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| 1 | Peritoneal carcinosis of ovarian origin显示文摘Epithelial ovarian cancer (EOC) is the second most common genital malignancy in women and is the most lethal gynecological malignancy,with an estimated five-year survival rate of 39%.Despite efforts to develop an effective ovarian cancer screening method,60% of patients still present with advanced disease.Comprehensive management using surgical cytoreduction to decrease the tumor load to aminimum,and intraperitoneal chemotherapy to eliminate microscopic disease on peritoneal surface,has the potential to greatly improve quality of life and to have an impact on survival in ovarian cancer patients.Despite achieving clinical remission after completion of initial treatment,most patients (60%) with advanced EOC will ultimately develop recurrent disease or show drug resistance;the eventual rate of curability is less than 30%.Given the poor outcome of women with advanced EOC,it is imperative to continue to explore novel therapies. | Anna Fagotti Valerio Gallotta Federico Romano Francesco Fanfani Cristiano Rossitto Angelica Naldini Massimo Vigliotta Giovanni Scambia | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 5 |
| 2 | Prevalence of functional dyspepsia and its subgroups in patients with eating disorders显示文摘AIM:To study the prevalence of functional dyspepsia(FD)(Rome Ⅲ criteria) across eating disorders(ED),obese patients,constitutional thinner and healthy volunteers.METHODS:Twenty patients affected by anorexia nervosa,6 affected by bulimia nervosa,10 affected by ED not otherwise specified according to diagnostic and statistical manual of mental disorders,4th edition,nine constitutional thinner subjects and,thirtytwo obese patients were recruited from an outpatients clinic devoted to eating behavior disorders.Twentytwo healthy volunteers matched for age and gender were enrolled as healthy controls.All participants underwent a careful clinical examination.Demographic and anthropometric characteristics were obtained from a structured questionnaires.The presence of FD and,its subgroups,epigastric pain syndrome and postprandial distress syndrome(PDS) were diagnosed according to Rome Ⅲ criteria.The intensity-frequency score of broader dyspeptic symptoms such as early satiety,epigastric fullness,epigastric pain,epigastric burning,epigastric pressure,belching,nausea and vomiting were studied by a standardized questionnaire(0-6).Analysis of variance and post-hoc Sheffè tests were used for comparisons.RESULTS:90% of patients affected by anorexia nervosa,83.3% of patients affected by bulimia nervosa,90% of patients affected by ED not otherwise specified,55.6% of constitutionally thin subjects and 18.2% healthy volunteers met the Postprandial Distress Syndrome Criteria(χ 2,P < 0.001).Only one bulimic patient met the epigastric pain syndrome diagnosis.Postprandial fullness intensity-frequency score was significantly higher in anorexia nervosa,bulimia nervosa and ED not otherwise specified groups compared to the score calculated in the constitutional thinner group(4.15 ± 2.08 vs 1.44 ± 2.35,P = 0.003;5.00 ± 2.45vs 1.44 ± 2.35,P = 0.003;4.10 ± 2.23vs 1.44 ± 2.35,P = 0.002,respectively),the obese group(4.15 ± 2.08vs 0.00 ± 0.00,P < 0.001;5.00 ± 2.45vs 0.00 ± 0.00,P < 0.001;4.10 ± 2.23 vs 0.00 ± 0.00,P < 0.001,respectively) and healthy volunteers(4.15 ± 2.08 vs 0.36 ± 0.79,P < 0.001;5.00 ± 2.45 vs 0.36 ± 0.79,P < 0.001;4.10 ± 2.23 vs 0.36 ± 0.79,P < 0.001,respectively).Early satiety intensity-frequency score was prominent in anorectic patients compared to bulimic patients(3.85 ± 2.23 vs 1.17 ± 1.83,P = 0.015),obese patients(3.85 ± 2.23 vs 0.00 ± 0.00,P < 0.001) and healthy volunteers(3.85 ± 2.23 vs 0.05 ± 0.21,P < 0.001).Nausea and epigastric pressure were increased in bulimic and ED not otherwise specified patients.Specifically,nausea intensity-frequencyscore was significantly higher