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| 1 | Extraskeletal myxoid chondrosarcoma metastatic to the pancreas: A case report显示文摘Extraskeletal myxoid chondrosarcoma (EMC) is a lowgrade sarcoma characterized by developing metastases and local recurrence in high rate. It is mainly deep seated in the proximal extremities. The most common metastatic sites are the lungs, soft tissues, lymph nodes, bones and the brain. To our knowledge, no case of clearly defined EMC has been reported to date developing a metastasis in the pancreas. We describe a case of a man suffering from EMC who developed a single pancreatic metastasis 20 years after the initial diagnosis. A 49-year-old man was submitted to surgical excision of an EMC, in left thigh, 20 years ago. Fourteen years after the initial diagnosis a local recurrence in left thigh occurred. Multiple lesions of metastatic origin, in both lungs, were excised via thoracotomies until the time being. In 2003, as a part of a periodically performed imaging control, an abdominal CT scan was performed revealing a solid lesion in the pancreas. Distal pancreatectomy was performed. The histopathology of the excised specimen proved to be the one of metastatic lesion of EMC. The above-mentioned case of EMC is, as far as we know, the first one described developing a certain pancreatic metastasis. | C Fotiadis A Charalambopoulos S Chatzikokolis GC Zografos M Genetzakis R Tringidou | 2005 | World Journal of Gastroenterology2005，11，14： | 14 |
| 2 | Gardner's syndrome: A case report and review of the literature显示文摘Gardner's syndrome is an autosomal dominant disease characterized by the presence of colonic polyposis,osteomas and a multitude of soft tissue tumors. The syndrome may present at any age from 2 mo to 70 years with a variety of symptoms, either colonic or extracolonic.We present a case of a 11-year-old female patient with Gardner's syndrome who presented with a lumbar area desmoid tumor and treated with resection of the desmoid,restorative proctocolectomy and ileal pouch anal anastomosis,A review of the current literature has been performed. | C Fotiadis DK Tsekouras P Antonakis J Sfiniadakis M Genetzakis GC Zografos | 2005 | World Journal of Gastroenterology2005，11，34： | 10 |
| 3 | Colonic duplication in adults: Report of two cases presenting with rectal bleeding显示文摘Gastrointestinal duplication is an uncommon congenital abnormality in two-thirds of cases manifesting before the age of 2 years. Ileal duplication is common while colonic duplication, either cystic or tubular, is a rather unusual clinical entity that remains asymptomatic and undiagnosed in most cases. Mostly occurring in pediatric patients,colonic duplication is encountered in adults only in a few cases. This study reports two cases of colonic duplication in adults. Both cases presented with rectal bleeding on admission. The study was focused on clinical, imaging,histological, and therapeutical aspects of the presenting cases. Gastrografin enema established the diagnosis in both cases. The cystic structure and the adjacent part of the colon were excised en-block. The study implies that colonic duplication, though uncommon, should be included in the differential diagnosis of rectal bleeding. | C Fotiadis M Genetzakis I Papandreou EP Misiakos E Agapitos GC Zografos | 2005 | World Journal of Gastroenterology2005，11，32： | 7 |
| 4 | 维生素D对内皮功能的影响:一项随机、双盲、安慰剂对照试验显示文摘在非高血压人群中,低水平的25羟基维生素D[25-hydroxyvitamin D,25(OH)D]已证实与高血压风险增加有关,且维生素D缺乏与内皮功能障碍相关。然而,非高血压人群补充维生素D对内皮细胞功能的影响尚未得到验证。方法: | Borgi L McMullan C Wohlhueter A Curhan GC Fisher ND Forman JP 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 4 |
| 5 | 可卡因暴露通过miR-30C-5P/苹果酸酶1/活性氧通路升高血压和加强主动脉僵硬度显示文摘滥用可卡因可增加心血管病死亡和发病风险,然而,其中潜在的分子机制仍然未知。通过可卡因滥用小鼠模型,Zhu等发现重复注射可卡因可导致小鼠血压升高和主动脉僵硬度增加(主动脉中活性氧水平同时升高),这种现象类似于人类高血压中观察到的现象。 | 刘莉 叶鹏 Zhu W Wang H Wei J Sartor GC Bao MM Pierce CT Wahlestedt CR Dykxhoorn DM Dong C | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 6 | 星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。 | Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 | 2019 | 神经损伤与功能重建2019，14，6： | 2 |
| 7 | Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice显示文摘 | Schatteman GC Hanlon HD Jiao C | 2000 | J Clin Invest2000，106，4： | 1 |
| 8 | Blood derived angiogenesis accelerate blood-flow restoration in diabetic mice 显示文摘 | Schatteman GC Hanlon HD Jiao C | 2000 | J Clin Invest2000，106，4： | 1 |
| 9 | A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease显示文摘 | SESTI G MANNINO GC DE LORENZO C | 2013 | Atherosclerosis2013，231，1： | 1 |
| 10 | Haplotypes of IL-10 promoter vari- ants are associated with susceptibility to severe malarial anemia and func- tional changes in IL-10 production显示文摘 | Ouma C Davenport GC Were T | 2008 | Hum Genet2008，124，5： | 1 |
| 11 | Effects of prolongedautovehicle driving on male reproduction function a study among taxidrivers显示文摘 | Cini C Varricchio GC | 1996 | AmJ Ind Med1996，30，6： | 1 |
| 12 | Phase I investigation of recombinant anti-human vascular endothelial growth factor antibody in patients with advanced cancer显示文摘 | Jayson GC Mulatero C Ranson M | 2005 | Eur J Cancer2005，41，4： | 1 |
| 13 | Alteration in urinary matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio predicts recurrence in nonmuscle-invasive bladder cancer 显示文摘 | Durkan GC Nutt JE Marsh C | 2003 | Clin Cancer Res2003，9，7： | 1 |
| 14 | Increased hepatocyte CYPⅡE1 expression in a rat nutritional model of hepatic steatosis with inflammation 显示文摘 | WELTMAN MD FARRELL GC LIDDLE C | 1996 | Gastroenterology1996，111，6： | 1 |
| 15 | Safety of repair for severe duodenal injuries显示文摘 | Velmahos GC Constantinou C Kasotakis G | 2008 | World J Surg2008，32，1： | 1 |
| 16 | State of the art in thora- cospic surgery: a personal experience of 2000 videothoracoscopic procedures and an overview of the literature 显示文摘 | Roviaro GC Varoli F Vergani C | 2002 | Surg Endosc2002，16，6： | 1 |
| 17 | Vascular integrins in tumor angiogenesis:Mediators and therapeutic targets显示文摘 | Alghisi GC Rüegg C | 2006 | Endothelium2006，13，2： | 1 |
| 18 | Skin closure after total hip replacement:a randomised controlled trial of skin adhesive versus surgical staples显示文摘 | Livesey C Wylde V Descamps S Estela CM Bannister GC Learmonth ID | | 0，，06： | 1 |
| 19 | Biology of bone marrow- derived endothelial cell precursors 显示文摘 | Sehatteman GC Dunnwahl M Jiao C | 2007 | Am J Physiol Heart Circ Physiol2007，292，1： | 1 |
| 20 | Effect of pravastatin on cardiovascular events in people with chronic kidney disease显示文摘 | Tonelli M Isles C Curhan GC | | 0，，： | 1 |
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