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| 1 | Sex differences in cognitive impairment in Alzheimer's disease显示文摘Sex differences in neurocognitive abilities have been extensively explored both in the healthy population andin many disorders. Until recently, however, little work has examined such differences in people with Alzheimer's disease(AD). This is despite clear evidence that AD is more prevalent in women, and converging lines of evidence from brain imaging, post-mortem analyses, hormone therapy and genetics suggesting that AD affects men and women differently. We provide an overview of evidence attesting to the poorer cognitive profiles in women than in men at the same stage of AD. Indeed, men significantly outperform women in several cognitive domains, including: Language and semantic abilities, visuospatial abilities and episodic memory. These differences do not appear to be attributable to any differences in age, education, or dementia severity. Reasons posited for this female disadvantage include a reduction of estrogen in postmenopausal women, greater cognitive reserve in men, and the influence of the apolipoprotein E ε4 allele. Assessment of cognitive abilities contributes to the diagnosis of the condition and thus, it is crucial to identify the role of sex differences if potentially more accurate diagnoses and treatments are to emerge. | Keith R Laws Karen Irvine Tim M Gale | 2016 | World Journal of Psychiatry2016，6，1： | 18 |
| 2 | Rht8、Rht10和Rht12矮秆基因对产量构成因子的影响显示文摘利用携带不同矮秆基因的近等基因系,通过两年、两地的试验研究证明,Rht8半矮秆基因虽然其总小穗数显著低于其他系,但其籽粒产量、小花结实率较Rht10和Rht12显著高。Rht10的降秆作用最强,千粒重显著高于Rht8,但其分蘖成穗率、结实率及小区籽粒产量显著低于其他,表现对环境条件特敏感。Rht12矮秆基因的降秆程度显著高于Rht8,但由于生物产量太低、成熟太晚,造成籽粒产量显著降低,在小麦育种中单独利用价值较低。 | 李杏普 兰素缺 张京慧 冯延茹 刘书娥 张业伦 Gale M D Worland T J | 2009 | 华北农学报2009，24，B12： | 8 |
| 3 | Rht8、Rht10、Rht12矮杆基因对小麦营养生长和生殖生长发育的影响显示文摘两年、两地的试验结果证明,Rht8半矮秆基因对地上部生物产量较Rht10和Rht12有显著的正向作用,并且生长发育较早,较接近目前推广种的生育时期,对不良环境有较强的适应性,利于产量性状的形成。Rht10的降秆作用最强,但由于节间缩短太多,造成地上部生物产量明显降低,使籽粒形成时提供营养的'源'太少,不利于高产。Rht12矮秆基因的降秆程度显著高于Rht8,但生物产量亦太低、成熟太晚和对环境条件的不适应,影响籽粒产量的提高,在以降秆为主要目标的育种中利用价值较大。 | 李杏普 兰素缺 张业伦 张京惠 冯延茹 刘书娥 Gale M D Worland T J | 2009 | 华北农学报2009，24，B08： | 7 |
| 4 | Risk stratification for ST segment elevation myocardial infarction in the era of primary percutaneous coronary intervention显示文摘Acute coronary syndromes presenting with ST elevation are usually treated with emergency reperfusion/revascularisation therapy. In contrast current evidence and national guidelines recommend risk stratification for non ST segment elevation myocardial infarction(NSTEMI) with the decision on revascularisation dependent on perceived clinical risk. Risk stratification for STEMI has no recommendation. Statistical risk scoring techniques in NSTEMI have been demonstrated to improve outcomes however their uptake has been poor perhaps due to questions over their discrimination and concern for application to individuals who may not have been adequately represented in clinical trials. STEMI is perceived to carry sufficient risk to warrant emergency coronary intervention [by primary percutaneous coronary intervention(PPCI)] even if this results in a delay to reperfusion with immediate thrombolysis. Immediate thrombolysis may be as effective in patients presenting early, or at low risk, but physicians are poor at assessing clinical and procedural risks and currently are not required to consider this. Inadequate data on risk