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| 1 | Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities显示文摘Acute myocardial infarction(AMI) is the leading cause of death worldwide. Its associated mortality, morbidity and complications have significantly decreased with the development of interventional cardiology and percutaneous coronary angioplasty(PCA) treatment, which quick-ly and effectively restore the blood flow to the area previously subjected to ischemia. Paradoxi-cally, the restoration of blood flow to the ischemic zone leads to a massive production of reactive oxygen species(ROS) which generate rapid and severe damage to biomolecules, generating a phenomenon called myocardial reperfusion injury(MRI). In the clinical setting, MRI is associated with multiple complications such as lethal reperfusion, no-reflow, myocardial stunning, and reperfusion arrhythmias. Despite significant advances in the understanding of the mechanisms accounting for the myocardial ischemia reperfusion injury, it remains an unsolved problem. Although promising results have been obtained in experimental studies(mainly in animal models), these benefits have not been translated into clinical settings. Thus, clinical trials have failed to find benefits from any therapy to prevent MRI. There is major evidence with respect to the contribution of oxidative stress to MRI in cardiovascular diseases. The lack- of consistency between basic studies and clinical trials is not solely based on the diversity inherent in epidemiology but is also a result of the methodological weak-nesses of some studies. It is quite possible that pharmacological issues, such as doses, active ingredients, bioavailability, routes of administration, co-therapies, startup time of the drug intervention,and its continuity may also have some responsibility for the lack- of consistency between different studies. Furthermore, the administration of high ascorbate doses prior to reperfusion appears to be a safe and rational therapy against the development of oxidative damage associated with myocardial reperfusion. In addition, the association with N-acetylcysteine(a glutathione donor) and deferoxamine(an iron chelator) could improve the antioxidant cardioprotection by ascorbate, mak-ing it even more effective in preventing myocardial reperfusion damage associated with PCA following AMI. | Jaime González-Montero Roberto Brito Abraham IJ Gajardo Ramón Rodrigo | 2018 | World Journal of Cardiology2018，10，9： | 56 |
| 2 | Neuroprotective effects of erythropoietin on neurodegenerative and ischemic brain diseases: the role of erythropoietin receptor显示文摘Erythropoietin(Epo) is a fundamental hormone in the regulation of hematopoiesis, and other secondary roles mediated by the binding of the hormone to its specific receptor(Epo R), which leads to an activation of key signaling pathways that induce an increase in cell differentiation, apoptosis control and neuroprotection. It has been suggested that their function depends on final conformation of glycosylations, related with affinity to the receptor and its half-life. The presence of Epo R has been reported in different tissues including central nervous system, where it has been demonstrated to exert a neuroprotective function against oxidative stress conditions, such as ischemic injury and neurodegenerative diseases. There is also evidence of an increase in Epo R expression in brain cell lysates of Alzheimer's patients with respect to healthy patients. These results are related with extensive in vitro experimental data of neuroprotection obtained from cell lines, primary cell cultures and hippocampal slices. Additionally, this data is correlated with in vivo experiments(water maze test) in mouse models of Alzheimer's disease where Epo treatment improved cognitive function. These studies support the idea that receptor activation induces a neuroprotective effect in neurodegenerative disorders including dementias, and especially Alzheimer's disease. Taken together, available evidence suggests that Epo appears to be a central element for Epo R activation and neuroprotective properties in the central nervous system. In this review, we will describe the mechanisms associated with neuroprotection and its relation with the activation of Epo R in order with identify new targets to develop pharmacological strategies. | Carolina Castillo Hernández Carlos Felipe Burgos Angela Hidalgo Gajardo Tiare Silva-Grecchi Javiera Gavilan Jorge Roberto Toledo Jorge Fuentealba | 2017 | Neural Regeneration Research2017，12，9： | 5 |
| 3 | Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics显示文摘 | Rodriguez JP Garat S Gajardo H | 1999 | J Cell Biochem1999，75，3： | 1 |
| 4 | The brine shrimp Artemia: adapted to critical life condition 显示文摘 | Gajardo G M Beardmore J A | 2012 | Fronters in Physiology2012，3，： | 1 |
| 5 | Activation of the interferon- inducible protein kinase PKR by hepatocellular carcinoma derived- hepatitis C virus core protein显示文摘 | Delhem N Sabile A Gajardo R | 2001 | Oncogene2001，20，： | 1 |
| 6 | The effect of storage at different temperatures on the stability of Hepatitis C virus RNA in plasma samples显示文摘 | Jose M Curtu S Gajardo R | 2003 | Biologicals2003，31，1： | 1 |
| 7 | Viral safety characteris-tics of Flebogamma DIF, a new pasteurized, solvent-detergenttreated and Planova 20 nm nanofiltered intravenous immunoglobu-lin 显示文摘 | Caballero S Nieto S Gajardo R | 2010 | Biologicals2010，38，4： | 1 |
| 8 | Ecosystem value in the Western Patagonia protected areas显示文摘 | MARTINEZ-HARMS M J GAJARDO R | 2008 | Journal for Nature Conservation2008，16，2： | 1 |
| 9 | Genotyping of rotaviruses isolated from sewage显示文摘 | GAJARDO R BOUCHRIYI N PINTO R M | 1995 | Applied and Environmental Microbiology1995，61，9： | 1 |
| 10 | Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Chilean population显示文摘 | Gajardo M Silva N Gomez L | 2005 | J Periodontol2005，76，2： | 1 |
| 11 | Submerged macrophyte con- trol with herbivorous fish in irrigation channels of semiarid Argentina 显示文摘 | Armellina A A D Bezic C R Gajardo O A | 1999 | Hydroblologia1999，415，： | 1 |
| 12 | Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics显示文摘 | Rodriguez JP Garat S Gajardo H | 1999 | J Cell Biochem1999，75，3： | 1 |
| 13 | Astrovirus survival in drinking water显示文摘 | Abad FX Pint6 R Villena C Gajardo R Bosch A | 1997 | Appl Environ Microbiol1997，63，8： | 1 |
| 14 | Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the antiviral effect of interferon in a PKR-independent manner 显示文摘 | Podevin P Sabile A Gajardo R | 2001 | Hepatology2001，33，6： | 1 |
| 15 | Effects of treatment with GH alone or in combination with LHRH analog on bone mineral density in pubertal GH -deficient patients显示文摘 | Mericq V Gajardo H Eggers M | 2002 | J Clin Endoerinol Metab2002，87，1： | 1 |
| 16 | On time-symmetry in cellular automata显示文摘 | Gajardo A Kari J Moreira A | 2012 | Journal of Computer and System Sciences2012，78，4： | 1 |
| 17 | Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats显示文摘 | Roa H Gajardo C Troncoso E | 2009 | FEBS Lett2009，583，19： | 1 |
| 18 | Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics 显示文摘 | Rodriguez JP Garat S Gajardo H | 1999 | J Cell Biochem1999，75，3： | 1 |
| 19 | Effects of treat-ment with GH alone or in combination with LHRH analog on bone mineral density in pubertal GH-deficient patients显示文摘 | Mericq V Gajardo H Eggers M | 2002 | J Clin Endocrinol Metab2002，87，1： | 1 |
| 20 | 显示文摘 | Delhem N Sabile A Gajardo R | 2001 | Oncogene2001，20，： | 1 |
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