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| 1 | 【特刊综述】肥胖男性低睾酮的发生机制、发病率及其处理显示文摘随着亚洲现代化和城市化的日益进展,肥胖流行病的未来焦点多在亚洲地区。肥胖男性常会出现低睾酮水平,但他们并不一定有可识别的下丘脑.垂体.睾丸轴(HPT)病理变化。中度肥胖主要降低总睾酮水平,这是由胰岛素抵抗相关的性激素结合球蛋白减少所致。比较严重的肥胖与游离睾酮水平降低有关,这是由下丘脑-垂体-睾丸轴的抑制所致。低睾酮本身可导致肥胖的高风险增加,产生一个恶性循环的代谢综合征。肥胖相关的低睾酮血症是一个功能状态,而非恒定状态。这种状态是可以被逆转的,但这需要持续的减肥。虽然睾酮治疗可以引起中度的脂肪减少,但肥胖本身,在没有雄激素缺乏症状的情况下,不是既定的睾酮治疗的适应症。睾酮治疗可能会导致未经治疗的睡眠呼吸暂停恶化,损害生育能力等。睾酮治疗是否增加饮食或者运动诱导的体重降低需要在充分设计的随机对照临床试验中评估。 | Mark Ng Tang Fui | 2014 | Asian Journal of Andrology2014，16，2： | 28 |
| 2 | 低碳源条件下利用侧流活性污泥水解技术强化生物脱氮除磷显示文摘污水水质特性是决定生物脱氮除磷工艺处理效能的关键性影响因素,尤其是进水中可快速降解有机物(rbCOD)及挥发性脂肪酸(VFA)浓度与N、P浓度比值的高低,直接制约了N、P的去除效率,补加外部碳源往往成为污水处理厂迫不得已的选择,但是外部商业碳源会导致高昂的运行费用及其他运行问题。近十年来,充分挖掘优先利用污水处理厂内碳源技术在国外得到发展和应用。介绍了回流活性污泥(RAS)进行水解补充碳源的技术优势及工艺选择,就采用RAS侧流水解发酵在国内某厂实施技术示范项目进行了介绍,以期为国内在开发活性污泥可持续性利用技术方面提供借鉴。 | 刘智晓 Gert Petersen 张伟 Alexander Grossmann 詹卫东 | 2013 | 给水排水2013，39，1： | 11 |
| 3 | Hematological changes during androgen deprivation therapy显示文摘雄激素剥夺治疗(ADT ) 与不利效果的过多被联系了,与多重繁殖、体的纸巾的雄激素相关性一致。一如此的纸巾是 hemopoietic 系统,并且 ADT 的最可预言的后果之一是贫血症的开发。尽管 ADT 引起的贫血症是很少严重, ADT 经常与增加的危险性被给脆弱的、老人到贫血症由于多重另外的原因。联系 ADT 的贫血症可以贡献疲劳并且减少在如此的人的生活(QoL ) 的质量,尽管这要求进一步的学习。当贫血症是在有前列腺癌症的人的死亡的一个独立风险因素时,联系 ADT 的贫血症的治疗是否改变临床上重要的结果,或治疗是否影响死亡,不被知道。导致 ADT 的贫血症的现象的了解应该在正常红血球的 normochromic 贫血症的温和情况中避免不必要的病情的检查。然而,对更多的严重贫血症的评价和治疗可以被要求。这应该在一个单个基础上被决定。与红血球生成上的 ADT 的描述得好的行动相对照,它另外的 hemopoietic 系上的效果是更少很好阐明。当现出症状之前的潜的研究在成熟为雄激素发现了角色并且区分了 neutrophils,淋巴细胞和血小板的功能时,为有收到 ADT 的前列腺癌症的人的这些调查结果的含意要求进一步的研究。 | Mathis Grossmann Jeffrey D Zajac | 2012 | Asian Journal of Andrology2012，14，2： | 9 |
| 4 | Energy and Water Optimization in Biofuel Plants显示文摘In this paper we address the topic of energy and water optimization in the production of bioethanol from corn and switchgrass. We show that in order for these manufacturing processes to be attractive,there is a need to go beyond traditional heat integration and water recycling techniques. Thus,we propose a strategy based on mathe-matical programming techniques to model and optimize the structure of the processes,and perform heat integration including the use of multi-effect distillation columns and integrated water networks to show that the energy effi-ciency and water consumption in bioethanol plants can be significantly improved. Specifically,under some circum-stances energy can even be produced and the water consumption can be reduced below the values required for the production of gasoline. | Ignacio E. Grossmann Mariano Martin | 2010 | Chinese Journal of Chemical Engineering2010，18，6： | 5 |
| 5 | Diagnosis and treatment of hypogonadism in older men: proceed with caution显示文摘 | Mathis Grossmann | 2010 | Asian Journal of Andrology2010，12，6： | 4 |
| 6 | Live Cell Imaging with R-GEC01 Sheds Light on fig22- and Chitin-Induced Transient [Ca2+]cyt Patterns in Arabidopsis显示文摘细胞内部的 Ca 2+ transients 在触发的联系病原体的分子的模式(PAMP ) 期间是发信号的串联的不可分的部分在植物的免疫。然而,我们导致 PAMP 的 Ca 2+ 信号的空间分发的知识是有限的。房间的调查 -- 并且表明 processesrequires 的 Ca 2+-dependent 的织物特定的性质万用的 Ca 2+ reportersthat 能提取空间信息从细胞并且 subcellular 结构,以及从整个纸巾随着时间的过去从秒的经期到小时。空间的基于荧光的记者盖子 botha 女人和时间的范围,它理想地做他们适合学习在生活房间发信号的 Ca 2+ 。在这研究,我们比较了二个基于荧光的 Ca 2+ 传感器:Förster 回声精力转移(烦恼) 基于的记者黄 cameleon NES-YC3.6 和基于紧张的传感器 R-GECO1。我们证明 R-GECO1 响应几刺激与 ratiometric NES-YC3.6 相比展出一个显著地增加的信号变化。由于它的优异敏感, R-GECO1 能在细胞的规模上报导导致 flg22 、导致几丁质的 Ca 2+ 信号,它允许鉴定定义[Ca 2+] cyt 摆动在表皮并且响应真菌的 elicitor 几丁质的警卫房间。而且,我们发现在根的导致 flg22 、导致几丁质的 Ca 2+ 信号从延伸地区开始。 | Nana F. Keinath Rainer Waadt Rik Brugman Julian I. Schroeder Guido Grossmann Karin Schumacher Melanie Krebs | 2015 | Molecular Plant2015，8，8： | 4 |
| 7 | Balance of adiponectin and leptin modulates breast cancer cell growth显示文摘 | Michael E Grossmann Amitabha Ray Soner Dogan Nancy K Mizuno Margot P Cleary | 2008 | Cell Research2008，18，11： | 3 |
