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| 1 | Leptin treatment ameliorates acute lung injury in rats with cerulein-induced acute pancreatitis显示文摘AIM:To determine the effect of exogenous leptin on acute lung injury (ALI) in cerulein-induced acute pancreatitis (AP). METHODS:Forty-eight rats were randomly divided into 3 groups. AP was induced by intraperitoneal (i.p.) injection of cerulein (50 μg/kg) four times,at 1 h intervals. The rats received a single i.p. injection of 10 μg/kg leptin (leptin group) or 2 mL saline (AP group) after cerulein injections. In the sham group,animals were given a single i.p. injection of 2 mL saline. Experimental samples were collected for biochemical and histological evaluations at 24 h and 48 h after the induction of AP or saline administration. Blood samples were obtained for the determination of amylase,lipase,tumor necrosis factor (TNF)-a,interleukin (IL)-1β,macrophage inflammatory peptide (MIP)-2 and soluble intercellular adhesion molecule (sICAM)-1 levels,while pancreatic and lung tissues were removed for myeloperoxidase (MPO) activity,nitric oxide (NOx) level,CD40 expression and histological evaluation. RESULTS:Cerulein injection caused severe AP,confirmed by an increase in serum amylase and lipase levels,histopathological findings of severe AP,and pancreatic MPO activity,compared to the values obtained in the sham group. In the leptin group,serum levels of MIP-2,sICMA-1,TNF-a,and IL-1b,pancreatic MPO activity,CD40 expression in pancreas and lung tissues,and NOx level in the lung tissue were lower compared to those in the AP group. Histologically,pancreatic and lungdamage was less severe following leptin administration. CONCLUSION:Exogenous leptin attenuates inflammatory changes,and reduces pro-inflammatory cytokines,nitric oxide levels,and CD40 expression in ceruleininduced AP and may be protective in AP associated ALI. | Fatma Ayca Gultekin Mustafa Kerem Ertan Tatlicioglu Aysel Aricioglu Cigdem Unsal Neslihan Bukan | 2007 | World Journal of Gastroenterology2007，13，21： | 23 |
| 2 | Current role of modern radiotherapy techniques in the management of breast cancer显示文摘Breast cancer is the most common type of malignancy in females. Advances in systemic therapies and radiotherapy(RT) provided long survival rates in breast cancer patients. RT has a major role in the management of breast cancer. During the past 15 years several developments took place in the field of imaging and irradiation techniques, intensity modulated RT, hypofractionation and partial-breast irradiation. Currently, improvements in the RT technology allow us a subsequent decrease in the treatment-related complications such as fibrosis and long-term cardiac toxicity while improving the loco-regional control rates and cosmetic results. Thus, it is crucial that modern radiotherapy techniques should be carried out with maximum care and efficiency. Several randomized trials provided evidence for the feasibility of modern radiotherapy techniques in the management of breast cancer. However, the role of modern radiotherapy techniques in the management of breast cancer will continue to be defined by the mature results of randomized trials. Current review will provide an up-to-date evidence based data on the role of modern radiotherapy techniques in the management of breast cancer. | Gokhan Ozyigit Melis Gultekin | 2014 | World Journal of Clinical Oncology2014，5，3： | 6 |
| 3 | Contractual relationships in family firms: An agency theory interpretation from a managerial perspective显示文摘 | Fatih Semercioz Gultekin Altuntas Mustafa Sundu | 2010 | China-USA Business Review2010，9，1： | 2 |
| 4 | Factors affecting results of patients with humeral proximal end fractures undergoing primary hemiarthroplasty:a retrospective study in 42 patients显示文摘 | Esen E Dogramaci Y Gultekin S | 2009 | Injury2009，40，12： | 1 |
| 5 | The effect of environmental pollution on the heavy metal content of raw milk 显示文摘 | Simsek O Gultekin R Oksuz | 2000 | Nahrung-Food2000，5，44： | 1 |
| 6 | Diaphragmatic paralysis after cardiac surgery in children: incidence, prognosis and surgical management显示文摘 | Akay T H Ozkan S Gultekin B | 2006 | Pediatr Surg Int2006，22，4： | 1 |
| 7 | Pure cycles in flexible robotic cells显示文摘 | Gultekin H Karasan O E Akturk M S | 2009 | Computers & Operations Research2009，36，2： | 1 |
| 8 | Variations and trends in Turkish seasonal heating and cooling degree-day 显示文摘 | Kadiolu M Sen Z Gultekin L | 2001 | Climatic Change2001，49，12： | 1 |
| 9 | Regional chemotherapy for unresectable primary liver cancer:results of a phase Ⅱ clinical trial and assessment of DCE-MRI as a biomarker of survival显示文摘 | Jarnagin WR Schwartz LH Gultekin DH | 2009 | Ann Oncol2009，20，9： | 1 |
| 10 | Technique and consid- erations when using external fixation as a standard treatment of femoral fractures in children 显示文摘 | Schranz PJ Gultekin C Cohon CL | 2004 | Injury2004，5，12： | 1 |
| 11 | Degradation of aryl-azo-naphtholdyes by ultrasound, ozone and their combination:Effect of a-substituents 显示文摘 | Gultekin I Ince N H | 2006 | Ultrason Sonochem2006，13，3： | 1 |
| 12 | Ganglioneuromamimicking ovarian tumor:a report of a case and review of theganglioneuromas显示文摘 | Gultekin M Dursun P Salman C | 2005 | Arch Gynecol Obstet2005，271，1： | 1 |
| 13 | Protective role of melatonin and a combination of vitamin C and vitamin E on lung toxicity induced by chlorpyrifos-ethyl in rats 显示文摘 | Karaoz E Gultekin F Akdogan M | 2002 | Exp Toxicol Pathol2002，54，2： | 1 |
| 14 | Sedation with propofol plus midazolam versus propofol alone for interventional endoscopic procedures:a prospective,randomized study显示文摘 | H SEIFERT TH SCHMITT T GULTEKIN | 2000 | 14:1207-12122000，14，： | 1 |
| 15 | Metastatic lymph node number in epithelial ovarian carcinoma: does it have any clinical significance? 显示文摘 | AYHAN A GULTEKIN M DURSUNP | 2008 | Gynecol Oncol2008，108，2： | 1 |
| 16 | Does hearing loss after spinal anesthesia differ between young and elderly patients?显示文摘 | Gultekin s Ozean S | 2002 | Anesth Analg2002，94，5： | 1 |
| 17 | Effectsof organic and inorganic forms of manganese, zinc, copper, and chromium on bioavailability of these min- erals and calcium in late-phase laying hens 显示文摘 | YENICE E MIZRAK C GULTEKIN M | 2015 | Bio- logical Trace Element Research2015，167，2： | 1 |
| 18 | Synthetic endocrine disruptors in the environment and water remediation by advanced oxidation processes 显示文摘 | Gultekin I Ince NH | 2007 | Journal of Environmental Management2007，85，4： | 1 |
| 19 | Variations and trends in turkish seasonal heating and cooling degree-days 显示文摘 | Mikdat K Zekai S Gultekin L | 2001 | Climatic Change2001，49，12： | 1 |
| 20 | Sedation with propofol plus midazolam versus propofol alone for interventional endoscopic procedures:a prospective,randomized study显示文摘 | Seifert H Schmitt TH Gultekin T | 1999 | J Gastroentero1999，37，7： | 1 |
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