|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intestinal permeability and its association with the patient and disease characteristics in Crohn's disease显示文摘AIM:To assess the intestinal permeability (IP) in patients with Crohn's disease (CD) and study the association of IP with the patient and disease characteristics. METHODS: One hundred and twenty five consecutive patients of CD (Males: 66) were diagnosed on the basis of a combination of standard clinical, endoscopic, imaging and histological features. CD activity index (CDAI) was used to calculate the activity of the disease while the behavior of the disease was assessed by the modified Montreal classification. IP was measured by the ratio of the percentage excretion of ingested doses of lactulose and mannitol in urine (LMR). The upper limit of normality of LMR (0.037) was derived from 22 healthy controls. RESULTS: Thirty six percent of patients with CD had increased IP. There was no significant difference in mannitol excretion (patients vs controls = 12.5% vs 14.2%, P = 0.4652), but lactulose excretion was significantly higher in patients compared to healthy controls (patients vs controls = 0.326% vs 0.293%, P = 0.0391). The mean LMR was also significantly higher in the patients as compared to healthy controls [0.027 (0.0029-0.278) vs 0.0164 (0.0018-0.0548), P = 0.0044]. Male patients had a higher LMR compared to females [0.036 (95% CI 0.029, 0.046) vs 0.022 (95% CI 0.0178, 0.028) (P = 0.0024), though there was no difference in the number of patients with abnormal IP in boththe sexes. Patients with an ileo-colonic disease had a higher LMR than those with only colonic disease [0.045 (95% CI 0.033, 0.06) vs 0.021 (95% CI 0.017, 0.025) (P < 0.001)]. Of patients with ileo-colonic disease, 57.8% had an abnormal IP, compared to 26.7% with colonic and 15.6% with small intestinal disease. Patients with a stricturing disease had significantly higher LMR compared to non-fistulising non-stricturing disease [0.043 (95% CI 0.032, 0.058) vs 0.024 (95% CI 0.019, 0.029) (P = 0.0062)]. There was no correlation of IP with age, disease activity, duration of illness, D-xylose absorption, upper GI involvement, perianal disease, and extra- intestinal manifestations. On multiple regression analysis, male gender and ileo-colonic disease were independent factors associated with increased IP. Gender, location, behavior of the disease and upper GI involvement could explain up to 23% of variability in IP (R2 = 0.23). CONCLUSION: IP was increased in 36% of patients with CD. Male gender and an ileo-colonic disease were the independent factors associated with increased IP. | Jaya Benjamin Govind K Makharia Vineet Ahuja Mani Kalaivan Yogendra K Joshi | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 2 | Recommendations to quantify villous atrophy in video capsule endoscopy images of celiac disease patients显示文摘AIM To quantify the presence of villous atrophy in endoscopic images for improved automation.METHODS There are two main categories of quantitative descriptors helpful to detect villous atrophy:(1) Statistical and(2) Syntactic. Statistical descriptors measure the small intestinal substrate in endoscope-acquired images based on mathematical methods. Texture is the most commonly used statistical descriptor to quantify villous atrophy. Syntactic descriptors comprise a syntax, or set of rules, for analyzing and parsing the substrate into a set of objects with boundaries. The syntax is designed to identify and distinguish three-dimensional structures based on their shape.RESULTS The variance texture statistical descriptor is useful to describe the average variability in image gray level representing villous atrophy, but does not determine the range in variability and the spatial relationships between regions. Improved textural descriptors will incorporate these factors, so that areas with variability gradients and regions that are orientation