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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Transjugular intrahepatic porto 全身的分流在老: 为门高血压的复杂并发症的减轻显示文摘 AIM:To present a dedicated series of transjugular intrahepatic porto-systemic shunts(TIPS) in the elderly since data is sparse on this population group.METHODS:A retrospective review was performed of patients at least 65 years of age who underwent TIPS at our institutions between 1997 and 2010.Twentyfive patients were referred for TIPS.We deemed that 2 patients were not considered appropriate candidates due to their markedly advanced liver disease.Of the 23 patients suitable for TIPS,the indications for TIPS placement was portal hypertension complicated by refractory ascites alone(n = 9),hepatic hydrothorax alone(n = 2),refractory ascites and hydrothorax(n = 1),gastrointestinal bleeding alone(n = 8),gastrointestinal bleeding and ascites(n = 3).RESULTS:Of these 23 attempted TIPS procedure patients,21 patients had technically successful TIPS procedures.A total of 29 out of 32 TIPS procedures including revisions were successful in 21 patients with a mean age of 72.1 years(range 65-82 years).Three of the procedures were unsuccessful attempts at TIPS and 8 procedures were successful revisions of our existing TIPS.Sixteen of 21 patients who underwent successful TIPS(excluding 5 patients lost to follow-up) were followed for a mean of 14.7 mo.Ascites and/or hydrothorax was controlled following technically successful procedures in 12 of 13 patients.Bleeding was controlled following technically successful procedures in 10 out of 11 patients.CONCLUSION:We have demonstrated that TIPS is an effective procedure to control refractory complications of portal hypertension in elderly patients. | Mubin I Syed Hetal Karsan Hector Ferral Azim Shaikh Uzma Waheed Talal Akhter Alan Gabbard Kamal Morar Robert Tyrrell | 2012 | World Journal of Hepatology2012，4，2： | 4 |
| 3 | GERD: diagnosing and treating the bum 显示文摘 | Alzubaidi M Gabbard S | 2015 | Cleve Clin J Med2015，82，10： | 1 |
| 4 | The concept of boundaries in clinical practice: theoretical and risk-management dimensions 显示文摘 | Gutheil TG Gabbard GO | 1993 | Am J Psychiatry1993，150，2： | 1 |
| 5 | The role of compulsiveness in the normal physician 显示文摘 | Gabbard GO | 1985 | Am J Med1985，254，： | 1 |
| 6 | User-centred design and evaluation of virtual environments显示文摘 | Hix D Swan J E | 1999 | IEEE Computer Graphics and Applications1999，19，6： | 1 |
| 7 | The impact of alcohol consumption and cholecystectomy on small intestinal bacterial overgrowth显示文摘 | Gabbard SL Lacy BE Levine GM | 2014 | Dig Dis Sci2014，59，3： | 1 |
| 8 | Memory T cells generated by prior exposure to influenza cross react with the novel H7N9 influenza virus and confer protective heterosubtypie immunity显示文摘 | MeMaster SR Gabbard JD Koutsonanos DG | 2015 | PLoS One2015，10，01： | 1 |
| 9 | Novel H7N9 in- fluenza virus shows low infectious dose, high growth rate, and efficient contact transmission in the guinea pig model 显示文摘 | Gabbard J D Dlugolenski D Van Riel D | 2014 | J Vi- rol2014，88，3： | 1 |
| 10 | The interdisciplinary influence of li- brary and information seienee 1996-2004: a journal-to-journal citation analysis 显示文摘 | ODELL J GABBARD R | 2008 | College & Research Libraries2008，，6： | 1 |
| 11 | Interlimb coordina- tion:An important facet of gross-motor skill ability显示文摘 | TATIANA B GABBARD C CACOLA P | 2009 | Early Childhood Res Practice2009，11，2： | 1 |
| 12 | NGAL:an emerging tool for predicting severity of AKI is easily detected by a clinical assay显示文摘 | Gabbard W Milbrandt EB Kellum JA | 2010 | Critical Care2010，14，4： | 1 |
| 13 | Gender differences in brazilian children's fundamental movement skill performanee显示文摘 | BARBARA COIRO SPESSATO CARL GABBARD NADIA VALENTINI | | Early Child Development and Care0，，： | 1 |
| 14 | The role of compulsiveness in the normal physician 显示文摘 | Gabbard GO | 2005 | Journal of American Medical Association2005，254，： | 1 |
| 15 | Wide ecological amplitude of a diversity-reducing invasive grass显示文摘 | Gabbard B L Fowler N L | 2007 | Biological Invasions2007，9，2： | 1 |
| 16 | Single-dose vaccination of a recombinant parainfluenza virus 5 expressing NP from HSN1 virus provides broad immunity against influenza A viruses显示文摘 | Li Z Gabbard J D Mooney A | 2013 | J Virol2013，87，10： | 1 |
| 17 | GERD : Diagnosing and treating the burn 显示文摘 | Alzubaidi M Gabbard S | 2015 | Cleve Clin J Med2015，82，10： | 1 |
| 18 | Chronic intestinal pseudoobstruction显示文摘 | Gabbard SL1 Lacy BE | 2013 | Nutr Clin Pract2013，28，： | 1 |
| 19 | A Neuroscience Perspective On Transference显示文摘 | Gabbard G O | 2006 | International Congress Series2006，1286，： | 1 |
| 20 | Is there an advanced aging effect on the ability to mentally represent action显示文摘 | Carl Gabbard Priscila Cacola Alberto Cordova | 2011 | Arch Gerontol Geriat2011，53，： | 1 |
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