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| 1 | Importance of fatigue and its measurement in chronic liver disease显示文摘The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: physical performance measures, cognitive performance measures, mood/behavioral measures, brain imaging and serological measures. Treatment with non-pharmacological agents have been shown to be effective in symptom reduction, whereas pharmacological agents have not been shown effective. | Lynn H Gerber Ali A Weinstein Rohini Mehta Zobair M Younossi | 2019 | World Journal of Gastroenterology2019，25，28： | 7 |
| 2 | On the time value of ruin 显示文摘 | Shiu E S W | 1998 | North American Actuarial Journal1998，2，1： | 1 |
| 3 | On convex principles of premium calculation显示文摘 | Deprez O Gerber H U | 1985 | Insurance: Mathematics and Economics1985，，4： | 1 |
| 4 | On the time value of ruin显示文摘 | Gerber H U Shiu E S W | 1998 | North American Actuarial Journal1998，2，1： | 1 |
| 5 | VEGF regulateshaematopoietic stem cell survival by an internal autocrine loopmechanism显示文摘 | Gerber H P Malik A K Solar G P | 2002 | Nature2002，417，6892： | 1 |
| 6 | Optimal dividends in an Ornstein-Uhlenbeck type model with credit and debit interest显示文摘 | Cai J Gerber H U Yang H | | 0，，02： | 1 |
| 7 | Implications of a New Definition of Vitamin D Deficiency in a Multiracial US Adolescent Population: The National Health and Nutrition Examination Survey III 显示文摘 | Saintonge S Bang H Gerber LM | 2009 | Pediatriea2009，123，3： | 1 |
| 8 | Yascular endothe- lial growth factor induces expression of the antiapoptotic proteins Bcl-2 and Al in vascular endothelial cells显示文摘 | GERBER H P DIXIT Y FERRARA N | 1998 | J Biol Chem1998，273，13： | 1 |
| 9 | Atomic force microscope 显示文摘 | Binnig G Quate C F Gerber C H | 1986 | Physical Review1986，56，9： | 1 |
| 10 | Mathematical fun with the compound binomial process显示文摘 | Gerber H U | 1988 | ASTIN Bulletin1988，18，： | 1 |
| 11 | Genetic applications of an inverse polymerase chain reaction 显示文摘 | Ochman H Gerber A S Hartl D L | 1988 | Genetics1988，120，： | 1 |
| 12 | Association between serum apoli- poprotein C( Ⅱ ) concentration and coronary heart disease 显示文摘 | Gerber Y Goldbourt U Cohen H | 2002 | PrevMed2002，35，1： | 1 |
| 13 | An extension of the renewal equation and its application in the collective theory of risk显示文摘 | Gerber H U | 1970 | Scandinavian Actuarial Journal1970，3，： | 1 |
| 14 | On optimal dividend strategy in the compound Poisson model 显示文摘 | GERBER H U SHIU E S W | 2006 | North Americal Actuarial2006，10，2： | 1 |
| 15 | Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti- VEGF antibodies 显示文摘 | Gerber H P Wu X Yu L eL al | 2007 | Proc Nad Acad Sci USA2007，104，9： | 1 |
| 16 | Mathematical fun with ruin theory显示文摘 | Gerber H U | 1988 | Mathematics and Economics1988，7，： | 1 |
| 17 | Risk theory for the compound Poisson process that is perturbed by diffusion显示文摘 | Dufresne F Gerber H U | 1991 | Insurance Math Econom1991，10，： | 1 |
| 18 | On the time value of ruin 显示文摘 | Gerber H U Shiu E S W | 1998 | North American Actuarial Journal1998，2，1： | 1 |
| 19 | Capillary regression in vascular endothelial growth factor-deficient skeletal muscle显示文摘 | Tang K Breen E C Gerber H P | | 0，，01： | 1 |
| 20 | Atomic forcemicroscope 显示文摘 | Binng G Quate C F Gerber C H | 1986 | Physical Review Letters1986，56，9： | 1 |
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