dependent can be distinguished. The protrusion syntactic descriptor is useful to detect three-dimensional architectural components, but is limited to identifying objects of a certain shape. Improvement in this descriptor will require incorporating flexibility to the prototypical template, so that protrusions of any shape can be detected, measured, and distinguished.CONCLUSION Improved quantitative descriptors of villous atrophy are being developed, which will be useful in detecting subtle, varying patterns of villous atrophy in the small intestinal mucosa of suspected and known celiac disease patients. | Edward J Ciaccio Govind Bhagat Suzanne K Lewis Peter H Green | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，18： | 3 |
| 3 | Implementation of a polling protocol for predicting celiac disease in videocapsule analysis显示文摘AIM: To investigate the presence of small intestinal villous atrophy in celiac disease patients from quantitative analysis of videocapsule image sequences.METHODS: Nine celiac patient data with biopsy-proven villous atrophy and seven control patient data lacking villous atrophy were used for analysis. Celiacs had biopsy-proven disease with scores of Marsh Ⅱ-Ⅲ C except in the case of one hemophiliac patient. At four small intestinal levels (duodenal bulb, distal duodenum, jejunum, and ileum), video clips of length 200 frames (100 s) were analyzed. Twenty-four measurements were used for image characterization. These measurements were determined by quantitatively processing the videocapsule images via techniques for texture analysis, motility estimation, volumetric reconstruction using shape-from-shading principles, and image transformation. Each automated measurement method, or automaton, was polled as to whether or not villous atrophy was present in the small intestine, indicating celiac disease. Each automaton's vote was determined based upon an optimized parameter threshold level, with the threshold levels being determined from prior data. A prediction of villous atrophy was made if it received the majority of votes (≥ 13), while no prediction was made for tie votes (12-12). Thus each set of images was classified as being from either a celiac disease patient or from a control patient. RESULTS: Separated by intestinal level, the overall sensitivity of automata polling for predicting villous atrophy and hence celiac disease was 83.9%, while the specificity was 92.9%, and the overall accuracy of automata-based polling was 88.1%. The method of image transformation yielded the highest sensitivity at 93.8%, while the method of texture analysis using subbands had the highest specificity at 76.0%. Similar results of prediction were observed at all four small intestinal locations, but there were more tie votes at location 4 (ileum). Incorrect prediction which reduced sensitivity occurred for two celiac patients with Marsh type Ⅱ pattern, which is characterized by crypt hyperplasia, but normal villous architecture. Pooled from all levels, there was a mean of 14.31 ± 3.28 automaton votes for celiac vs 9.67 ± 3.31 automaton votes for control when celiac patient data was analyzed (P<0.001). Pooled from all levels, there was a mean of 9.71 ± 2.8128 automaton votes for celiac vs 14.32 ± 2.7931 automaton votes for control when control patient data was analyzed (P<0.001). CONCLUSION: Automata-based polling may be useful to indicate presence of mucosal atrophy, indicative of celiac disease, across the entire small bowel, though this must be confirmed in a larger patient set. Since the method is quantitative and automated, it can potentially eliminate observer bias and enable the detectionof subtle abnormality in patients lacking a clear diagnosis. Our paradigm was found to be more efficacious at proximal small intestinal locations, which may suggest a greater presence and severity of villous atrophy at proximal as compared with distal locations. | Edward J Ciaccio Christina A Tennyson Govind Bhagat Suzanne K Lewis Peter H Green | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 3 |