| 8 | In ovo leptin administration affects hepatic lipid metabolism and microRNA expression in newly hatched broiler chickens显示文摘Background: A leptin-like immunoreactive substance has been found in chicken eggs and has been implicated in serving as a maternal signal to program offspring growth and metabolism. In the present study, we investigated the effects of in ovo leptin administration on hatch weight, serum and hepatic concentrations of metabolites and hormones, as well as on the expression of genes involved in hepatic lipid metabolism and the predicted microRNAs (miRNAs) targeting the affected genes. To this end we injected fertile eggs with either 0.5 μg of recombinant murine leptin or vehicle (PBS) before incubation. Results: Prenatally leptin-exposed chicks showed lower hatch weight, but higher liver weight relative to the body weight, compared to the control group. In ovo leptin treatment increased the hepatic content and serum concentration of leptin in newly hatched chickens. The hepatic contents of triglycerides (TG) and total cholesterol (Tch) were decreased, whereas the serum levels of TG, Tch and apolipoprotein B (ApoB) were increased. The hepatic mRNA expression of sterol regulator element binding protein 1 (SREBP-1c), SREBP-2, hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and cholesterol 7α-hydroxylase 1 (CYP7A1) was significantly up-regulated, as was the protein content of both SREBP-1c and SREBP-2 in hepatic nuclear extracts of leptin-treated chickens. Moreover, out of 12 miRNAs targeting SREBP-1c and/or HMGCR, five were significantly up-regulated in liver of leptin-treated chicks, including gga-miR-200b and gga-miR-429, which target both SREBP-1c and HMGCR. Conclusions: These results suggest that leptin in ovo decreases hatch weight, and modifies hepatic leptin secretion and lipid metabolism in newly hatched broiler chickens, possibly via microRNA-mediated gene regulation. | Yan Hu Rui Zhang Yanhong Zhang Jing Li Roland Grossmann Ruqian Zhao | 2012 | Journal of Animal Science and Biotechnology2012，3，2： | 3 |
| 9 | Supply chain optimization in continuous flexible process networks显示文摘 | Jin-Kwang Bok Ignacio E Grossmann Sunwon Park | 2000 | Ind Eng Chem Res2000，39，5： | 2 |
| 10 | New isolation technique to study apoptosis in human intestinal epithelial cells显示文摘 | Grossmann J Maxson J M Whitacre C M | 1998 | Am J Pathol1998，153，1： | 2 |
| 11 | Coherent destruction of tunneling显示文摘 | Grossmann F Dittrich T Jung P | 1991 | Physical Review Letters1991，67，： | 2 |
| 12 | Tunneling in a periodieally driven bistable system显示文摘 | Grossmann F Hanggi P | 1992 | Europhys Letters1992，18，： | 2 |
| 13 | Effects of estrogens during embryonal development on crowing in the domestic fowl显示文摘 | Marx G Jurkevich A Grossmann R | 2004 | Physiol Behav2004，82，4： | 1 |
| 14 | Dynamic modeling and classical control theory for supply chain management显示文摘 | PEREA E GROSSMANN I | 2000 | Computers and Chemical Engineering2000，24，27： | 1 |
| 15 | An LP/NLP based branch and bound algorithm for convex MINLP optimization problems显示文摘 | Quesada I Grossmann I E | 1992 | Comput Chem Engng1992，16，： | 1 |
| 16 | A decomposition approach for the scheduling of a steel plant production显示文摘 | Harjunkoski I Grossmann I E | 2001 | Computers and Chemical Engineering2001，25，： | 1 |
| 17 | Optimal multiperiod operational planning for utility systems显示文摘 | IYER R R GROSSMANN I E | 1997 | Computers Chemical Engineering1997，21，8： | 1 |
| 18 | TheeffectofphospholipaseA2 inhibitors on proliferation and apoptosis of murine intestinalcells显示文摘 | Longo WE Grossmann EM Erickson B | | 0，，： | 1 |
| 19 | The Amino-Acid Sequence of Bovine Glutathione Peroxidase显示文摘 | Wolfgang A. GüNZLER Gerd J. STEFFENS Adelbert GROSSMANN Sung-Man A. KIM Fritz ?TTING Albrecht WENDEL Leopold FLOHé | 2009 | Hoppe-Seyler′s Zeitschrift für physiologische Chemie2009，，1： | 1 |
| 20 | A simultaneous optimization approach for off-line blending and scheduling of oil-refinery operations显示文摘 | Carlos A. Méndez Ignacio E. Grossmann Iiro Harjunkoski Pousga Kaboré | 2005 | Computers and Chemical Engineering2005，，4： | 1 |
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