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| 1 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 2 | Effects of a Saccharomyces cerevisiae yeast on ruminal fermentation and fibre degradation of maize silages in cows显示文摘 | Guedes C M Gon alves D Rodrigues M A M | 2008 | Anim Feed Sci Tech2008，145，1： | 1 |
| 3 | Validation of an immunoperoxidase monolayer assay for total anti-Vac- cinia virus antibody titration 显示文摘 | Gerber P F Matos A C Guedes M I | 2012 | J Vet Diagn Invest2012，24，2： | 1 |
| 4 | SRY gene increases the risk of developing gonadoblastoma and/or nontumoral gonadal lesions in Turner syndrome显示文摘 | Bianco 13 Lipay M Guedes A | 2009 | lnt J Gynecol Pathol2009，28，： | 1 |
| 5 | Steepness and asymmetry of the largest waves in stormy sea states 显示文摘 | Guedes S C Cherneva Z Antao E M | 2004 | Ocean Engineering2004，，31： | 1 |
| 6 | Preprocessing and postprocessing for materials based on the homogenization method with adaptive finite element method显示文摘 | GUEDES J M KIKUCHI N | 1990 | Computer Methods in Applied Mechanics and Engineering1990，83，： | 1 |
| 7 | Preprocessing and postprocessing for materials based on the homogenization method with adaptive finite element methods 显示文摘 | Guedes J M Kikuchi N | 1990 | Computer Methods in Applied Mechanics and Engineering1990，83，2： | 1 |
| 8 | Simulation modelling of repairable multi-component deteriorating systems for on condition' maintenance optimization 显示文摘 | Barata J Soares C Guedes Marseguerra M Zio E | 2002 | Reliability Engineering and System Safety2002，76，3： | 1 |
| 9 | Generalized topology design of structures with a buckling load criterion显示文摘 | Neves M M Rodrigues H Guedes J M | 1995 | Struct Optim1995，10，： | 1 |
| 10 | Photochemical processes and the environmental impact of petroleum spills 显示文摘 | Nicodem D E Fernandes M C Z Guedes C L B | 1997 | Biogeochemistry1997，39，： | 1 |
| 11 | Effects of metformin on the glycemic control,lipid profile,and arterial blood pressure of type 2 diabetic patients with metabolic syndrome already on insulin显示文摘 | Mourao Junior C A Sa J R Guedes O M | 2006 | Braz J Med Biol Res2006，39，4： | 1 |
| 12 | Nucleation and crystal growth in commercial LAS compositions显示文摘 | Guedes M Ferro A C Ferreira J M F | 2001 | Journal of the E(ur)opean Ceramic Society2001，，21： | 1 |
| 13 | The association of carbonate alteration of banded iron formation with the Carajas high-grade hematite deposits 显示文摘 | Guedes S C Rosiere C A Barley M E | 2003 | Appl Earth Sci2003，12，： | 1 |
| 14 | Study of synthetic ferrimagnet-synthetic antiferromagnet structures for magnetic sensor application显示文摘 | GUEDES A MENDES M J FREITAS P P | 2006 | Journal of Applied Physics2006，99，8： | 1 |
| 15 | Serologic follow-up of a repopulated swine herd after an outbreak of proliferative hemorrhagic enteropathy显示文摘 | Guedes R M C Gebhart C J Armbruster G A | 2002 | Can J Vet Res2002，66，4： | 1 |
| 16 | Preprocessing and postprocessing for materials based on the homogenization method with adaptive finite element methods显示文摘 | Guedes J M Kikuchi N | 1990 | Computer Methods in Applied Mechanics and Engineering1990，83，： | 1 |
| 17 | Adances and perspectives in using microalgae to produce biodiesel显示文摘 | AMANO M HELENA GUEDES CATAEINA MALCATA XAVIER F | 2011 | Applied Energy2011，88，： | 1 |
| 18 | l)oppler ul trasound: a powerful tool for vascular access surveiI lance显示文摘 | Guedes Marques M Ibeas J Botelho C | 2015 | Semin Dial2015，28，2： | 1 |
| 19 | Verresehi IT SRYgene increases the risk of developing gonadoblastoma and/or non-tumoral gonadal lesions in Turner syndrome 显示文摘 | Bianco B Lipay M Guedes A | 2009 | Int J Gyneeol Pathol2009，28，： | 1 |
| 20 | Nucleation and Crystal Growth in Commercial LAS Composition显示文摘 | Guedes M Ferro A C Ferreira J M F | 2001 | Journal of the European Ceramic Society2001，21，： | 1 |
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