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	题名	作者	年代	出处	被引量
1	Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy.	Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf	2012	World Journal of Gastroenterology2012，18，6：	16
2	The ’Terra Preta’ phenomenon: a model for sustainable agriculture in the humid tropics显示文摘	Bruno Glaser Ludwig Haumaier Georg Guggenberger Wolfgang Zech	2001	Naturwissenschaften2001，，1：	2
3	The role of DOM sorption to mineral surfaces in the preservation of organic matter in soils显示文摘	Klaus Kaiser Georg Guggenberger	2000	Organic Geochemistry2000，，7：	2
4	Soil organic matter composition under primary forest,pasture,and secondary forest succession,Region Huetar Norte,Costa Rica显示文摘	GUGGENBERGER G ZECH W	1999	Forest Ecology and Management1999，124，：	1
5	Silo- ranes in dental composites 显示文摘	Wolfgang Weinmann Christoph Thalacker Rainer Guggenberger	2005	Dental Materials2005，21，：	1
6	Lignin and carbohydrate alteration in particle-size separates of an oxisol under tropical pastures following native savanna 显示文摘	GUGGENBERGER G ZECH W and THOMAS R J	1995	Soil Biology and Biochemistry1995，27，12：	1
7	Bacterial and fungal cell-wall residues in conventional and notillage agroecosystems 显示文摘	GUGGENBERGER G FREY SD SIX J	1999	Soil Science Society of American Journal1999，63，：	1
8	Microbial contributions to the aggregation of a cultivated grassland soil amended with starch显示文摘	Guggenberger G Elliott E T Frey S D	1999	Soil Biology&Biochemistry1999，31，3：	1
9	Black carbon in soils:The use of benzenecarboxylic acids as specificmarkers显示文摘	Glaser B Haumaie L Guggenberger G	1998	Organic Geochemistry1998，29，4：	1
10	Bacterial and fungal cell-wall residues in conventional and notillage agroecosystems显示文摘	GUGGENBERGER G FREY S D SIX J	1999	Soil Science Society of American Journal1999，63，：	1
11	Dissolved organic cabon control in acid forest soils of the Fichtelgebirge as revealed by distribution patterns and structural compositon analyses显示文摘	Guggenberger G Zech W	1993	Geoderma1993，59，：	1
12	Diagnostic performance of dual-energy CT for the detection of traumatic bone marrow lesions in the ankle:comparison with MR imaging显示文摘	Guggenberger R Gnannt R Hodler J	2012	Radiology2012，264，1：	1
13	Exploring beyond methacrylates显示文摘	Guggenberger R Weinmann W	2000	Am J Dent2000，13，：	1
14	Land-use and fer- tilization effects on P forms in two European soils:Resin extraction and 31p-NMR analysis显示文摘	Guggenberger G Christensen B T Rubaek G	1996	European Journal of Soil Science1996，47，：	1
15	Composition and dynamics of dissolved carbohydrates and lignin-degradation products in two coniferous forests, NE Bavaria,Germany显示文摘	Guggenberger G Zech W	1994	Soil Biology & Biochemistry1994，26，：	1
16	Acidification effects on dissolved organic matter mobility in spruce forest ecosystems显示文摘	Guggenberger G	1994	Environmental International1994，20，：	1
17	Black carbon in soils:the use of benzene carboxylic acids as specific markers显示文摘	Glaser B Haumaier L Guggenberger G	1998	Organic Geochemistry1998，29，4：	1
18	The Terra Preta' phenomenon: A model for sustainable agricul- ture in the humid tropics 显示文摘	GLASER B HAUMAIER L GUGGENBERGER G	2001	Naturwissenschaften2001，88，1：	1
19	SOM fractionation methods: Relevance to functional pools and to stabilization mechanisms显示文摘	von Ltitzow KOgel-Knabner M Ekschmitt I Flessa K Guggenberger H Matzner G Marschner E	2007	Soil Biology and Bioche- mistry2007，39，9：	1
20	Black carbon in soils: the use of benzenecarboxylic acids as specific markers 显示文摘	Glaser B Haumaier L Guggenberger G	1998	OrgGeoChem1998，29，4：	1

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