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| 1 | Current oncologic applications of radiofrequency ablation therapies显示文摘Radiofrequency ablation (RFA) uses high frequency alternating current to heat a volume of tissue around a needle electrode to induce focal coagulative necrosis with minimal injury to surrounding tissues. RFA can be performed via an open, laparoscopic, or image guided percutaneous approach and be performed under general or local anesthesia. Advances in delivery mechanisms, electrode designs, and higher power generators have increased the maximum volume that can be ablated, while maximizing oncological outcomes. In general, RFA is used to control local tumor growth, prevent recurrence, palliate symptoms, and improve survival in a subset of patients that are not candidates for surgical resection. It's equivalence to surgical resection has yet to be proven in large randomized control trials. Currently, the use of RFA has been well described as a primary or adjuvant treatment modality of limited but unresectable hepatocellular carcinoma, liver metastasis, especially colorectal cancer metastases, primary lung tumors, renal cell carcinoma, boney metastasis and osteoid osteomas. The role of RFA in the primary treatment of early stage breast cancer is still evolving. This review will discuss the general features of RFA and outline its role in commonly encountered solid tumors. | Dhruvil R Shah Sari Green Angelina Elliot John P McGahan Vijay P Khatri | 2013 | World Journal of Gastrointestinal Oncology2013，5，4： | 33 |
| 2 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 3 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 4 | Polysulphide pulping of two Canadian softwood blend显示文摘 | Green R P Prusas Z C | 1975 | Pulp Paper Can1975，76，9： | 2 |
| 5 | Computing dirichlet tessellations in the plane 显示文摘 | Green P J Sibson R | 1978 | Commputer Journal1978，21，2： | 2 |
| 6 | Computing dirichlet tessellations in the plane 显示文摘 | Green P J Sibson R R | 1978 | The Computer Journal1978，21，： | 1 |
| 7 | Mechanisms of Disease: the Myeloprolife Rative Disorders显示文摘 | Campbell P J Green A R | 2006 | N Engl J Med2006，355，： | 1 |
| 8 | Thermal annealing of fission tracks in apatite:A quantitative analysis显示文摘 | Lastett G M Green P F Duddy I R | 1987 | Chemical Geology1987，73，25： | 1 |
| 9 | Male-to-female sex reversal in mice lacking fibroblast growth factor 9显示文摘 | Colvin J S Green R P Schmahl J | 2001 | Cell2001，104，6： | 1 |
| 10 | The soil and water assessment tools: historical development, ap- plications, and future research directions显示文摘 | Gassman P W Reyes M R Green C H | 2007 | Transac- tions of the ASABE2007，50，4： | 1 |
| 11 | Size dependent elemental composition of road-associated particles 显示文摘 | McKenzie E R Wong C M Green P G | 2008 | Science of the Total Enviromnent2008，398，： | 1 |
| 12 | a quantitative analysis显示文摘 | LASLETT G M GREEN P F DUDDY I R et' al Thermal annealing of fission tracks in apatite 2 | 1987 | Chemical Geology1987，65，1： | 1 |
| 13 | Fission track lengths in the apatite annealing zone and the interpretation of mixed ages显示文摘 | Gleadow J W Duddy I R Green P F | 1986 | Earth and Planetary Science Letters1986，78，23： | 1 |
| 14 | Thermal annealing of fission tracks in apatite: A quantitative analysis显示文摘 | Laslett G M Green P F Duddy I R | 1987 | Chem Geol1987，65，1： | 1 |
| 15 | The soil and water assessment tool: historical development, applications, and future research directions 显示文摘 | Gassman P W Reyes M R Green C H | 2007 | American Society of Agriculture and Biology Engineers2007，50，4： | 1 |
| 16 | The importance of advancing technology to America's energy goals显示文摘 | GREENE D L BOUDREAUX P R DEAN D J | 2010 | Energy Policy2010，38，8： | 1 |
| 17 | Transplantation of embryonic dopamine neurons for severe Parkinson's disease显示文摘 | Freed C R Greene P E Breeze R E | 2001 | N Engl J Med2001，344，10： | 1 |
| 18 | C3d enhancement of neutralizing antibodies to measles hemagglutinin显示文摘 | Green T D Newtort B R Rota P A | 2001 | Vaccine2001，20，12： | 1 |
| 19 | Dipeptidyl peptidase IV (DPP IV) inhibitors: a newly emerging drug class for the treatment of type 2 diabetes 显示文摘 | Green B D Flatt P R Bailey C J | 2006 | Diabetes Vasc Dis Res2006，3，3： | 1 |
| 20 | Confined Track Lengths in Apatite:A Diagnostic Tool for Thermal History Analysis显示文摘 | Gleadow A J W Duddy I R Green P F | 1986 | Contributions to Mineralogy and Petrology1986，94，1： | 1 |
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