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| 1 | Clinical epidemiology and disease burden of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is defined as the presence of hepatic fat accumulation after the exclusion of other causes of hepatic steatosis, including other causes of liver disease, excessive alcohol consumption, and other conditions that may lead to hepatic steatosis. NAFLD encompasses a broad clinical spectrum ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis(NASH), advanced fibrosis, cirrhosis, and finally hepatocellular carcinoma(HCC). NAFLD is the most common liver disease in the world and NASH may soon become the most common indication for liver transplantation. Ongoing persistence of obesity with increasing rate of diabetes will increase the prevalence of NAFLD, and as this population ages, many will develop cirrhosis and end-stage liver disease. There has been a general increase in the prevalence of NAFLD, with Asia leading the rise, yet the United States is following closely behind with a rising prevalence from 15% in 2005 to 25% within 5 years. NAFLD is commonly associated with metabolic comorbidities, including obesity, type Ⅱ diabetes, dyslipidemia, and metabolic syndrome. Our understanding of the pathophysiology of NAFLD is constantly evolving. Based on NAFLD subtypes, it has the potential to progress into advanced fibrosis, end-stage liver disease and HCC. The increasing prevalence of NAFLD with advanced fibrosis, is concerning because patients appear toexperience higher liver-related and non-liver-related mortality than the general population. The increased morbidity and mortality, healthcare costs and declining health related quality of life associated with NAFLD makes it a formidable disease, and one that requires more in-depth analysis. | Brandon J Perumpail Muhammad Ali Khan Eric R Yoo George Cholankeril Donghee Kim Aijaz Ahmed | 2017 | World Journal of Gastroenterology2017，23，47： | 70 |
| 2 | Household air pollution and lung cancer in China:a review of studies in Xuanwei显示文摘Over half of the world's population is exposed to household air pollution from the burning of solid fuels at home. Household air pollution from solid fuel use is a leading risk factor for global disease and remains a major public health problem, especially in low- and mid-income countries. This is a particularly serious problem in China, where many people in rural areas still use coal for household heating and cooking. This review focuses on several decades of research carried out in Xuanwei County, Yunnan Province, where household coal use is a major source of household air pollution and where studies have linked household air pollution exposure to high rates of lung cancer. We conducted a series of case-control and cohort studies in Xuanwei to characterize the lung cancer risk in this population and the factors associated with it. We found lung cancer risk to vary substantially between different coal types, with a higher risk associated with smoky(i.e., bituminous) coal use compared to smokeless(i.e., anthracite) coal use. The installation of a chimney in homes resulted in a substantial reduction in lung cancer incidence and mortality. Overall, our research underscores the need among existing coal users to improve ventilation, use the least toxic fuel, and eventually move toward the use of cleaner fuels, such as gas and electricity. | Wei Jie Seow Wei Hu Roel Vermeulen H.Dean Hosgood III George S.Downward Robert S.Chapman Xingzhou He Bryan A.Bassig Christopher Kim Cuiju Wen Nathaniel Rothman Qing Lan | 2014 | Chinese Journal of Cancer2014，33，10： | 15 |