in bulimia nervosa and ED not otherwise specified patients compared to anorectic patients(3.17 ± 2.56 vs 0.89 ± 1.66,P = 0.04;2.70 ± 2.91 vs 0.89 ± 1.66,P = 0.05,respectively),constitutional thinner subjects(3.17 ± 2.56 vs 0.00 ± 0.00,P = 0.004;2.70 ± 2.91 vs 0.00 ± 0.00,P = 0.005,respectively),obese patients(3.17 ± 2.56 vs 0.00 ± 0.00,P < 0.001;3.17 ± 2.56 vs 0.00 ± 0.00,P < 0.001 respectively) and,healthy volunteers(3.17 ± 2.56 vs 0.17 ± 0.71,P = 0.002;3.17 ± 2.56 vs 0.17 ± 0.71,P = 0.001,respectively).Epigastric pressure intensityfrequency score was significantly higher in bulimic and ED not otherwise specified patients compared to constitutional thin subjects(4.67 ± 2.42 vs 1.22 ± 1.72,P = 0.03;4.20 ± 2.21 vs 1.22 ± 1.72,P = 0.03,respectively),obese patients(4.67 ± 2.42 vs 0.75 ± 1.32,P = 0.001;4.20 ± 2.21vs 0.75 ± 1.32,P < 0.001,respectively) and,healthy volunteers(4.67 ± 2.42 vs 0.67 ± 1.46,P = 0.001;4.20 ± 2.21vs 0.67 ± 1.46,P = 0.001,respectively).Vomiting was referred in 100% of bulimia nervosa patients,in 20% of ED not otherwise specified patients,in 15% of anorexia nervosa patients,in 22% of constitutional thinner subjects,and,in 5.6% healthy volunteers(χ 2,P < 0.001).CONCLUSION:PDS is common in eating disorders.Is it mandatory in outpatient gastroenterological clinics to investigate eating disorders in patients with PDS? | Antonella Santonicola Monica Siniscalchi Pietro Capone Serena Gallotta Carolina Ciacci Paola Iovino | 2012 | World Journal of Gastroenterology2012，18，32： | 5 |
| 3 | Clinical applications of squamous cell carcinoma antigenimmunoglobulins M to monitor chronic hepatitis C显示文摘Hepatitis C virus(HCV) is the main cause of chronic liver disease and cirrhosis in Western countries. Over time, the majority of cirrhotic patients develop hepatocellular carcinoma(HCC), one of the most common fatal cancers worldwide- fourth for incidence rate. A high public health priority need is the development of biomarkers to screen for liver disease progression and for early diagnosis of HCC development, particularly in the high risk population represented by HCV-positive patients with cirrhosis. Several studies have shown that serological determination of a novel biomarker, squamous cell carcinoma antigen-immunoglobulins M(SCCA-Ig M), might be useful to identify patients with progressive liver disease. In the initial part of this review we summarize the main clinical studies that have investigated this new circulating biomarker on HCV-infected patients, providing evidence that in chronic hepatitis C SCCA-Ig M may be used to monitor progression of liver disease, and also to assess the virological response to antiviral treatment. In the last part of this review we address other, not less important, clinical applications of this biomarker in hepatology. | Andrea Martini Andrea Gallotta Patrizia Pontisso Giorgio Fassina | 2015 | World Journal of Hepatology2015，7，29： | 3 |
| 4 | High risk of temporomandibular disorder in irritable bowel syndrome: Is there a correlation with greater illness severity?显示文摘AIM To investigate the prevalence and the risk of temporomandibular disorders(TMDs)in patients with irritable bowel syndrome(IBS)(including each subtype:constipation,diarrhoea,and mixed)compared to the general population.METHODS Between January 2014 and December 2015 we enrolled consecutively adult patients diagnosed with IBS at the outpatient clinic of the University of Salerno and healthy controls(HC)without IBS.At enrollment,we analyzed all patients for the presence of TMDs according to the Research Diagnostic Criteria for TMD.RESULTS We enrolled 91 IBS patients(23 IBS-D,30 IBS-C and38 IBS-M)and 57 HC in the study.We found a higher risk of having TMD(OR=3.41,95%CI:1.66-7.01)compared to the HC.The risk of having TMD was independent of IBS-subtype.Multiple regression analysis showed that facial pain was positively related to abdominal pain and higher level of