 |
| 15 | Mechanism of rapid degradation of nanostructured Mg2 Ni hydrogen storage alloy electrode synthesized by mechanical alloying and the effect of mechanically coating with nickel 显示文摘 | Goo N H Woo J H Lee K S | 1999 | J Alloys Comp1999，288，： | 1 |
| 16 | Pulmonary Blastoma:Radiologic Findings in Five Pationts显示文摘 | LEE H J GOO J M KIM KW | 2004 | Clin-Imaging2004，28，2： | 1 |
| 17 | Systemic arterial supply to the lungs in adults:spiral CT findings显示文摘 | Do K H Goo J M Im J G | 2001 | Radiographics2001，21，2： | 1 |
| 18 | Temperature related study on PEM fuel cell显示文摘 | KIM J GOO Y JANG H R | 2004 | Science and Technology2004，，1： | 1 |
| 19 | Correlation between the size of the solid component on thin-section CT and the invasive component on pathology in small lung adenocarci- nomas manifesting as ground-glass nodules 显示文摘 | Lee K H Goo J M Park S J | 2014 | J Thorac Oncol2014，9，1： | 1 |
| 20 | The role of service level agreements in relational management of information technology out- sourcing: an empirical study 显示文摘 | GOO J KISHORE R RAO H R | 2009 | Mis Quarterly2009，33，1： | 1 |
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