| 3 | Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics显示文摘Polymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules and cells.Among others,methacrylated gelatin(GelMA)has become a representative hydrogel formulation,finding various biomedical applications.Recent efforts on GelMA-based hydrogels have been devoted to combining them with bioactive and functional nanomaterials,aiming to provide enhanced physicochemical and biological properties to GelMA.The benefits of this approach are multiple:i)reinforcing mechanical properties,ii)modulating viscoelastic property to allow 3D printability of bio-inks,iii)rendering electrical/magnetic property to produce electro-/magneto-active hydrogels for the repair of specific tissues(e.g.,muscle,nerve),iv)providing stimuli-responsiveness to actively deliver therapeutic molecules,and v)endowing therapeutic capacity in tissue repair process(e.g.,antioxidant effects).The nanomaterial-combined GelMA systems have shown significantly enhanced and extraordinary behaviors in various tissues(bone,skin,cardiac,and nerve)that are rarely observable with GelMA.Here we systematically review these recent efforts in nanomaterials-combined GelMA hydrogels that are considered as next-generation multifunctional platforms for tissue therapeutics.The approaches used in GelMA can also apply to other existing polymeric hydrogel systems. | Amal George Kurian Rajendra KSingh Kapil DPatel Jung-Hwan Lee Hae-Won Kim | 2022 | Bioactive Materials2022，7，2： | 11 |
| 4 | Factors influencing syphilis treatment failure and/or re-infection in HIV co-infected patients: immunosuppression or behaviors显示文摘背景最近的研究报导了有高度的梅毒的总的来说增加的率人的免疫不全评估病毒(HIV ) 合作感染。然而,几乎在 HIV 影响梅毒治疗失败或再感染的因素没有很少信息共同感染的病人。我们进行了研究评估在 HIV 与梅毒治疗 failure/re-infection 联系的因素到 2007 年 12 月的从 2005 年 1 月的感染 HIV 的病人的 3542 个医药记录列在后面在上面的我们考察了的共同感染的 patients.Methods 在在纽约的 HIV 诊所城市。病人们被快速的血浆分类重获 titer ( RPR )进 success/serofast (在到在治疗以后的 12 个月的 RPR 的4褶层减少, RPR 变换到没有4褶层增加的非电抗的、固执地稳定的反应 RPR ),并且 failure/re-infection (失败到在到在治疗以后的 12 个月的 RPR 的减少 4 褶层,从基线的 RPR 的4褶层增加)在满足了资格标准的 156 个病人的一个总数之中的 .Results ,( 78.2 ) 122 在 success/serofast 范畴下面,并且( 21.8 ) 34 在 failure/r 下面高度活跃的 antiretroviral 治疗(HAART ) 的 HIV 病毒的负担, CD4 房间计数,和使用没与梅毒治疗 failure/re-infection 被联系。然而,早梅毒舞台(OR:11.036, 95 CI:2.499-48.740, P=0.002 ) 并且高度(164 ) RPR titers (或:715.921, 95 CI:422.175-23 113.396, P 0.001 ) 显著地 associated.Conclusions 没有关联与梅毒治疗失败或再感染与沮丧的有免疫力的州被看见。然而,有早阶段梅毒的协会建议危险心理性行为可以是最重要的带因素,强调对安全的性教育的需要。 | Jong Hun Kim George Psevdos Jr Jin Suh Victoria Sharp | 2011 | Chinese Medical Journal2011，，14： | 10 |
| 5 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 6 | Update on Sphincter of Oddi Dysfunction: A Review显示文摘Sphincter of Oddi dysfunction(SOD)encompasses a spectrum of clinical syndromes that are not fully understood,and various diagnostic and therapeutic methods have had varying results depending on the type of dysfunction.This review explored various mechanisms that might play a role in SOD and methods of diagnosis and management.It is important to rule out other causes of abdominal pain with laboratory testing,imaging studies,and endoscopic procedures.Medications that affect sphincter motility should be identified as well.Manometry is the gold standard for diagnosis but it is not always required.For example,patients with type I SOD may have symptomatic improvement with sphincterotomy without need for a diagnostic manometry.Hepatobiliary scintigraphy and fatty meal sonography may also have diagnostic utility.Sphincterotomy is not always effective for symptomatic improvement in type II and III SOD.Alternate therapies with calcium channel blockers and botulinum toxin have been studied and might be considered as options after discussing the risks and benefits with the patients. | Jaimy Villavicencio Kim George Y.Wu | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 4 |