depression.CONCLUSION IBS patients had a more than three times greater risk of TMD compared to HC.The risk of having TMDwas similar in different IBS subtypes.IBS patients that also fulfilled criteria for TMD seem to share along with chronic facial and abdominal pain a significant co-occurrence with psychiatric disorders and female preponderance.Key words:Temporomandibular disorders;Irritable bowel syndrome;Chronic pain;Facial pain;Abdominal pain;Irritable bowel syndrome severity score symptoms;Irritable bowel syndrome predominant diarrhea;Irritable bowel syndrome predominant constipation;Irritable bowel syndrome mixed?The Author(s)2017.Published by Baishideng Publishing Group Inc.All rights reserved. | Serena Gallotta Vincenzo Bruno Santo Catapano Nicola Mobilio Carolina Ciacci Paola Iovino | 2017 | World Journal of Gastroenterology2017，23，1： | 2 |
| 5 | Expression of cyclooxygenase-2 (COX-2), receptors for estrogen ( ER), and progesterone (PR) , p53, ki67, and neu pro- tein in endometrial cancer显示文摘 | Ferrandina G Ranelletti FO Gallotta V | 2005 | Gynecol Oncol2005，98，： | 1 |
| 6 | Natriuretic peptides(BNPand NT-proBNP):measurement and relevance in heart failure显示文摘 | Palazzuoli A Gallotta M Quatrini I | 2010 | VascHealth Risk Manag2010，6，： | 1 |
| 7 | A randomized study comparing the use of the Ligaclip with bipolar energy to prevent lymphocele during laparoscopic pelvic lymphadenectomy for gynecologic cancer显示文摘 | Gallotta V Fanfani F Rossitto C | 2010 | Am J Obstet Gynecol2010，203，5： | 1 |
| 8 | Natrluretic peptides(BNP and NT 'proBNP):measurement and relevance in heart failure 显示文摘 | Palazzuoli A Gallotta M Quatrini 1 | 2010 | Vasc neahh Risk Manag2010，6，3： | 1 |
| 9 | Pseudo-Meigs'syn- drome associated with malignant struma ovarii: a case re- port显示文摘 | Zannoni GF Gallotta V Legge F | 2004 | Gynecol Oncol2004，94，1： | 1 |
| 10 | Pseudo-Meigs'syndrome associated with malignant struma ovarii:a case report显示文摘 | Zannoni GF Gallotta V Legge F | 2004 | Gynecol Oncol2004，94，1： | 1 |
| 11 | Natriuretie peptides (BNP and NT-proBNP) : measurement and relevance in heart failure显示文摘 | Palazzuoli A Gallotta M Quatrini I | 2010 | Vase Health Risk Manag2010，6，6： | 1 |
| 12 | Osteoprotegerin and B-type natriuretic peptide in acute coronary syndromes with pre- served systolic function: relationto coronary artery disease extension 显示文摘 | PalazzuoliA Ascione R Gallotta M | 2009 | Int J Cardiol2009，137，3： | 1 |
| 13 | Natriuretic peptides (BNP and NT-proBNP) :measurement and relevance in heart fail- ure显示文摘 | Palazzuoli A Gallotta M Quatrini 1 | 2010 | Vasc Health Risk Manag2010，，6： | 1 |
| 14 | Natriuretic and NT-proBNP): measurement and relevance 显示文摘 | Palazzuoli A peptides (BNP in heart failure Gallotta M Quatrini I | 2010 | Vasc Health Risk Manag2010，6，： | 1 |
| 15 | Natriuret- ic peptides ( BNP and NT-proBNP) : measurement and relevance in heart failure 显示文摘 | Palazzuoli A Gallotta M Quatrini I | 2010 | Vase Health Risk Man- ag2010，6，3： | 1 |
| 16 | Natriuretic peptides (BNP and NT-proBNP) :measurement and relevance in heart fail- ure显示文摘 | I Palazzuoli A Gallotta M Quatrini I | 2010 | Vasc Health Risk Manag2010，6，2： | 1 |
| 17 | Natriuretic peptides(BNP and NT-pro BNP):measurement and relevance in heart failure显示文摘 | Palazzuoli A Gallotta M Quatrini I | 2010 | Vasc Health Risk Manag2010，6，3： | 1 |
| 18 | Progression of conservatively treated endometrial carcinoma after full term pregnancy:Acase report显示文摘 | Ferrandina G Zannoni GF Gallotta V | 2005 | Gynecol Oncol2005，99，1： | 1 |
| 19 | Natriuretic peptides(BNP and NT-proBNP): measurement and relevance in heart failure显示文摘 | Palazzuoli A Gallotta M Quatrini I | 2010 | Vasc Health Risk Manag2010，1，6： | 1 |
| 20 | Natriuretic peptides (BNP and NT-proBNP): measurement and relevance in heart failure 显示文摘 | Palazzuoli A Gallotta M Quatrini I | 2010 | VascHealthRiskManag2010，6，： | 1 |
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