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| 1 | Histone modifications and alcohol-induced liver disease:Are altered nutrients the missing link?显示文摘Alcoholism is a major health problem in the United States and worldwide,and alcohol remains the single most significant cause of liver-related diseases and deaths.Alcohol is known to influence nutritional status at many levels including nutrient intake,absorption,utilization,and excretion,and can lead to many nutritional disturbances and deficiencies.Nutrients can dramatically affect gene expression and alcohol-induced nutrient imbalance may be a major contributor to pathogenic gene expression in alcohol-induced liver disease(ALD).There is growing interest regarding epigenetic changes,including histone modifications that regulate gene expression during disease pathogenesis.Notably,modifications of core histones in the nucleosome regulate chromatin structure and DNA methylation,and control gene transcription.This review highlights the role of nutrient disturbances brought about during alcohol metabolism and their impact on epigenetic histone modifications that may contribute to ALD.The review is focused on four critical metabolites,namely,acetate,S-adenosylmethionine,nicotinamide adenine dinucleotide and zinc that are particularly relevant to alcohol metabolism and ALD. | Akshata Moghe Swati Joshi-Barve Smita Ghare Leila Gobejishvili Irina Kirpich Craig J McClain Shirish Barve | 2011 | World Journal of Gastroenterology2011，17，20： | 6 |
| 2 | A model for exponentially decaying inventories显示文摘 | Ghare P N Schrader G F | 1963 | Journal of Industrial Engineering1963，，15： | 1 |
| 3 | A model for exponentially decaying inventories显示文摘 | GHARE P M SCHRADER S F | 1963 | Journal of Industrial Engineering1963，14，5： | 1 |
| 4 | A model for exponentially decaying inventories显示文摘 | Ghare P M Schrader GF | 1963 | Journal of Industrial Engineering1963，，14： | 1 |
| 5 | A model for exponentially decaying inventories显示文摘 | Ghare P Schrader G | 1963 | Journal of Industrial Engineering1963，14，： | 1 |
| 6 | A Model for Exponential Decaying Inventory显示文摘 | Ghare P M Sch rader G F | 1963 | Journal of Engineering1963，14，： | 1 |
| 7 | A model for exponentially decaying inventory显示文摘 | Ghare P Schrader G | 1963 | Journal of Industrial Engineering1963，14，5： | 1 |
| 8 | A model for exponentially decaying inventories显示文摘 | Ghare P N Schrader G F | 1963 | Journal of Industrial Engineering1963，14，6： | 1 |
| 9 | A model for exponentially decaying inventory显示文摘 | Ghare P M S chrader G P | 1963 | Journal of Industrial Engineering1963，14，6： | 1 |
| 10 | A model for exponentially de- caying inventory 显示文摘 | GHARE P M SCHRADER S F | 1963 | Journal of Industrial Engineering1963，14，： | 1 |
| 11 | A model for exponentially decaying inventory显示文摘 | Ghare P M Schrader G F | 1963 | Journal of Industrial Engineering1963，14，6： | 1 |
| 12 | A model for an exponentially decaying inventory显示文摘 | Ghare P M | 1963 | Journal of Industrial Engi- neering1963，14，5： | 1 |
| 13 | A model for exponentially decaying inventory 显示文摘 | Ghare P M Schrader G F | 1963 | Journal of Industrial Engineering1963，14，5： | 1 |
| 14 | Ethanol inhibits lipid raft-mediated TCR signaling and IL-2expression:potential mech-anism of alcohol-induced immune suppression显示文摘 | Ghare S Patil M Hote P | 2011 | Alcohol Clin Exp Res2011，35，： | 1 |
| 15 | Ethanol inhibites lipid raft-mediatedTCR signaling and IL-2 expression:potential mechanism of alcohol-in-duced immune suppression显示文摘 | Ghare S Patil M Hote P | 2011 | Alcohol Clin Exp Res2011，35，8： | 1 |
| 16 | A model for an exponentially decaying inventory显示文摘 | Ghare P M Schrader G P | 1963 | Journal of Industrial Engineering1963，14，5： | 1 |
| 17 | A model for an exponentially decaying inventory 显示文摘 | Ghare P M Schrader G F | 1963 | Journal of IndustrialEngineering1963，14，6： | 1 |
| 18 | A model for exponentially decaying inventory显示文摘 | Ghare P M Schrader G | 1963 | Industrial Engineering1963，14，5： | 1 |
| 19 | A model for exponentially decaying inventory显示文摘 | Ghare P M Scharder G P | 1963 | Ind Eng1963，4，： | 1 |
| 20 | A Model for Exponential Decaying Inventory显示文摘 | Ghare P M Sch rader G F | 1963 | Journal of Engineering1963，14，： | 1 |
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