| 7 | Enhanced biological phosphorus removal using thermal alkaline hydrolyzed municipal wastewater biosolids显示文摘This study reports the feasibility of using municipal wastewater biosolids as an alternative carbon source for biological phosphorus removal.The biosolids were treated by a lowtemperature,thermal alkaline hydrolysis process patented by Lystek International Inc.(Cambridge,ON,Canada)to produce short-chain volatile fatty acids and other readily biodegradable organics.Two sequencing batch reactors(SBRs)were operated with synthetic volatile fatty acids(Syn VFA)and readily biodegradable organics produced from the alkaline hydrolysis of municipal wastewater biosolids(Lystek)as the carbon source,respectively.Municipal wastewaters with different strengths and COD:N:P ratios were tested in the study.The reactors’performances were compared with respect to nitrogen and phosphorus removal.It was observed that phosphorus removal efficiencies were between 98%–99%and 90%–97%and nitrogen removal efficiencies were 78%–81%,and 67%for the Syn VFA and Lystek,respectively.However,the kinetics for phosphorus release and uptake during the anaerobic and aerobic stages with Lystek were observed to be significantly lower than Syn VFA due to the presence of higher order VFAs(C4 and above)and other fermentable organics in the Lystek. | Masuduz Zaman Mingu Kim George Nakhla Ajay Singh Fenghua Yang | 2019 | Journal of Environmental Sciences2019，31，12： | 4 |
| 8 | Worldwide Survey on the Methods, Efficacy, and Safety of Catheter Ablation for Human Atrial Fibrillation显示文摘 | Riccardo Cappato Hugh Calkins Shih-Ann Chen Wyn Davies Yoshito Iesaka Jonathan Kalman You-Ho Kim George Klein Douglas Packer Allan Skanes | 2005 | Circulation2005，，9： | 3 |
| 9 | QT prolongation is associated with increased mortality in end stage liver disease显示文摘AIM To determine the prevalence of QT prolongation in a large series of end stage liver disease(ESLD) patients and its association to clinical variables and mortality.METHODS The QT interval was measured and corrected for heart rate for each patient,with a prolonged QT cutoff defined as QT > 450 ms for males and QT > 470 ms for females.Multiple clinical variables were evaluated including sex,age,serum sodium,international normalized ratio,creatinine,total bilirubin,beta-blocker use,Model for EndStage Liver Disease(MELD),MELD-Na,and etiology of liver disease. RESULTS Among 406 ESLD patients analyzed,207(51.0%) had QT prolongation. The only clinical variable associated with QT prolongation was male gender(OR = 3.04,95%CI:2.01-4.60,P < 0.001). During the study period,187patients(46.1%) died. QT prolongation was a significant independent predictor of mortality(OR = 1.69,95%CI:1.03-2.77,P = 0.039). In addition,mortality was also associated with viral etiology of ESLD,elevated MELD score and its components(P < 0.05 for all). No significant reversibility in the QT interval was seen after liver transplantation. CONCLUSION QT prolongation was commonly encountered in an ESLD population,especially in males,and served as a strong independent marker for increased mortality in ESLD patients. | Sun Moon Kim Bennet George Diego Alcivar-Franco Charles L Campbell Richard Charnigo Brian Delisle Jonathan Hundley Yousef Darrat Gustavo Morales Samy-Claude Elayi Alison L Bailey | 2017 | World Journal of Cardiology2017，9，4： | 3 |
| 10 | Microcellular extrusion foaming of poly(lactide)/poly(butylene adipate-co-terephthalate) blends显示文摘 | Srikanth Pilla Seong G. Kim George K. Auer Shaoqin Gong Chul B. Park | 2009 | Materials Science & Engineering C2009，，2： | 2 |
| 11 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 12 | CREMa overexpression decreases IL-2 production,induces a TH17 phenotype and accelerates autoimmunity显示文摘Dear Editor,External cytokines produced by cells of the innate immune system induce the dif-ferentiation of CD4+T cells into helper T cell subsets with distinct functions and cytokine profiles.Apart from TH1 and TH2 cells a third subset of helper T cells has been described,which is characterized by increased expression of IL-17A,IL-17F,IL-21 and IL-22(TH17 cells). | Ralph Lippe Kim Ohl Georg Varga Thomas Rauen Jose C.Crispin Yuang-Taung Juang Stefanie Kuerten Frank Tacke Marc Wolf Kirsten Roebrock Thomas Vogl Eva Verjans Nora Honke Jan Ehrchen Dirk Foell Boris Skryabin Norbert Wagner George C.Tsokos Johannes Roth Klaus Tenbrock | 2012 | Journal of Molecular Cell Biology2012，4，2： | 2 |