| 4 | Delineation of a conserved B cell epitope on bonnet monkey (Macaca radiata) and human zona pellucida glycoprotein-B by monoclonal antibodies demonstrating inhibition of sperm-egg binding 显示文摘 | Govind CK Hasegawa A Koyama K | 2000 | Biol Reprod2000，62，1： | 1 |
| 5 | Usefulness of intralesional triamci- nolone in treatment of benign esophageal strictures 显示文摘 | Rakesh K Govind K | 2002 | Gastrointest Endosc2002，56，6： | 1 |
| 6 | Development of rapidly solidified (RS)magnesium-aluminium-zinc alloy显示文摘 | Govind K Suseelan Nair | 2001 | Materials Science and Engineering A2001，，： | 1 |
| 7 | Whole-brain proton MR speetroseopie imaging of mild-to-moderate traumatic brain injury and correlation with neuropsyehological deficits 显示文摘 | Govind V Gold S Kaliannan K | 2010 | J Neurotrauma2010，27，3： | 1 |
| 8 | Small-subunit ribosomal DNA sequence analyses and a reconstruction of the inferred phylogeny among symbiotic dinoflagellates (Pyrrophyta) 显示文摘 | McNally K L Govind N S Thome P E | 1994 | J Phycol1994，30，： | 1 |
| 9 | The nucleotide sequence of the small subunit ribosomal RNA gene from Symbiodinium pilosum, a symbiotic dinoflagellate 显示文摘 | Sadler L A McNally K L Govind N S | 1992 | Curr Genet1992，21，： | 1 |
| 10 | Identification and functional validation of a unique set of drought induced genes preferentially expressed in response to gradual water stress in peanut显示文摘 | Govind G Harshavardhan V T Patricia J K | 2009 | Molec- ular Genetics and Genomics2009，281，： | 1 |
| 11 | Development of rapidly solidified (RS) magnesium-aluminiumzinc alloy 显示文摘 | Govind K Suseelan Nair Mittal M C | 2001 | Materials Science and Engineering A2001，304，： | 1 |
| 12 | Threshold Based Kernel Level HTTP Filter (TBHF) for DDoS Mitigation显示文摘 | Ak M I George L Govind K | 2012 | Interna- tional Journal of Computer Network and Information Security (IJCNIS)2012，4，12： | 1 |
| 13 | Delineation of a conserved B ceil epitope on bonnet monkey (Macaca radiata ) and human zona pellucida glycoprotein-B by monoctonal anti bodies demonstrating inhibition of sperm-egg binding 显示文摘 | Govind C K Hasegawa A Koyama K | 2000 | Bi ology of Reproduction2000，62，1： | 1 |
| 14 | Purified and re folded recombinant bonnet monkey (Maceca radiate ) zona pellucida glycoprotein-B expressed in Escterichia coli binds to spermatozoa 显示文摘 | Govind C K Gahlay G K Choudhury S | 2001 | Biohlgy of Reproduction2001，64，4： | 1 |
| 15 | EPR and optical absorption study of Mn2+-doped zinc ammonium phosphate hexahydrate single crystals显示文摘 | Kripal R Govind H Gupta S K | 2007 | Physica B: Condensed Matter2007，392，12： | 1 |
| 16 | Failure of female baboons (Papio a nubis) to conceive following immunization with recombinant non human primate zone pellucida glycoprotein B expressed in Escherichia coli 显示文摘 | Govind C K Gupta S K | 2000 | Vaccine2000，18，26： | 1 |
| 17 | Identification and functional validation of a unique set of drought induced genes preferentially expressed in response to gradual water stress in peanut 显示文摘 | Govind G ThammeGowda H V Kalaiarasi P J Iyer D R Muthappa S K Nese S Makarlu U K | 2009 | Mol Genet Genomics2009，281，： | 1 |
| 18 | Beneficial effects of S-adenosyl- l-methionine on aminolevulinic acid dehydratase, glutathione, and lipid peroxidation during acute lead: ethanol administration in mice显示文摘 | GOVINDER J S F PRAHLAD K S | 1999 | Alcohol1999，18，2： | 1 |
| 19 | Direct catalytic transformation of carbohydrates into 5-ethoxymethylfurfural with acid-base bifunctional hybrid nanospheres 显示文摘 | HU Li GOVIND K S KOTNI R | 2014 | Energy Conversion and Management2014，88，： | 1 |
| 20 | Development of rapidly solidified (RS) magnesium-aluminium-zinc alloy 显示文摘 | GOVIND SUSEELAN NAIR K MITTAL M C LAL K MAHANTI R K SIVARAMAKRISHNAN C S | 2001 | Mater Sci Eng A2001，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员