|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNAs and liver cancer associated with iron overload:Therapeutic targets unravelled显示文摘Primary liver cancer is a global disease that is on the increase.Hepatocellular carcinoma(HCC)accounts for most primary liver cancers and has a notably low survival rate,largely attributable to late diagnosis,resistance to treatment,tumour recurrence and metastasis.MicroRNAs(miRNAs/miRs)are regulatory RNAs that modulate protein synthesis.miRNAs are involved in several biological and pathological processes including the development and progression of HCC.Given the poor outcomes with current HCC treatments,miRNAs represent an important new target for therapeutic intervention.Several studies have demonstrated their role in HCC development and progression.While many risk factors underlie the development of HCC,one process commonly altered is iron homeostasis.Iron overload occurs in several liver diseases associated with the development of HCC including Hepatitis C infection and the importance of miRNAs in iron homeostasis and hepatic iron overload is well characterised.Aberrant miRNA expression in hepatic fibrosis and injury response have been reported,as have dysregulated miRNA expression patterns affecting cell cycle progression,evasion of apoptosis,invasion and metastasis.In2009,miR-26a delivery was shown to prevent HCC progression,highlighting its therapeutic potential.Several studies have since investigated the clinical potential of other miRNAs with one drug,Miravirsen,currently in phaseⅡclinical trials.miRNAs also have potential as biomarkers for the diagnosis of HCC and to evaluate treatment efficacy.Ongoing studies and clinical trials suggest miRNA-based treatments and diagnostic methods will have novel clinical applications for HCC in the coming years,yielding improved HCC survival rates and patient outcomes. | Catherine M Greene Robert B Varley Matthew W Lawless | 2013 | World Journal of Gastroenterology2013，19，32： | 5 |
| 2 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 3 | Genetic influences on beef longissimus palatability in Charolais-and Limousin-sired steers and heifers显示文摘 | Wulf D M Tatum J D Green R D Morgan J B Golden B L and Smith G C | 1996 | J Anim Sci1996，74，： | 2 |
| 4 | Anassessment of the relationship between chlorophyll fluorescence and CO2 gas exchange from field measurement on a moss and lichen 显示文摘 | GREEN T G A SCHROETER B KAPPEN L | 1998 | Planta1998，206，4： | 2 |
| 5 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 6 | The Career Reasons of Minority Nascent Entrepreneurs 显示文摘 | Canner N M Gartner W B Greene P G | 2003 | Academy of Management Proceeding2003，18，1： | 1 |
| 7 | Forensic classification of ballpoint pen inks using high performance liquid chromatography and infrared spectroscopy with principal components analysis and linear discriminant analysis显示文摘 | KHER A MULHOLLAND M GREEN E REEDY B | 2006 | Vib Spectros2006，40，2： | 1 |
| 8 | Characterization of the bovine pregnancy-associated glycoprotcin gone family-analysisof gene sequences, regulatory regions within the promoter and expression of selected genes 显示文摘 | Telugu B P Walker A M Green J A et el | 2009 | BMC Genomics2009，10，： | 1 |
| 9 | Semi-analytical dynamic analysis of spiral-grooved mechanical gas face seals显示文摘 | Miller B A Green I | 2003 | Iournal of Tribology2003，125，： | 1 |
| 10 | Heat shock protein70 inhibits apoptosis by preven - ring recruitment of procaspase - 9 to the Apf - 1 apoptosome显示文摘 | Becre H M Wolf B B Green D R | 2000 | Nat Cell Biol2000，2，： | 1 |
| 11 | Effect of using Threadrin Shad as forage for channel catfish fed daily or every third day 显示文摘 | Green B Perschbacher P Ludwing G | 2009 | N Am J Aquacult2009，71，1： | 1 |
| 12 | Use of ozone in the food industry显示文摘 | Zeynep B Guzel-Seydim Annel K Greene A C Seydim | 2004 | Lebensm-Wissu-Technol2004，37，： | 1 |
| 13 | Carbon fiber-reinforced polymer wraps for corrosion control and rehabilitation of reinforced concrete columns显示文摘 | DEBAIKY A S GREEN M F HOPE B B | 2002 | ACI Materials Journal2002，99，2： | 1 |
| 14 | Early analgesia for children with acute abdam inal pain 显示文摘 | Green R Bulloch B Kabani A | 2005 | Pediatrics2005，116，4： | 1 |
| 15 | The effects of Xylazine and fentanyl on various hormones and motabolites in karakul sheep and blesbok显示文摘 | Maraisal A L Greene S A Wei A B | 1991 | J S Afr Vet Assoc1991，62，1： | 1 |
| 16 | Destruction or decomposition of hypergolic chemicals in a liquid propellant testing laboratory 显示文摘 | Greene B McClure MB Harry T | 2004 | Chemical Health and Safety2004，11，1： | 1 |
| 17 | Water use of Kiwifruit vines and apple trees by heat - pulse technique显示文摘 | GREEN R CLOTHIER B E | 1988 | Journal of Experimental Botany1988，39，198： | 1 |
| 18 | The prevalence of nascent entrepreneurs in the United States: evidence from the panel study of entrepreneurial dynandler显示文摘 | Reynolds P D N M Carter W B Gartner P G Greene | 2004 | Small Business Economics2004，23，： | 1 |
| 19 | Use of ozone in the food industry显示文摘 | Zeynep B Guzel-Seydim Annel K Greene A C Seydim | 2004 | Lebensm -Wiss u -Technol2004，37，： | 1 |
| 20 | Dietcomposition and quality in Himalayan musk deer based on facal anasalysis显示文摘 | Green M J B | 1987 | Journal of Wildlife Management1987，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员