stratification in STEMI inhibits the option of immediate fibrinolysis, which may be cost-effective. Currently the mode of reperfusion for STEMI defaults to emergency angiography and percutaneous coronary intervention ignoring alternative strategies. This review article examines the current risk scores and evidence base for risk stratification for STEMI patients. The requirements for an ideal STEMI risk score are discussed. | Richard A Brogan Christopher J Malkin Philip D Batin Alexander D Simms James M McLenachan Christopher P Gale | 2014 | World Journal of Cardiology2014，6，8： | 6 |
| 5 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 6 | Prevalence of extended spectrum β- lactamase(ESBLs) -Producing clincal isolates in the Asia- Pacific region and south Africa:regional results from SENTRY Antimicrobial surveillance program( 1998 -99 ) 显示文摘 | Bell M Tumidge JD Gales AC | 1998 | Diag Microbiol Infct Dis1998，，： | 1 |
| 7 | Plant comparative genetics after 10 years显示文摘 | Gale M D Devos K | 1998 | Science1998，282，： | 1 |
| 8 | Vitamin A-deficient quail embryos have half a hindbrain and other neural defects显示文摘 | Maden M Gale E Kostetskii I | 1996 | Curr Biol1996，6，4： | 1 |
| 9 | Structure-activity relationship for antioxidant activities of a series of flavonoids in a liposomal system显示文摘 | Arti Arora Muraleedharan G Nair Gale M Strasburg | 1998 | Free Radical Biology & Medicine1998，24，9： | 1 |
| 10 | The use of random amplified polymorphic DNA markers in wheat显示文摘 | Devos K M Gale M D | 1992 | Theoretical and Applied Genetics1992，84，： | 1 |
| 11 | Haploinsufficiency of delta- like 4 ligand results in embryonic lethality due to ma:or defects in arterial and vascular development显示文摘 | Gale N W Dominguez M G Noguera I Pan L Hughes V Va]enzuela D M | 2004 | Proc Natl Acad Sci USA2004，101，15： | 1 |
| 12 | Simple sequence repeat(SSR)marker survey of the cassava(Manihot esculenta Crantz)genome:toward a SSR-based molecular genetic map of cassava显示文摘 | Mba R E C Stephenson P Edwards K Mezer S Nkumbira J Gulberg U Apel K Gale M Tohme J Fregene M A | | 0，，： | 1 |
| 13 | Application of MRI to monitor the process of ripening and decay in citrus treated with chitosan solutions显示文摘 | Galed G Fernández-Valle M E Martinez A | 2004 | Magnetic Resonance Imaging2004，22，1： | 1 |
| 14 | Mean and variance adaptation within the MLLR framework 显示文摘 | Gales M J F Woodland P C | 1996 | Computer Speech and Language1996，10，4： | 1 |
| 15 | Binding characteristics of an androgen receptor in the ovaries of coho salmon,Oncorhynchus kisutch显示文摘 | Fitzpatrick M S Gale M L Schreck C B | 1994 | Gen Comp Endocrinol1994，95，： | 1 |
| 16 | Colorimetric assay for methanesulfinic acid in biological samples 显示文摘 | Babbs F C Gale J M | 1987 | Analytical Biochemistry1987，163，1： | 1 |
| 17 | Fabrication of microoptical components by laser beam writing in photoresist显示文摘 | Michael T Gale Graham K Lang Jeffrey M Raynor | 1991 | SPIE1991，1506，： | 1 |
| 18 | Survival of the fittest? Natural selection in islet transplantation显示文摘 | SMITH R M GALE E A M | 2005 | Transplantation2005，79，10： | 1 |
| 19 | Plant comparative genetics after 10 years 显示文摘 | Gale M D Devos K M | 1998 | Science1998，282，： | 1 |
| 20 | Natural fractures in the Barnett shale and their importance for hydraulic fracture treatments显示文摘 | Gale J F W Reed R M Holder J | 2007 | AAPG Bulletin2007，91，4： | 1 |
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