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| 1 | A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility显示文摘Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particularly in those with hypogonadism,elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic–pituitary–testicular axis by suppressing follicle-stimulating hormone(FSH)and luteinizing hormone(LH)production and impaired spermatogenesis.Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase endogenous testosterone production and improve spermatogenesis in the setting of infertility is an off-label option for treatment.We carried out a systematic review and meta-analysis of the literature of the past 30 years in order to evaluate the benefits of the use of aromatase inhibitors in the medical management of infertile/hypoandrogenic males.Overall,eight original articles were included and critically evaluated.Either steroidal(Testolactone)or nonsteroidal(Anastrozole and Letrozole)aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile.While the evidence is promising,future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications. | Francesco Del Giudice Gian Maria Busetto Ettore De Berardinis Isabella Sperduti Matteo Ferro Martina Maggi Martin S Gross Alessandro Sciarra Michael L Eisenberg | 2020 | Asian Journal of Andrology2020，22，4： | 5 |
| 2 | CT-guided cutting needle biopsy of lung lesions—An effective procedure for adequate material and specific diagnose显示文摘 | Marcos Duarte Guimaraes Marcony Queiroz de Andrade Alexandre Calabria da Fonte Rubens Chojniak Jefferson Luiz Gross | 2010 | European Journal of Radiology2010，，3： | 2 |
| 3 | How small could a pup sound? The physical bases of signaling body size in harbor seals显示文摘 | Andrea RAVIGNANI Stephanie GROSS Maxime GARCIA Ana RUBIO-GARCIA Bart DE BOER | 2017 | Current Zoology2017，63，4： | 2 |
| 4 | Alcohol consumption and domain-specific cognitive function in older adults: longitudinal data from the Johns Hopkins Precursors Study显示文摘 | Gross AL Rebok GW Ford DE | 2011 | J Gerontol B Psychol Sci2011，66，1： | 1 |
| 5 | Diabetic nephropathy:diagnosis,prevention,and treatment显示文摘 | Gross J L de Azevedo MJ Silveiro SP | | 0，，： | 1 |
| 6 | Diabetic nephropathy: diagnosis, prevention, and treatment显示文摘 | Gross JL de Azevedo MJ Silveiro SP | 2005 | Diabetes Care2005，28，1： | 1 |
| 7 | Diabetic nephropathy: diagnosis, prevention, and treatment 显示文摘 | Gross JL de Azevedo MJ Silveiro SP | 2005 | Diabetes Care2005，28，1： | 1 |
| 8 | Diabetic nephropathy: diagnosis, prevention, and treatment 显示文摘 | Gross JL de Azevedo M J Silveiro SP | 2005 | Diabetes Care2005，28，1： | 1 |
| 9 | Improving the efficiency and efficacy of pre-analytical and analytical work-flow of urine cultures with urinary flow cytometry 显示文摘 | Gross S Bruschetta G De Rosa R | 2008 | New Microbiol2008，，： | 1 |
| 10 | Kappa-opioid receptor antagonism improves recovery from myocardial stunning in chronically instrumented dogs显示文摘 | GROSSE HARTLAGE M A THEISEN M M MONTEIRO DE OLIVEIRA N P | 2006 | Anesth Analg2006，103，4： | 1 |
| 11 | Link between heart disease, cholesterol, and Alzheimer's disease : a review 显示文摘 | Sparks DE Martin TA Gross DR | 2000 | Microsc Res Tech2000，50，2： | 1 |
| 12 | Aurilides B and C, cancer cell toxins from a papua new guinea collection of the marine cyanobacterium Lyngbya majuscula 显示文摘 | Han B Gross H Goeger DE | 2006 | J Nat Prod2006，69，： | 1 |
| 13 | Development and validation of a disease extent index for Wegener's granulomatosis显示文摘 | de Groot K Gross W L Herlyn K | 2001 | Clin Nephrol2001，55，： | 1 |
| 14 | The arthroscopic treatment of degenerative joint disease of the knee显示文摘 | Gross DE Brener SL Esformes I | | 0，，12： | 1 |
| 15 | The prognostic value of fimc- tional capacity evaluation in patients with chronic low back pain: part 1 : timely retum to work显示文摘 | Gross DE Batti6 MC Cassidy JD | 2004 | Spine2004，29，8： | 1 |
| 16 | Degradation and solubilization of pectin by β-galactosidases purified from avocadomesocarp显示文摘 | de Veau E J I Gross K C Huber D J | 1993 | Plant Physiol1993，87，： | 1 |
| 17 | Physiopathological aspects of corpus luteum defect in infertile patients with mild/minimal endometriosis显示文摘 | Cuuha-Filho JS Gross JL Bastos de Souza CA | 2003 | J Assist Reprod Genet2003，20，3： | 1 |
| 18 | Diabetic nephropathy: diagnosis, prevention, and treatment显示文摘 | Gross J L de Azevedo M J Silveiro S P | 2005 | Dia- betes Care2005，28，1： | 1 |
| 19 | Diabetic nephropathy: diagnosis, prevention,and treatment 显示文摘 | Gross JL1 de Azevedo MJ Silveiro SP | 2005 | Diabetes care2005，28，1： | 1 |
| 20 | Diabetic nephrop- athy: diagnosis, prevention, and treatment显示文摘 | Gross JL de Azevedo MJ Silveiro SP | 2005 | Diabetes Care2005，28，： | 1 |
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