| 13 | Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing显示文摘 | Tae-Hoon Kim Sung-Hee Kim George K. Sádor Yong-Deok Kim | 2014 | Archives of Oral Biology2014，，： | 2 |
| 14 | Updated Worldwide Survey on the Methods, Efficacy, and Safety of Catheter Ablation for Human Atrial Fibrillation显示文摘 | Riccardo Cappato Hugh Calkins Shih-Ann Chen Wyn Davies Yoshito Iesaka Jonathan Kalman You-Ho Kim George Klein Andrea Natale Douglas Packer Allan Skanes Federico Ambrogi Elia Biganzoli | 2010 | Circulation: Arrhythmia and Electrophysiology2010，，1： | 2 |
| 15 | Comparative Effectiveness for Survival and Renal Function of Partial and Radical Nephrectomy for Localized Renal Tumors: A Systematic Review and Meta-Analysis显示文摘 | Simon P. Kim R. Houston Thompson Stephen A. Boorjian Christopher J. Weight Leona C. Han M. Hassan Murad Nathan D. Shippee Patricia J. Erwin Brian A. Costello George K. Chow Bradley C. Leibovich | 2012 | The Journal of Urology2012，，： | 2 |
| 16 | Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion显示文摘Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone erosion.Macrophage colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,the role of M-CSF in arthritic bone erosion is not completely understood.Here,we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS,a receptor for M-CSF,leading to the generation of FMS intracellular domain(FICD)fragments.Increased levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory responses.Moreover,myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis model.The FICD formed a complex with DAP5,and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATcl protein expression.Moreover,targeting the MNK1/2 pathway diminished arthritic bone erosion.These results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion. | Se Hwan Mun Seyeon Bae Steven Zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim George Kalliolias Chitra Lekha Dahia Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun Park-Min | 2021 | Bone Research2021，9，4： | 2 |
| 17 | Antibiotic resistance in Escherichia coli outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA)显示文摘 | George G. Zhanel Tamiko L. Hisanaga Nancy M. Laing Melanie R. DeCorby Kim A. Nichol Barb Weshnoweski Jack Johnson Ayman Noreddin Don E. Low James A. Karlowsky Daryl J. Hoban | 2006 | International Journal of Antimicrobial Agents2006，，6： | 2 |
| 18 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 19 | Acute and chronic toxicity of nickel to nitrifiers at different temperatures显示文摘This study investigated the acute nickel toxicity on nitrification of low ammonia synthetic wastewater at 10, 23, and 35°C. The nickel inhibition half-velocity constants(K_(I,Ni)) for ammonia oxidizing bacteria(AOB) and nitrite oxidizing bacteria(NOB) based on Ni/MLSS ratio at 10, 23, and 35°C were 5.4 and 5.6 mg Ni/g MLSS, 4.6 and 3.5 mg Ni/g MLSS, and 9.1 and 2.7 mg Ni/g MLSS, respectively. In addition, chronic toxicity of nickel to nitrification of low ammonia synthetic wastewater was investigated at 10°C in two sequencing batch reactors(SBRs). Long-term SBRs operation and short-term batch tests were comparable with respect to the extent of inhibition and corresponding Ni/MLSS ratio. The μ_(max), b, and K_o of AOB were 0.16 day^(-1), 0.098 day^(-1) and 2.08 mg O_2/L after long-term acclimatization to nickel of 1 mg/L at 10°C, high dissolved oxygen(DO)(7 mg/L) and long solids retention time(SRT) of 63–70 days. Acute nickel toxicity of nitrifying bacteria was completely reversible. | Xiaoguang Liu Mohammad M.I.Chowdhury Masuduz Zaman Mingu Kim George Nakhla | 2019 | Journal of Environmental Sciences2019，31，8： | 2 |
| 20 | An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma显示文摘 | George P. Kim Michelle R. Mahoney Daniel Szydlo Tony S. K. Mok Robert Marshke Kyle Holen Joel Picus Michael Boyer Henry C. Pitot Joseph Rubin Philip A. Philip Anna Nowak John J. Wright Charles Erlichman | 2012 | Investigational New Drugs2012，，1： | 2 |
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